公开(公告)号：US20240395528A1

公开(公告)日：2024-11-28

申请号：US18693363

申请日：2022-09-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Robert HAUFLER ,  William LOYD

IPC: H01J49/06 ,  H01J49/02

Abstract: In one aspect, a mass spectrometer is disclosed, which includes an ion path along which an ion beam can propagate, and an ion beam deflector positioned in the ion path and configured to modulate transfer of an ion beam received from an upstream section of the ion path to a downstream section thereof, said ion beam deflector comprising at least one electrically conductive electrode positioned relative to one another to provide an opening through which the ion beam can pass, where the two electrodes are electrically insulated relative to one another so as to allow maintaining each electrode at a DC potential independent of a DC potential at which the other electrode is maintained.

公开(公告)号：US20210366701A1

公开(公告)日：2021-11-25

申请号：US16980956

申请日：2019-04-10

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Nic BLOOMFIELD ,  Igor CHERNUSHEVICH ,  Robert HAUFLER

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m/z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m/z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.

公开(公告)号：US20240274428A1

公开(公告)日：2024-08-15

申请号：US18560556

申请日：2022-05-12

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Aaron Timothy BOOY ,  Robert HAUFLER

IPC: H01J49/06 ,  H01J49/40

CPC classification number: H01J49/068 ,  H01J49/40

Abstract: An ion mirror for use in a time-of-flight mass spectrometer includes a mirror ring sub-assembly for creating an electric potential field to decelerate incoming ions and accelerate outgoing ions, and a grid sub-assembly comprising one or more grid plates, which define bounds of the electrical potential field of the ion mirror. The mirror ring sub-assembly and the grid sub-assembly are coaxially superposed, and the mirror ring sub-assembly is mechanically engaged with the grid sub-assembly only at one of the grid plates.

公开(公告)号：US20250132141A1

公开(公告)日：2025-04-24

申请号：US18685537

申请日：2022-08-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Takashi BABA ,  Manuel FAUR ,  Tiberiu GERA ,  Robert HAUFLER ,  William LOYD ,  Pavel RYUMIN ,  Congsheng YOU

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

Abstract: A system for applying RF voltages to a multipole ion processing device, configured for use in a mass spectrometer, includes a first RF generator configured to generate a first RF voltage and apply to a first pole electrode set, a second RF generator configured to generate a second RF voltage and apply to a second pole electrode set, a first amplitude adjustor configured to adjust an amplitude of the first RF voltage, a second amplitude adjustor configure to adjust an amplitude of the second RF voltage, and a phase adjustor in communication with the first RF generator and the second RF generator to adjust phase output of at least one of the first RF generator and the second RF generator so as to adjust a phase differential between the first RF voltage and the second RF voltage to be within a desired range.