公开(公告)号：US20200163928A1

公开(公告)日：2020-05-28

申请号：US16776919

申请日：2020-01-30

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/51 ,  A61K9/16 ,  B05B13/02 ,  A61K9/10 ,  A61K9/00 ,  A61J3/02 ,  B01J3/00 ,  B05B1/34 ,  B01D46/24 ,  B01J4/00 ,  B01J19/10 ,  B01J2/04 ,  A61K9/14 ,  B01J19/26 ,  B01J3/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20180221849A1

公开(公告)日：2018-08-09

申请号：US15894513

申请日：2018-02-12

Applicant: CRITITECH, INC.

Inventor： Greg S. JOHNSON ,  Bala SUBRAMANIAM ,  Fenghui NIU ,  Jahna C. ESPINOSA ,  Charles J. DECEDUE ,  Gary E. CLAPP ,  Jacob M. SITTENAUER

IPC: B01J19/24 ,  B01D9/00 ,  A61K9/16 ,  B01D29/66 ,  B01J3/00 ,  B01J4/00 ,  B01J8/00

CPC classification number: B01J19/24 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0054 ,  B01D29/661 ,  B01J3/008 ,  B01J4/002 ,  B01J8/006 ,  B01J2219/00051 ,  B01J2219/00162 ,  B01J2219/00164 ,  Y02P20/544

Abstract: An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.

公开(公告)号：US20210393569A1

公开(公告)日：2021-12-23

申请号：US17467655

申请日：2021-09-07

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61K9/51 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20210000786A1

公开(公告)日：2021-01-07

申请号：US17023635

申请日：2020-09-17

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61K9/51 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.