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公开(公告)号：US11673908B2
公开(公告)日：2023-06-13
申请号：US17878650
申请日：2022-08-01
Inventor： Andrea Choe , Paul W. Sternberg , Frank C. Schroeder , Stephan H. Von Reuss
IPC: A61K31/7028 , C07H15/04 , A01N37/36 , A61K31/454 , C07H15/08 , C07H15/10 , C07H15/18 , C07H15/26 , A01N43/16 , A01N43/38 , C07D309/10
CPC classification number: C07H15/04 , A01N37/36 , A01N43/16 , A01N43/38 , A61K31/454 , A61K31/7028 , C07H15/08 , C07H15/10 , C07H15/18 , C07H15/26 , C07D309/10
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
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公开(公告)号：US11668613B2
公开(公告)日：2023-06-06
申请号：US16404543
申请日：2019-05-06
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Luca Bonanomi , Vincenzo Costanza , Chiara Daraio , Zhun Zhou
IPC: G01K17/20 , B32B27/28 , B32B27/30 , B32B7/027 , C08L33/08 , C08L83/04 , G01N27/30 , C08L53/00 , C08F265/02 , C08F265/06 , C08F265/04 , C08F2/42
CPC classification number: G01K17/20 , B32B7/027 , B32B27/281 , B32B27/283 , B32B27/308 , C08F2/42 , C08F265/02 , C08F265/04 , C08F265/06 , C08L33/08 , C08L53/00 , C08L83/04 , G01N27/307 , B32B2307/206 , B32B2307/51 , B32B2457/00 , C08L2203/206 , C08F220/1804 , C08F220/06 , C08F220/20
Abstract: ABA type block copolymers as a new class of temperature sensing polymers with tunable, high temperature coefficient of resistance (TCR). A sensor includes a heater, a thermal insulator between two thermometer layers, the heater generating a thermal gradient within the thermal insulator. The thermometers give an indirect measurement of fluid flow around the sensor, based on their temperature readings. The thermometers are flexible layers including ABA block polymers.
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公开(公告)号：US11667676B2
公开(公告)日：2023-06-06
申请号：US16738664
申请日：2020-01-09
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
CPC classification number: C07K14/001 , C12N9/22
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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公开(公告)号：US11661577B2
公开(公告)日：2023-05-30
申请号：US16236248
申请日：2018-12-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： James Q. Boedicker , Rustem F. Ismagilov , Hyun Jung Kim
IPC: C12Q1/18 , G01N33/542 , C12M1/42 , C12N1/38 , C12N11/04 , C12P39/00 , G01N33/543 , C12M1/00 , C12M1/12 , C12M1/14 , C12N1/20
CPC classification number: C12M35/08 , C12M1/14 , C12M23/34 , C12M25/01 , C12N1/20 , C12N1/38 , C12N11/04 , C12P39/00 , C12Q1/18 , G01N33/542 , G01N33/54313
Abstract: Provided herein are devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
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公开(公告)号：US20230158283A1
公开(公告)日：2023-05-25
申请号：US17993743
申请日：2022-11-23
Applicant: California Institute of Technology
Inventor： WEI GAO , EHSAN SHIRZAEI SANI
CPC classification number: A61M35/10 , A61N1/36031 , A61F13/00063 , A61M2230/20 , A61M2205/3584 , A61M2230/201 , A61M2205/0205 , A61M2230/208 , A61F2013/00285
Abstract: Systems and methods for a smart bandage for monitoring and treating wounds are provided herein. The smart bandage may be a smart, wearable, flexible multi-layer substrate that may include a system that can monitor wound characteristics, perform autonomous bioanalysis of wound characteristics to determine wound treatment plans in a non-invasive method, perform drug delivery or antimicrobial agent release to treat and prevent infections, and promote healing by electrical stimulation. The smart bandage may be equipped with a wireless network that can communicate with users, such as patients and medical providers, directly about a patient's wound condition and provide for on-demand wound treatment.
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Patent Agency Ranking
136.发明公开公开(公告)号：US20230158171A1
公开(公告)日：2023-05-25
申请号：US17850879
申请日：2022-06-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Mikhail SHAPIRO , Jerzy O. SZABLOWSKI
CPC classification number: A61K48/0058 , A61P21/00 , C12N15/113 , A61K48/0016 , A61K48/0025 , A61K48/0066 , A61K48/0083 , A61M37/00 , A61N7/00 , A61K38/1709 , A61K9/0019 , A61K48/0075 , A61N2007/003 , A61N2007/0039 , A61N2007/0021
Abstract: Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.
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公开(公告)号：US20230151440A1
公开(公告)日：2023-05-18
申请号：US17810696
申请日：2022-07-05
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12Q1/70 , C12Q1/68 , C12Q1/6851
CPC classification number: C12Q1/701 , C12Q1/703 , C12Q1/68 , C12Q1/6851 , Y10T436/143333
Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US20230150660A1
公开(公告)日：2023-05-18
申请号：US18055757
申请日：2022-11-15
Applicant: California Institute of Technology
Inventor： Alireza Ramezani , Morteza Gharib
CPC classification number: B64C37/00 , B64C39/024 , B64C2201/162
Abstract: In some embodiments, a multi-modal robot can be capable of aerial mobility and ground mobility, and can switch between configuration. The multi-modal robot can include a chassis, and a leg attached to the chassis. The leg can include a frontal hip joint. The frontal hip joint can rotate around a frontal hip axis of rotation. The frontal hip axis of rotation can be parallel to a longitudinal axis of the chassis. The leg can further include a sagittal hip joint, wherein the sagittal hip joint is coupled to the first distal end of a first link. The sagittal hip joint can rotate around a sagittal hip axis of rotation. The leg can include a wheel. The wheel can be configured to rotate around a wheel axis of rotation. The leg can further include a propeller. The propeller can be co-axial with the wheel.
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公开(公告)号：US11649276B2
公开(公告)日：2023-05-16
申请号：US17470184
申请日：2021-09-09
Inventor： Hugo Mouquet , Michel Nussenzweig , Pamela J. Bjorkman , Louise Scharf
CPC classification number: C07K16/1045 , A61K39/42 , C07K16/1063 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C12N2740/16111
Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.
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公开(公告)号：US20230146923A1
公开(公告)日：2023-05-11
申请号：US17982901
申请日：2022-11-08
Applicant: California Institute of Technology
Inventor： Tsui-Fen Chou , Shan Li , Feng Wang , Nadia Houerbi
IPC: C12Q1/6886 , C12N15/113 , C07K16/40 , C12N9/22 , A61P35/00
CPC classification number: C12Q1/6886 , C12N15/1137 , C07K16/40 , C12N9/22 , A61P35/00
Abstract: Provided herein are methods and compositions for inhibiting p97, for the treatment of a cancer in a subject, or a symptom thereof. Upon treatment, the cancer, or a symptom thereof is reduced in the subject. Additionally, methods for measuring sensitivity of a subject to p97 inhibition, methods of assessing a pharmaceutical agent for p97 inhibition activity, and methods of assessing the effect of a pharmaceutical agent for p97 inhibition activity in a subject are provided herein.
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