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公开(公告)号：US11384136B2
公开(公告)日：2022-07-12
申请号：US16674003
申请日：2019-11-05
Applicant: UCB BIOPHARMA SPRL
Inventor： Jean-Pascal Pierre Bilgischer , Philip Jonathan Bassett , Mark Robert Pearce-Higgins , Andrew John Kenny
Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
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公开(公告)号：US11286312B2
公开(公告)日：2022-03-29
申请号：US15779417
申请日：2016-12-01
Applicant: UCB BIOPHARMA SPRL
Inventor： Pallavi Bhatta , Laura Starkie , Michael John Wright
IPC: C07K16/46 , C07K16/14 , C07K14/395 , C07K16/00 , C12N15/10
Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.
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公开(公告)号：US11059820B2
公开(公告)日：2021-07-13
申请号：US16615992
申请日：2018-05-24
Applicant: UCB BIOPHARMA SPRL
Inventor： Luc Lambert Jozef Jan Aerts , Georges Assaf , Nicolas Edmond Carly , Vincent Adolphe Carol Cool , Jean-Pierre Delatinne , Laurent Jacques Willy Delhaye , Jean Paul Kestemont , Sarah Le Meur
IPC: C07D471/04 , A61K31/519 , A61P3/00 , A61P9/00
Abstract: Crystalline forms of seletalisib, designated as Form B and Form F and characterized herein, being selective inhibitors of PI3 kinase enzymes, in particular of the human PBKδ isoform, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
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公开(公告)号：US10774152B2
公开(公告)日：2020-09-15
申请号：US15326499
申请日：2015-07-16
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
Abstract: The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.
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公开(公告)号：US20200283416A1
公开(公告)日：2020-09-10
申请号：US15774332
申请日：2016-11-24
Applicant: UCB Biopharma SPRL
Inventor： Rebecca Louise Charlton , Teresa De Haro Garcia , Martin Alexander Lowe , Malcolm Maccoss , Trevor Morgan , Richard David Taylor , Zhaoning Zhu
IPC: C07D403/10 , C07D471/04 , C07D417/10
Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.
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Patent Agency Ranking
公开(公告)号：US20190330327A1
公开(公告)日：2019-10-31
申请号：US16470999
申请日：2017-12-13
Applicant: UCB BIOPHARMA SPRL , SANOFI
Inventor： Alastair David Griffiths LAWSON , Daniel John LIGHTWOOD , Rebecca Jayne MUNRO , James Philip O'CONNELL , John Robert PORTER
IPC: C07K16/24
Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号：US20190322739A1
公开(公告)日：2019-10-24
申请号：US16402097
申请日：2019-05-02
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret FINNEY , Stephen Edward RAPECKI , Michael John WRIGHT
Abstract: The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry.
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公开(公告)号：US20190284267A1
公开(公告)日：2019-09-19
申请号：US16409945
申请日：2019-05-13
Applicant: UCB BIOPHARMA SPRL
Inventor： DAVID EDWARD ORMONDE KNIGHT , TERENCE SEWARD BAKER , DAVID JAMES MCMILLAN , ROBERT ANTHONY GRIFFIN , GEORGES MAIRET-COELLO , PATRICK DOWNEY , JEAN-PHILIPPE COURADE
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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公开(公告)号：US20190284170A1
公开(公告)日：2019-09-19
申请号：US16349734
申请日：2017-12-08
Applicant: UCB Biopharma SPRL
Inventor： Jag Paul Heer
IPC: C07D403/04
Abstract: 2-(5-{1-[2-(Difluoromethoxy)-6-fluorobenzyl]-2-methyl-1H-benzimidazol-6-yl}pyrimidin-2-yl)propan-2-ol, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20190270811A1
公开(公告)日：2019-09-05
申请号：US16299407
申请日：2019-03-12
Applicant: UCB BIOPHARMA SPRL
Inventor： Paul Alan ATHERFOLD , Thomas Allen CESKA , Helene Margaret FINNEY , Lara KEVORKIAN , Kaushik SARKAR , Bryan John SMITH , Kerry Louise TYSON
Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
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