公开(公告)号：US09943256B2

公开(公告)日：2018-04-17

申请号：US14260948

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20180100810A1

公开(公告)日：2018-04-12

申请号：US15289516

申请日：2016-10-10

Applicant: Altria Client Services LLC

Inventor： Amrita Sahu ,  Henry M. Dante ,  Jerry W. Morris

IPC: G01N21/94 ,  G01N21/3563

CPC classification number: G01N21/94 ,  B07C5/3422 ,  B07C5/3427 ,  B07C2501/0081 ,  B07C2501/009 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/85 ,  G01N2021/845 ,  G01N2021/8455 ,  G01N2021/8466 ,  G01N2021/8592 ,  G01N2201/10 ,  G01N2201/127

Abstract: Methods and systems for detecting foreign material within a product stream in real-time, involve illuminating a portion of the agricultural product stream with light spanning a wavelength range including or within near-infrared and/or shortwave infrared wavelengths; scanning a line of the illuminated agricultural product stream to acquire a hyperspectral image of the line, the hyperspectral image of the line having a width of a single pixel; processing the hyperspectral image of the scanned line to obtain spectrum data for one or more pixels of the hyperspectral image of the scanned line; comparing the obtained spectrum data of the one or more pixels to predetermined spectrum data to determine whether the obtained spectrum data is indicative of foreign material within the scanned line of the agricultural product stream.

公开(公告)号：US09797844B2

公开(公告)日：2017-10-24

申请号：US14959073

申请日：2015-12-04

Applicant: Step Ahead Innovations, Inc.

Inventor： James E. Clark

IPC: G01N21/77 ,  A61K36/185 ,  G06Q30/02 ,  G01N21/27 ,  G01N21/64 ,  G01N27/06 ,  G01N21/85 ,  G01N33/18 ,  G01N21/78

CPC classification number: G01N21/77 ,  A61K36/185 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/78 ,  G01N21/8507 ,  G01N27/06 ,  G01N33/18 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/1211 ,  G01N2201/127 ,  G06Q30/0282

Abstract: A chemical indicator element for use in an aquatic environment water parameter testing system. The chemical indicator element includes a chemical indicator and a thin film material having particular optical characteristics tied to the light from a light source, such as a light source of an optical reader element of a water parameter testing system. The chemical indicator element may also include at least one of a backing material that absorbs one or more wavelengths of the light of the light source and a holder including a material that absorbs one or more wavelengths of the light of the light source.

公开(公告)号：US09797839B2

公开(公告)日：2017-10-24

申请号：US14738134

申请日：2015-06-12

Applicant: OLYMPUS CORPORATION

Inventor： Mitsushiro Yamaguchi

IPC: G01D18/00 ,  G01N21/64 ,  G01M11/00 ,  G01N21/27 ,  G02B21/00 ,  G02B21/34 ,  G01M11/02

CPC classification number: G01N21/645 ,  G01M11/00 ,  G01M11/02 ,  G01N21/274 ,  G01N21/276 ,  G01N21/278 ,  G01N21/6458 ,  G01N2201/06113 ,  G01N2201/127 ,  G01N2201/13 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/34

Abstract: An optical system of an optical analysis device is easily evaluated with high accuracy.There is provided a method of evaluating an optical analysis device including an optical system A capable of forming a confocal volume C at a focal position by condensing excitation light B, the method including the steps of: placing, at the focal position of the optical system A, a phantom sample in which two or more types of solid members having different fluorescent substance concentrations are arranged adjacent to each other; irradiating the phantom sample 1 with excitation light through the optical system A while relatively moving the confocal volume C formed by the optical system A and the phantom sample in an arrangement direction of the solid members; detecting fluorescent light generated in the solid members placed in the confocal volume C; and evaluating the optical system A based on the detected fluorescent light.

公开(公告)号：US20170284942A1

公开(公告)日：2017-10-05

申请号：US15470355

申请日：2017-03-27

Applicant: PLEXBIO CO., LTD.

Inventor： Cheng-Tse LIN ,  Yi-Ming SUN ,  Kuei-Shen HSU ,  Liang-Han CHANG ,  Yao-Kuang CHUNG ,  Chin-Yun WU ,  Chin-Shiou HUANG

IPC: G01N21/64 ,  C09B67/00 ,  C08F20/18 ,  C09K11/02 ,  C08K5/357 ,  B01L3/00 ,  C09K11/06

CPC classification number: G01N21/6452 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2200/148 ,  B01L2300/0829 ,  C08F20/18 ,  C08F120/14 ,  C08K5/357 ,  C09B69/101 ,  C09B69/103 ,  C09B69/105 ,  C09B69/109 ,  C09K11/02 ,  C09K11/06 ,  C09K2211/1033 ,  G01N21/278 ,  G01N21/6486 ,  G01N2201/127

Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.

公开(公告)号：US20170223197A1

公开(公告)日：2017-08-03

申请号：US15423301

申请日：2017-02-02

Applicant: Onyx Graphics, Inc.

Inventor： Maxim Wasyl Derhak ,  Lin Luo ,  Douglas Nolan Mackay ,  William Irel Chase ,  Lin Chen

IPC: H04N1/00 ,  G06K15/02 ,  H04N1/60 ,  G01N21/59 ,  G01N21/27

CPC classification number: H04N1/00087 ,  G01J3/462 ,  G01J3/506 ,  G01J3/524 ,  G01N21/274 ,  G01N21/59 ,  G01N2201/062 ,  G01N2201/127 ,  G06K15/027 ,  G06K2215/0094 ,  G06K2215/0097 ,  H04N1/00023 ,  H04N1/00034 ,  H04N1/00037 ,  H04N1/00058 ,  H04N1/6033 ,  H04N1/6097 ,  H04N2201/0082

Abstract: Systems, devices, and methods illuminate one or more areas on a calibration medium from a first side of the calibration medium with one or more respective light-emitting regions of a light source; detect light transmitted through the calibration medium at the one or more areas, thereby obtaining calibration-measurement information for at least one of the one or more light-emitting regions; illuminate one or more color patches on a color-measurement medium from a first side of the color-measurement medium with the one or more respective light-emitting regions of the light source; detect light transmitted through the one or more color patches printed on the color-measurement medium, thereby obtaining color-measurement information for at least one of the one or more light-emitting regions; and generate one or more transmissive measurements based on the calibration-measurement information and the color-measurement information.

公开(公告)号：US20170209080A1

公开(公告)日：2017-07-27

申请号：US15481868

申请日：2017-04-07

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea VARSAVSKY ,  Xiaolong LI ,  Mike C. LIU ,  Yuxiang ZHONG ,  Ning YANG

IPC: A61B5/1495 ,  A61B5/1459 ,  G01N33/49 ,  A61B5/00 ,  G01N21/84 ,  G01N27/27 ,  A61B5/1473 ,  A61B5/145 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170176478A1

公开(公告)日：2017-06-22

申请号：US15376704

申请日：2016-12-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Marcel Thomann

IPC: G01N35/00 ,  G01N21/27 ,  G01N35/02 ,  G01N21/55

CPC classification number: G01N35/00693 ,  G01N21/253 ,  G01N21/274 ,  G01N21/31 ,  G01N21/474 ,  G01N21/55 ,  G01N35/026 ,  G01N2201/127

Abstract: A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.

公开(公告)号：US20170176425A1

公开(公告)日：2017-06-22

申请号：US15300034

申请日：2015-02-05

Applicant: Becton, Dickinson and Company

Inventor： Ramez Emile Necola Shehada ,  Oliver Crespo-Diaz ,  Paul Limb

IPC: G01N33/543 ,  G01N35/00 ,  G01N21/64 ,  G01N15/10 ,  G01N15/14

CPC classification number: G01N33/54313 ,  G01N15/1012 ,  G01N15/1429 ,  G01N15/1459 ,  G01N21/64 ,  G01N35/00693 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2035/00673 ,  G01N2035/00702 ,  G01N2201/127

Abstract: One aspect relates to a method of calibrating event data. The method includes obtaining, via an electronic device including a processor, event data for an assay including a reagent. The reagent is associated with one of a plurality of manufacturing lots of the reagent. The method includes receiving one or more calibration factors for the reagent based on an identifier associated with the one of the plurality of manufacturing lots. The method further includes generating calibrated event data based on an application of the one or more calibration factors to the event data.

公开(公告)号：US20170160199A1

公开(公告)日：2017-06-08

申请号：US15437903

申请日：2017-02-21

Applicant: Affymetrix, Inc.

Inventor： Bei-Shen Sywe ,  Mark Borodkin ,  Chuan Gao ,  Liana Ilkova ,  Devin Nguyen

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/278 ,  G01N21/64 ,  G01N2201/127

Abstract: Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. Illumination of the fluorescent and/or reflective layers, and detection and analysis of the resulting emissions allows evaluation of the instrument with respect to both reflective and fluorescent channels. Selection of appropriate fluorescent materials for the one or more fluorescent layers allows the evaluation of an instrument with respect to different fluorophores, as would be used with an instrument capable of two color detection. Inclusion of a reflective layer further allows the evaluation and calibration of all optical channels of an instrument, including the reflective channel and two or more fluorescent channels, with a single calibration apparatus for imaging criteria such as uniformity, contrast and emission signal strength.