公开(公告)号：US09568439B2

公开(公告)日：2017-02-14

申请号：US15088673

申请日：2016-04-01

Applicant: Hitachi High-Technologies Corporation

Inventor： Toshifumi Honda ,  Yuta Urano ,  Takahiro Jingu ,  Akira Hamamatsu

IPC: G01N21/00 ,  G01N21/95 ,  G01N21/956 ,  G01J1/04

CPC classification number: G01N21/8806 ,  G01J1/0474 ,  G01J1/44 ,  G01N21/9501 ,  G01N21/956 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/0683 ,  G01N2201/0697 ,  G01N2201/10 ,  G01N2201/12

Abstract: To detect an infinitesimal defect, highly precisely measure the dimensions of the detect, a detect inspection device is configured to comprise: a irradiation unit which irradiate light in a linear region on a surface of a sample; a detection unit which detect light from the linear region; and a signal processing unit which processes a signal obtained by detecting light and detecting a defect. The detection unit includes: an optical assembly which diffuses the light from the sample in one direction and forms an image in a direction orthogonal to the one direction; and a detection assembly having an array sensor in which detection pixels are positioned two-dimensionally, which detects the light diffused in the one direction and imaged in the direction orthogonal to the one direction, adds output signals of each of the detection pixels aligned in the direction in which the light is diffused, and outputs same.

Abstract translation: 为了检测无限小的缺陷，高度精确地测量检测器的尺寸，检测检查装置被配置为包括：照射单元，其照射样品表面上的线性区域中的光; 检测单元，其检测来自所述线性区域的光; 以及处理通过检测光而获得的信号并检测缺陷的信号处理单元。 检测单元包括：光学组件，其在一个方向上扩散来自样品的光并在与该一个方向正交的方向上形成图像; 以及检测组件，其具有阵列传感器，其中检测像素被二维地定位，其检测沿与所述一个方向正交的方向成像的沿所述一个方向扩散的光，并将每个所述检测像素的输出信号相加 光漫射的方向，并输出。

公开(公告)号：US09568419B2

公开(公告)日：2017-02-14

申请号：US14624905

申请日：2015-02-18

Applicant: PASON SYSTEMS CORP.

Inventor： Jason Alexander DeGreeve ,  Sean William Lyons Unrau ,  Marceau Ernest van Beurden ,  Ryan Henricus van Beurden

IPC: E21B49/00 ,  G06F19/00 ,  G01N21/35 ,  G01N21/3504 ,  B01D19/00 ,  E21B21/06 ,  G01V8/02

CPC classification number: G01N21/3504 ,  B01D19/0042 ,  B01D19/0052 ,  E21B21/067 ,  E21B49/00 ,  E21B49/005 ,  E21B49/084 ,  E21B2049/085 ,  G01N21/35 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/12 ,  G01V8/02 ,  G01V8/10

Abstract: A method for analyzing a gas sample conveyed in a drilling fluid involves liberating the gas sample from the drilling fluid, irradiating the gas sample with infrared radiation spanning a wavelength range in the near-infrared range, detecting absorption spectra associated with irradiating the gas sample, and determining a composition of the gas sample from the absorption spectra. The gas sample includes one or more of methane, ethane, propane, and butane, the detected absorption spectra are associated with irradiating each of the one or more of methane, ethane, propane, and butane, and the composition includes a concentration of any one or more of the methane, ethane, propane, and butane.

Abstract translation: 用于分析在钻井液中输送的气体样品的方法包括从钻井液中释放气体样品，用在近红外范围的波长范围内的红外辐射照射气体样品，检测与照射气体样品相关的吸收光谱， 以及从吸收光谱确定气体样品的组成。 气体样品包括甲烷，乙烷，丙烷和丁烷中的一种或多种，​​所检测的吸收光谱与辐射甲烷，乙烷，丙烷和丁烷中的一种或多种的相关联，并且组合物包括任何一种 或更多的甲烷，乙烷，丙烷和丁烷。

公开(公告)号：US20170035308A1

公开(公告)日：2017-02-09

申请号：US15233474

申请日：2016-08-10

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: A61B5/024 ,  G01N21/359 ,  G01N21/49 ,  A61B5/00 ,  G01N33/49 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/3577 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for measurement of heart rate and other heart-related characteristics a photoplethysmogram (PPG) obtained from a tissue is divided into several feature waveforms, each corresponding to a PPG window of a particular length. Conditioned features, containing frequency components specific to heart-related events, are derived from the features by modulating a carrier kernel with such features. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. For each conditioned feature, one or more collisions selectively amplify frequency components in features sourced from PPG, and respective energy change values are obtained from such amplified energy portions. The resulting energy change values are analyzed to determine a smallest time-window likely containing heart rate and other heart-related events in the PPG data stream. Over time, the detected events are grouped and analyzed to determine heart rate and other heart-related characteristics.

Abstract translation: 在用于测量心率和其他心脏相关特征的非侵入性系统中，从组织获得的光谱体积图（PPG）被分成几个特征波形，每个特征波形对应于特定长度的PPG窗口。 包含与心脏相关事件特定的频率分量的条件特征是通过使用这些特征调制载体内核从特征得出的。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 对于每个调节特征，一个或多个碰撞选择性地放大来自PPG的特征中的频率分量，并且从这种经放大的能量部分获得各自的能量变化值。 分析所得到的能量变化值以确定可能包含PPG数据流中的心率和其他心脏相关事件的最小时间窗口。 随着时间的推移，检测到的事件被分组和分析，以确定心率和其他心脏相关特征。

公开(公告)号：US20170030874A1

公开(公告)日：2017-02-02

申请号：US15294877

申请日：2016-10-17

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N30/78 ,  G01N21/33

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

公开(公告)号：US20170030839A1

公开(公告)日：2017-02-02

申请号：US15290020

申请日：2016-10-11

Applicant: Keyence Corporation

Inventor： Hajime Matsuda

IPC: G01N21/88 ,  G06K9/20 ,  G06K9/32 ,  G06T7/00

CPC classification number: G01N21/8806 ,  G01N21/8851 ,  G01N2021/845 ,  G01N2201/062 ,  G01N2201/12 ,  G06K9/2027 ,  G06K9/325 ,  G06T7/0004 ,  G06T7/0008 ,  G06T7/586 ,  G06T2207/10152 ,  G06T2207/20016 ,  G06T2207/20221 ,  G06T2207/30164

Abstract: To facilitate adjusting of a distance from an inspection target to an illumination section by providing a movable illumination section that is movable independently of the imaging section. An illumination apparatus has a plurality of LEDs arranged in a substantially annular form, a light diffusion member for diffusing light emitted from the plurality of LEDs, and a lighting control part for lighting the plurality of light sources in accordance with a predetermined lighting pattern when designated to start lighting. In particular, the illumination apparatus moves independently of a camera to adjust a distance to a workpiece.

Abstract translation: 通过提供可独立于成像部分移动的可移动照明部分，便于调整从检查对象到照明部分的距离。 照明装置具有以大致环状形式配置的多个LED，用于扩散从多个LED发射的光的光漫射构件，以及用于在指定时根据预定的照明模式点亮多个光源的照明控制部 开始照明 特别地，照明装置独立于相机移动以调整到工件的距离。

公开(公告)号：US09546952B2

公开(公告)日：2017-01-17

申请号：US14490242

申请日：2014-09-18

Applicant: Massachusetts Institute of Technology

Inventor： Wonshik Choi ,  Ramachandra Dasari ,  Christopher Fang-Yen ,  Michael Feld

IPC: G01N21/45 ,  G01N21/51 ,  G01N21/64

CPC classification number: G01N21/45 ,  G01N21/51 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/458 ,  G01N2201/061 ,  G01N2201/105 ,  G01N2201/12

Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.

Abstract translation: 本发明涉及使用具有可变照明角度的移相激光干涉显微镜对活体或非活细胞，组织或微生物中的折射率进行定量三维映射的系统和方法。 优选的实施方案提供细胞和多细胞生物的层析成像，以及在组织光散射中具有多种应用的高分辨率显微镜中细胞结构的时间依赖性变化和样品诱导的像差的定量表征。

公开(公告)号：US20170010453A1

公开(公告)日：2017-01-12

申请号：US15275359

申请日：2016-09-24

Applicant: OLYMPUS CORPORATION

Inventor： Kentaro IMOTO ,  Shinichi TAKIMOTO ,  Shintaro TAKAHASHI ,  Atsushi DOI

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G02B21/0076 ,  G01N21/6458 ,  G01N2201/06113 ,  G01N2201/1053 ,  G01N2201/12 ,  G02B21/0032 ,  G02B21/006 ,  G02B21/0068 ,  G02B21/008 ,  G02B21/0084

Abstract: Provided is a microscope provided with: a scanner that scans an excitation beam coming from a light source; an objective optical system that focuses the scanned excitation beam onto a sample and that collects fluorescence generated at individual scanning positions in the sample; a detector that detects the collected fluorescence; a light blocking member that is disposed between the detector and the system and that partially blocks the collected fluorescence; a switching portion that switches the positional relationship between the member and a light-focusing point of the excitation beam in the sample between an optically conjugate positional relationship, in which an in-focus fluorescence generated at the light-focusing point passes through the member, and a non-conjugate positional relationship, in which the in-focus fluorescence is blocked by the member; and a computing portion that computes a difference between fluorescence signals acquired by the detector in the two positional relationships.

Abstract translation: 提供了一种显微镜，其具有：扫描来自光源的激发光束的扫描仪; 物镜光学系统，其将扫描的激发光束聚焦到样品上并且收集样品中各个扫描位置产生的荧光; 检测所收集的荧光的检测器; 光阻挡构件，其设置在所述检测器和所述系统之间并部分阻挡所述收集的荧光; 切换部，其以在所述光聚合点处产生的聚焦荧光透过所述构件的光学共轭位置关系之间切换所述构件与所述样品中的所述激发光束的聚光点之间的位置关系， 以及非共轭位置关系，其中聚焦荧光被构件阻挡; 以及计算部分，其计算由两个位置关系中的检测器获取的荧光信号之间的差异。

公开(公告)号：US20170010210A1

公开(公告)日：2017-01-12

申请号：US15272696

申请日：2016-09-22

Applicant: KNU-INDUSTRY COOPERATION FOUNDATION

Inventor： Myoung-Gun CHOUNG

IPC: G01N21/359 ,  G01N33/02 ,  G01N21/27

CPC classification number: G01N21/359 ,  G01N21/25 ,  G01N21/274 ,  G01N21/31 ,  G01N33/02 ,  G01N2201/12

Abstract: A method is for simultaneously analyzing nutritional component content in a plurality of various foods or agricultural sources having different ingredients and forms, that is, different physicochemical properties and compositions distributed in Korea by near-infrared reflectance spectroscopy. In particular, a method is for rapidly and accurately measuring nutritional component content in a plurality of various foods or agricultural sources having different ingredients and forms, that is, different physicochemical properties and compositions distributed in Korea by near-infrared reflectance spectroscopy.

Abstract translation: 一种方法是同时分析具有不同成分和形式的多种各种食品或农业来源的营养成分含量，即通过近红外反射光谱法分散在韩国的不同的理化性质和组成。 特别地，一种方法是通过近红外线反射光谱法快速，准确地测量多种具有不同成分和形式的各种食品或农业来源的营养成分含量，即分散在韩国的不同的物理化学性质和组成。

公开(公告)号：US20170003293A1

公开(公告)日：2017-01-05

申请号：US15100056

申请日：2014-11-25

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Jiangbo Yu

IPC: G01N33/58 ,  C09K11/06 ,  G01N21/64 ,  C09K11/02

CPC classification number: G01N33/58 ,  C09B23/0066 ,  C09B23/04 ,  C09B57/007 ,  C09B69/109 ,  C09K11/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1044 ,  C09K2211/1416 ,  C09K2211/182 ,  G01N21/6408 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/587 ,  G01N33/588 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/12

Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

Abstract translation: 本公开提供了能够例如分析物的光学和/或生物分子编码的经编码的发色聚合物颗粒。 本公开还提供了包含多个编码的发色聚合物颗粒的悬浮液。 本公开还提供了使用经编码的发色聚合物颗粒和系统用编码的发色聚合物颗粒进行多重分析的方法。

公开(公告)号：US09535009B2

公开(公告)日：2017-01-03

申请号：US14401455

申请日：2013-04-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kenshiro Ohtsubo ,  Hidetoshi Nishiyama ,  Takahiro Jingu ,  Masaaki Ito

IPC: G01N21/84 ,  G01N21/88 ,  G01N21/95 ,  G01N21/956

CPC classification number: G01N21/8806 ,  G01N21/8851 ,  G01N21/9501 ,  G01N21/95623 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/12

Abstract: To improve sensitivity of a defect inspection, it is required to decrease influence of excessive diffraction from a spatial filter. Further, it is preferable to secure signal intensity from defects and particles as much as possible, while the influence of the excessive diffraction is decreased as much as possible. The present invention is characterized in setting a width of a spatial filter surface such that an unnecessary image caused by diffraction, that is, an intensity of the excessive diffraction is sufficiently small with respect to an intensity of a desired image. In the present invention, an SN ratio that is an index for deciding a width of the spatial filter is calculated from a region subjected to the influence of the excessive diffraction in an inspection image, and a width of a shield unit of the spatial filter is set so as to maximize the SN ratio.

Abstract translation: 为了提高缺陷检查的灵敏度，需要减小空间滤波器过度衍射的影响。 此外，尽可能地尽可能地减少来自缺陷和颗粒的信号强度，同时尽可能地减少过度衍射的影响。 本发明的特征在于设置空间滤波器表面的宽度，使得由衍射引起的不需要的图像，即过度衍射的强度相对于期望的图像的强度足够小。 在本发明中，作为用于决定空间滤波器的宽度的指标的SN比是从检查图像中受到过度衍射的影响的区域算出的，空间滤波器的屏蔽单位的宽度为 设置为最大化SN比。