公开(公告)号：US20150168367A1

公开(公告)日：2015-06-18

申请号：US14132671

申请日：2013-12-18

Applicant: Thermo Scientific Portable Analytical Instruments Inc.

Inventor： Craig M. GARDNER ,  Michael BURKA

IPC: G01N33/22 ,  G01J3/02 ,  G01N21/65

CPC classification number: G01N33/227 ,  G01J3/027 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/0221

Abstract: A method of detecting an explosive material, and an analyzer and computer program products that may perform such methods. A method may include illuminating at least a portion of the material with light, and monitoring the temperature of the illuminated portion. T power or location of the illuminating light may be altered in response to the monitored temperature. Raman spectral data are produced in response to Raman radiation emitted from the portion in response to the light. The composition of the material may be analyzed based on the Raman spectral data or generating an indication to an operator that the material cannot be safely analyzed.

Abstract translation: 检测炸药的方法，以及可以执行这种方法的分析仪和计算机程序产品。 一种方法可以包括用光照射材料的至少一部分，并监测被照射部分的温度。 照亮光的功率或位置可以响应于所监视的温度而改变。 响应于从该部分响应于光发射的拉曼辐射而产生拉曼光谱数据。 可以基于拉曼光谱数据来分析材料的组成，或者向操作者产生不能安全地分析材料的指示。

公开(公告)号：US20150146202A1

公开(公告)日：2015-05-28

申请号：US14239039

申请日：2012-08-17

Applicant: E. Neil Lewis

Inventor： E. Neil Lewis

IPC: G01N21/51 ,  G01N21/65 ,  G01N15/02 ,  G01N15/14

CPC classification number: G01N21/51 ,  G01J3/44 ,  G01N15/0205 ,  G01N15/1434 ,  G01N21/65 ,  G01N21/80 ,  G01N2021/4709 ,  G01N2201/06113 ,  G01N2201/068

Abstract: The invention relates to methods and apparatus for detecting properties of suspended particles. Embodiments disclosed include an optical instrument (200) for detecting properties of a sample, comprising: a sample cell (103) for holding a sample of a particulate dispersion; a coherent light source (101) configured to illuminate the sample in the sample cell (103); a light intensity detector (104, 106) positioned to receive and measure an intensity of light from the coherent light source (101) elastically scattered by the sample in the sample cell (103); and a spectral light detector (212) positioned and configured to receive and measure a range of wavelengths of light from the coherent radiation source (101) inelastically scattered by the sample in the sample cell (103).

Abstract translation: 本发明涉及用于检测悬浮颗粒性质的方法和装置。 公开的实施例包括用于检测样品性质的光学仪器（200），包括：用于保持颗粒分散体样品的样品池（103）; 被配置为照射样品池中的样品的相干光源（101）; 定位成接收和测量由样品池（103）中的样品弹性散射的相干光源（101）的光强度的光强度检测器（104,106）; 以及光谱光检测器（212），其定位和配置为接收和测量来自所述样品池（103）中的所述样品被弹性散射的来自所述相干辐射源（101）的光的波长范围。

公开(公告)号：US08994938B2

公开(公告)日：2015-03-31

申请号：US13486846

申请日：2012-06-01

Applicant: David R. Day ,  Malcolm C. Smith ,  Peidong Wang

Inventor： David R. Day ,  Malcolm C. Smith ,  Peidong Wang

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/32

CPC classification number: G01J3/32 ,  G01J3/0229 ,  G01J3/0272 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/06113

Abstract: A Raman spectrometer including a laser excitation source, edge filters, and detection optics that direct light into a spectrograph. A spectrograph containing a dispersive element and optics that directs various wavelengths of light onto a segmented diffractive MEMS light modulator array. The MEMS array, depending on actuation state, directs light either to or away from a single detector. Control electronics drive the MEMS light modulator for either sequential wavelength measurement or multiplexed wavelength measurement (Hadamard for example).

公开(公告)号：US20150085278A1

公开(公告)日：2015-03-26

申请号：US14495233

申请日：2014-09-24

Applicant: Nutech Company Limited ,  Tsinghua University

Inventor： Zhiqiang CHEN ,  Li ZHANG ,  Jianhong ZHANG ,  Hongqiu WANG ,  Ziran ZHAO ,  Yumin YI ,  Jianping GU ,  Qingping HUANG

IPC: G01N21/47 ,  G01N33/15 ,  G01J3/44

CPC classification number: G01N21/47 ,  G01J3/44 ,  G01N21/65 ,  G01N21/658 ,  G01N33/15

Abstract: A raman spectrum measuring method for drug inspection is provided, comprising: measuring raman spectrum of a sample to be inspected to acquire an original raman spectrum curve of the sample; determining whether the original raman spectrum curve has a characterizing portion, and if not, measuring a mixture of the sample and an enhancing agent to acquire an enhanced raman spectrum curve of the sample; and if the original raman spectrum curve of the sample to be inspected has a characterizing portion, comparing the original raman spectrum curve of the sample with data in an original raman spectrum database of a drug to determine whether the sample contains the drug, otherwise, comparing the enhanced raman spectrum curve of the sample with data in an enhanced raman spectrum database of the drug to determine whether the sample to be inspected contains the drug.

Abstract translation: 提供了用于药物检查的拉曼光谱测量方法，包括：测量被检样品的拉曼光谱以获得样品的原始拉曼光谱曲线; 确定原始拉曼光谱曲线是否具有特征部分，如果不是，则测量样品和增强剂的混合物以获得样品的增强的拉曼光谱曲线; 如果要检查的样本的原始拉曼光谱曲线具有特征部分，则将样品的原始拉曼光谱曲线与药物的原始拉曼光谱数据库中的数据进行比较，以确定样品是否含有药物，否则比较 增强的拉曼光谱曲线的样品与增强的拉曼光谱数据库中的数据，以确定待检样品是否含有药物。

公开(公告)号：US08988680B2

公开(公告)日：2015-03-24

申请号：US13651600

申请日：2012-10-15

Applicant: ChemImage Corporation

Inventor： Matthew Nelson

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/32 ,  G01J3/44 ,  G01N21/31 ,  G01N21/35 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36 ,  G01N21/21 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A high passband transmission ratio is obtained by splitting a light beam from an objective lens into two orthogonally-polarized components processed along distinct paths through two independently controllable liquid crystal tunable filters (LCTFs). The filtered portions may be combined at an imaging plane or may be separately processed without recombining. Using two LCTFs, the arrangements discussed herein may ideally achieve 100% transmission in a single passband when two orthogonal components of a single wavelength are tuned, or 50% transmission at two distinct passbands when two orthogonal components from two different wavelengths (one component from each wavelength) are tuned. The dual polarization configuration described herein may be used to improve contrast or detected signal intensity in various microscopy and spectroscopic/chemical imaging applications and to increase the speed of detection.

Abstract translation: 通过将来自物镜的光束分成通过两个独立可控的液晶可调滤波器（LCTF）沿不同路径处理的两个正交极化分量，获得高通带传输比。 过滤部分可以在成像平面处组合，或者可以在不重新组合的情况下分开处理。 使用两个LCTF，当两个不同波长的两个正交分量（来自两个不同波长的一个分量）（两个不同波长的两个正交分量） 波长）调整。 本文描述的双极化配置可用于改善各种显微镜和分光/化学成像应用中的对比度或检测信号强度，并提高检测速度。

公开(公告)号：US20150057549A1

公开(公告)日：2015-02-26

申请号：US14322517

申请日：2014-07-02

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Benjamin A. Flusberg ,  Eric David Cocker ,  Juergen Claus Jung ,  Mark Jacob Schnitzer

IPC: A61B5/00

CPC classification number: A61B5/0068 ,  A61B5/0013 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0079 ,  A61B5/4064 ,  A61B5/6814 ,  A61B2503/40 ,  A61B2576/026 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/65

Abstract: Analysis of live beings is facilitated. According to an example embodiment of the present invention, a light-directing arrangement such as an endoscope is mounted to a live being. Optics in the light-directing arrangement are implemented to pass source light (e.g., laser excitation light) into the live being, and to pass light from the live being for detection thereof. The light from the live being may include, for example, photons emitted in response to the laser excitation light (i.e., fluoresced). The detected light is then used to detect a characteristic of the live being.

Abstract translation: 生活分析方便。 根据本发明的示例性实施例，诸如内窥镜的导光装置安装在活体上。 实现光导布置中的光学器件将源光（例如，激光激发光）传送到活体中，并且传递来自活体的光以进行检测。 来自活体的光可以包括例如响应于激光激发光（即，发荧光）而发射的光子。 然后使用检测到的光来检测活体的特征。

公开(公告)号：US20150029326A1

公开(公告)日：2015-01-29

申请号：US14339239

申请日：2014-07-23

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Vadim Backman ,  Hariharan Subramanian ,  John E. Chandler ,  Craig White ,  Jeremy D. Rogers ,  Lusik Cherkezyan

IPC: G03B13/36 ,  H04N5/235 ,  G06K9/00 ,  G02B21/36

CPC classification number: G06K9/00127 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/47 ,  G01N2021/4709 ,  G02B21/06 ,  G02B21/16 ,  G02B21/365 ,  H04N5/23212 ,  H04N5/2354

Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.

Abstract translation: 本技术提供方法，系统和设备，以实现部分波谱（PWS）显微镜图像的高吞吐量和高速采集。 特别地，本文提供了能够快速获取PWS显微镜图像及其临床，诊断和研究应用的高通量，自动部分波谱（HT / A-PWS）仪器和系统。

公开(公告)号：US08937716B2

公开(公告)日：2015-01-20

申请号：US14344141

申请日：2011-09-14

Applicant: Qiang Wu ,  James Gerard Masters

Inventor： Qiang Wu ,  James Gerard Masters

IPC: G01J3/44 ,  A61B5/00 ,  G01N21/65

CPC classification number: G01N21/65 ,  A61B5/222 ,  A61B5/4266 ,  G01J3/44

Abstract: A method to assess perspiration reduction of a composition comprising obtaining an amount of water in stratum corneum in a first area of skin on an individual using confocal Raman spectroscopy, applying a composition to the first area of skin on the individual, having the individual perform an activity to cause the individual to perspire, and obtaining an amount of water in stratum corneum in the first area of skin on the individual after the activity using confocal Raman spectroscopy.

Abstract translation: 一种评估组合物排汗减少的方法，其包括使用共聚焦拉曼光谱法获得个体皮肤第一区域中的角质层中的水量，将组合物施用于个体的皮肤第一区域，其具有个体进行 导致个体出汗的活动，并且在使用共聚焦拉曼光谱法的活动之后，在个体的皮肤的第一区域中获得角质层中的水量。

公开(公告)号：US08934094B2

公开(公告)日：2015-01-13

申请号：US13757411

申请日：2013-02-01

Applicant: Sony Corporation

Inventor： Suguru Dowaki ,  Kazuhiro Nakagawa ,  Eriko Matsui

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/65

Abstract: The present disclosure provides a method of measuring a Raman scattered light which is capable of detecting a Raman scattered light derived from a specimen at a high sensitivity, and a container for a Raman scattered light measurement specimen for use therein. The method of measuring a Raman scattered light includes radiating an exciting light to a specimen on a sheet member made of a material different from a material of an accommodating section and disposed within the accommodating section, thereby detecting a Raman scattered light.

Abstract translation: 本公开内容提供了一种测量能够以高灵敏度检测来自样本的拉曼散射光的拉曼散射光的测量方法和用于其中的拉曼散射光测量样本的容器。 测量拉曼散射光的方法包括：将激励光照射到由不同于容纳部的材料的材料制成的片材上，并设置在容纳部内，从而检测拉曼散射光。

公开(公告)号：US08934093B2

公开(公告)日：2015-01-13

申请号：US13401199

申请日：2012-02-21

Applicant: Pi Ling Huang ,  Kuang-Yu Hsu ,  Cheng-Kai Wang ,  Edmund Sun ,  Sheng-Lung Huang

Inventor： Pi Ling Huang ,  Kuang-Yu Hsu ,  Cheng-Kai Wang ,  Edmund Sun ,  Sheng-Lung Huang

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  H01S3/067 ,  H01S3/0941 ,  H01S3/16 ,  H01S5/323

CPC classification number: G01J3/0218 ,  G01J3/0245 ,  G01J3/10 ,  G01J3/44 ,  H01S3/06716 ,  H01S3/09415 ,  H01S3/1623 ,  H01S3/1625 ,  H01S3/1636 ,  H01S5/32341

Abstract: The invention relates to a crystal fiber, a Raman spectrometer using the same and a inspection method thereof. The crystal fiber comprises a sapphire crystal is doped with two transition metals having different concentrations. An excitation light beam at a specific wavelength can propagate along the crystal fiber to generate a narrow-band light beam and a wide-band light beam to project on a specimen. Raman scattered light is emitted from the specimen. The wavelength of the Raman scattered light falls within the wavelength range of the wide-band light beam so that the wide-band light beam is enhanced at some characteristic wavelengths to facilitate Raman spectroscopy.

Abstract translation: 本发明涉及一种晶体纤维，使用其的拉曼光谱仪及其检查方法。 晶体纤维包含蓝宝石晶体，其掺杂有两种不同浓度的过渡金属。 特定波长的激发光束可以沿着晶体光纤传播，以产生窄带光束和宽带光束投影在样本上。 拉曼散射光从样品中排出。 拉曼散射光的波长落在宽带光束的波长范围内，使得宽带光束在某些特征波长处被增强以促进拉曼光谱。