公开(公告)号：US11523921B2

公开(公告)日：2022-12-13

申请号：US15945397

申请日：2018-04-04

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Il Kim ,  So Ri Lee ,  Ji Yeon Lee ,  Gyo Yeon Hwang

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/08 ,  A61L31/02 ,  A61K9/00 ,  A61F2/90 ,  A61K31/704 ,  B05D3/06 ,  B05D1/18 ,  B05D3/10 ,  B05D3/12

Abstract: The present disclosure provides a method for producing a multifunctional implantable structure, the method having: preparing an implantable base; coating a polymer layer on the base, wherein the polymer layer is partially curable; curing the polymer layer such that the polymer layer has cured and non-cured portions; and dry-etching the polymer layer to remove the non-cured portion thereof, to allow the polymer layer to have a nano-turf structure having pores defined therein.

公开(公告)号：US11520091B2

公开(公告)日：2022-12-06

申请号：US16684016

申请日：2019-11-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Young Byun ,  So Hye Cho ,  Seung Yong Lee ,  Kwang-Deok Choi ,  In Uk Baek ,  Yun Hee Kim

IPC: C23C14/00 ,  G02B5/28 ,  C23C14/08 ,  C23C14/06 ,  B32B15/00 ,  B32B3/10 ,  B32B3/12

Abstract: Provided is a coloring pattern structure. The coloring pattern structure includes: a substrate; a light-transmitting dielectric layer formed on at least one surface of the substrate; and a composite material layer disposed on an upper surface of the light-transmitting dielectric layer and formed of a metal and a first material not having a thermodynamic solid solubility in the metal, wherein the metal included in the composite material layer has a pattern coated only on portions of the upper surface of the light-transmitting dielectric layer, and the first material is coated on the remaining area where the metal is not coated.

公开(公告)号：US11513032B2

公开(公告)日：2022-11-29

申请号：US16792886

申请日：2020-02-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yong Bok Lee ,  Wonil Kwak ,  Junsang Kong ,  Jungwan Kim ,  Yunseok Ha

IPC: G01M13/045 ,  F16C41/00 ,  H02N2/18 ,  H04W4/38

Abstract: Provided is a system for real-time condition diagnosis of a bearing module including a self-power generation module installed in an outer ring of a bearing to generate electricity using vibration generated from a micro whirling motion of the bearing, a behavior detection unit installed in the bearing to detect behavior information of the bearing in real time, a wireless transmission module connected to the behavior detection unit to transmit the real-time detected behavior information of the bearing to an external device, and a condition diagnosis unit that receives the behavior information of the bearing transmitted from the wireless transmission module and diagnoses condition of the bearing in real time, wherein the real-time behavior information of the behavior detection unit installed in the bearing is transmitted through the electricity obtained by the self-power generation module.

公开(公告)号：US11510868B2

公开(公告)日：2022-11-29

申请号：US16672518

申请日：2019-11-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jinseok Kim ,  Yong-Won Song ,  Hyungdal Park ,  Ockchul Kim

IPC: A61F9/00 ,  A61K9/00 ,  A61N1/04 ,  A61N1/32 ,  G02C7/04

Abstract: Provided is a smart contact lens for non-invasive drug delivery including a platform configured to be worn on an eye, a reservoir installed within the platform, and having a receiving part in which a drug is received, to provide the eye with the drug, an electrode for iontophoresis installed in the reservoir to make iontophoresis work, to provide the eye with the drug from the reservoir, and an activation chip electrically connected to the electrode for iontophoresis to activate iontophoresis.

公开(公告)号：US20220362748A1

公开(公告)日：2022-11-17

申请号：US17816154

申请日：2022-07-29

Applicant: Korea Institute of Science and Technology

Inventor： Young Suk JO ,  Jun Young CHA ,  Hyang Soo JEONG ,  Yong Min KIM ,  Hyun Tae SOHN ,  Sung Pil YOON ,  Suk Woo NAM ,  Taik Jin LEE ,  Chang Won YOON ,  Jong Hee HAN

IPC: B01J23/46 ,  B01J27/24 ,  B01J35/08 ,  B01J35/02 ,  B01J35/00 ,  B01J37/02 ,  B01J37/08 ,  C01B3/04 ,  C01B3/02 ,  C01C1/04

Abstract: The present invention relates to a catalyst in which a catalytic metal is supported on a support including a single-crystalline hexagonal material, and a preparation method therefor, wherein the catalyst can be effectively used in ammonia dehydrogenation or ammonia synthesis.

公开(公告)号：US11498976B2

公开(公告)日：2022-11-15

申请号：US16878672

申请日：2020-05-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyung Jun Ahn ,  Sungjin Lee

IPC: C07H21/04 ,  C07K16/30 ,  A61P35/00 ,  C12N15/86

Abstract: The present invention relates to a viral complex comprising a viral vector capable of delivering shRNA that suppresses an expression of epidermal growth factor receptor (EGFR) to a cell and an anti-epithelial cell adhesion molecule (EpCAM) antibody conjugated to the viral vector, a pharmaceutical composition for preventing or treating cancer, comprising the viral complex, and a method for treating cancer, comprising administering the viral complex or the pharmaceutical composition to a subject in which a cancer disease has occurred and overexpressing EpCAM. The anti-EpCAM antibody-AAV2/shEGFR complex provided in the present invention significantly reduces the expression level of EGFR in tumor cells overexpressing EpCAM without inducing an immune response in vivo, thereby inducing death of tumor cells, and thus, it can be widely utilized in more effective and safe cancer treatment.

公开(公告)号：US11498946B2

公开(公告)日：2022-11-15

申请号：US17118767

申请日：2020-12-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwangmeyung Kim ,  Ju Hee Ryu ,  Hong Yeol Yoon ,  Man Kyu Shim ,  Suah Yang

IPC: C07K14/47 ,  A61P35/00 ,  A61K47/10 ,  C07K16/28 ,  A61K47/64

Abstract: The present disclosure relates to a pharmaceutical composition for combination therapy for preventing or treating cancer, which contains a first pharmaceutical ingredient containing a drug conjugate wherein an anticancer agent is bound at one end of an amphiphilic peptide represented by SEQ ID NO 1 and a poloxamer; and a second pharmaceutical ingredient containing an anti-PD-L1 antibody; as active ingredients. The pharmaceutical composition significantly inhibits cancer growth in in-vivo experiments and exhibits an effect of significantly enhancing immunotherapeutic effect by activating immune cells in cancerous tissues.
In particular, the pharmaceutical composition for combination therapy according to the present disclosure has superior tumor accumulation efficiency and selectivity as compared to existing anticancer agents, and is very stable with little toxicity to normal tissues other than cancerous tissues.

公开(公告)号：US11492363B2

公开(公告)日：2022-11-08

申请号：US16395235

申请日：2019-04-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyung Youl Baek ,  Chong Min Koo ,  Soon Man Hong ,  Seung Sang Hwang ,  Sangho Cho ,  Jin Young Seo ,  Do Xuan Huy ,  Younghan Song ,  Sejin Kim ,  Changju Sung ,  Yeojin Ahn

IPC: B01J21/06 ,  C07F7/00 ,  A62D3/35 ,  A62D5/00 ,  A62D9/00 ,  A62B18/02 ,  B01J35/10 ,  B01J35/02 ,  B01J31/12 ,  A62B7/10 ,  A62D101/02

Abstract: The present invention relates to a method for preparing size-modulated UiO-66, which is achieved by modulating the concentrations of reactants, and a catalyst with improved activity of hydrolyzing chemical warfare agents prepared by the method.

公开(公告)号：US20220347644A1

公开(公告)日：2022-11-03

申请号：US17859485

申请日：2022-07-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Suk JO ,  Chang Won YOON ,  Hyuntae SOHN ,  Hyangsoo JEONG ,  Seong Cheol JANG ,  Yeong Cheon KIM ,  Jonghee HAN ,  Suk Woo NAM

IPC: B01J8/02 ,  B01J19/24 ,  B01J23/46 ,  B01J23/10 ,  B01J29/08 ,  B01J35/04 ,  B01J35/00 ,  C01B3/04 ,  H01M8/0606 ,  B01J23/648

Abstract: The present specification discloses a membrane reactor comprising a reaction region; a permeate region; and a composite membrane disposed at a boundary of the reaction region and the permeate region, wherein the reaction region comprises a bed filled with a catalyst for dehydrogenation reaction, wherein the composite membrane comprises a support layer including a metal with a body-centered-cubic (BCC) crystal structure, and a catalyst layer including a palladium (Pd) or a palladium alloy formed onto the support layer, wherein ammonia (NH3) is supplied to the reaction region, the ammonia is converted into hydrogen (H2) by the dehydrogenation reaction in the presence of the catalyst for dehydrogenation reaction, and the hydrogen permeates the composite membrane and is emitted from the membrane reactor through the permeate region.

公开(公告)号：US11486777B2

公开(公告)日：2022-11-01

申请号：US17259636

申请日：2019-07-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jinseok Kim ,  Sungwook Yang ,  Min Su Jang ,  Jun Sik Kim ,  Kyumin Kang ,  Bum-Jae You

IPC: G01L1/24 ,  G01L3/12

Abstract: Embodiments relate to a torsion sensor device which measures a degree of torsion of a measurement object by using a fiber Bragg gratings (FBG) sensor, the sensor device comprising: an FBG sensor including a sensing unit formed in one section of an elongated optical fiber; and a fixing device for fixing and supporting the FBG sensor to cause displacement of the FBG sensor according to motion of the measurement object, wherein the fixing device includes a bending prevention member to enable the sensing unit to have torsion displacement without bending displacement, according to the motion of the measurement object.