公开(公告)号：US11583499B2

公开(公告)日：2023-02-21

申请号：US17333629

申请日：2021-05-28

Applicant: CRITITECH, INC.

Inventor： Gere S. Dizerega ,  Michael Baltezor ,  Sam Campbell ,  Charles J. Decedue ,  Matthew McClorey

IPC: A61K9/16 ,  A61K31/337 ,  C07K16/28 ,  A61K9/00 ,  A61K39/00

Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, and intracystic injection.

公开(公告)号：US11523983B2

公开(公告)日：2022-12-13

申请号：US17315804

申请日：2021-05-10

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/10 ,  A61K9/00 ,  A61P35/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/16

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US11104663B2

公开(公告)日：2021-08-31

申请号：US16650670

申请日：2018-09-28

Applicant: CRITITECH, INC.

Inventor： Mark Williams ,  Jacob Sittenauer ,  Shelby Clark ,  Joseph Farthing ,  Michael Baltezor ,  Matthew McClorey

IPC: C07D401/10 ,  A61K9/14 ,  A61K9/00 ,  A61P31/04

Abstract: The present disclosure relates to ciprofloxacin polymorphs and their use in treating infections.

公开(公告)号：US20210259959A1

公开(公告)日：2021-08-26

申请号：US17315804

申请日：2021-05-10

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/00 ,  A61P35/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/10

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US10507195B2

公开(公告)日：2019-12-17

申请号：US15895197

申请日：2018-02-13

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary Clapp

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61J3/02 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US09814685B2

公开(公告)日：2017-11-14

申请号：US15174505

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC: A61K9/51 ,  A61K9/16 ,  A61K31/337 ,  B01J2/04 ,  B01J19/26 ,  B01J19/10 ,  B01J4/00 ,  A61K9/14 ,  A61K9/10 ,  A61K9/00 ,  B01J3/00

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20240156861A1

公开(公告)日：2024-05-16

申请号：US18492232

申请日：2023-10-23

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Holly Maulhardt ,  Maria Montes-Gonzalez ,  Jahna Espinosa ,  Mark Williams ,  Joseph Farthing ,  Jacob Sittenauer

IPC: A61K33/243 ,  A61K9/10 ,  A61K47/10 ,  A61P35/00

CPC classification number: A61K33/243 ,  A61K9/10 ,  A61K47/10 ,  A61P35/00

Abstract: Suspensions and their use for treating tumors are provided, where the suspensions include (a) particles of at least 95% by weight of cisplatin, wherein the particles have a specific surface area (SSA) of at least 3.5 m2/g, (b) about 40% to about 60% w/w of glycerin, (c) about 20% to about 40% w/w of propylene glycol, (d) about 5% to about 20% w/w of ethanol, and (e) about 5% to about 10% w/w of 0.9% sodium chloride in water.

公开(公告)号：US10507181B2

公开(公告)日：2019-12-17

申请号：US16444299

申请日：2019-06-18

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61K31/337 ,  A61K9/10 ,  A61P35/00 ,  A61K9/16 ,  A61K47/02 ,  A61K9/14 ,  A61K47/26 ,  A61P11/00

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US20180360748A1

公开(公告)日：2018-12-20

申请号：US16007095

申请日：2018-06-13

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61P11/00 ,  A61P35/00 ,  A61K31/337 ,  A61K9/10 ,  A61K9/16

CPC classification number: A61K9/0078 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1623 ,  A61K31/337 ,  A61K47/02 ,  A61K47/26 ,  A61P11/00 ,  A61P35/00

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US20180353630A1

公开(公告)日：2018-12-13

申请号：US16064258

申请日：2016-12-23

Applicant: CritiTech, Inc.

Inventor： Joseph Farthing ,  Michael Baltezor

IPC: A61L2/00

CPC classification number: A61L2/0088 ,  A61L2/0011 ,  A61L2/0082 ,  A61L2/025 ,  A61L2/16 ,  A61L2202/15 ,  A61L2202/21 ,  A61N7/00

Abstract: Disclosed here are methods for tissue sterilization involving producing sonic energy from one or more sonic energy sources located at least partially within a pressurized chamber; and contacting a biological tissue positioned in the pressurized chamber with a supercritical fluid for a first time period effective to sterilize the biological tissue, where the contacting occurs exclusively at a temperature and pressure at or above the critical point of the supercritical fluid.