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    Combination reader
    131.
    发明授权
    Combination reader 有权
    组合阅读器

    公开(公告)号：US06970240B2

    公开(公告)日：2005-11-29

    申请号：US10384995

    申请日：2003-03-10

    Applicant: Mark F. Oldham ,  Howard G. King ,  Douwe D. Haga ,  Tracy L. Ferea

    Inventor： Mark F. Oldham ,  Howard G. King ,  Douwe D. Haga ,  Tracy L. Ferea

    IPC: G01N21/64 ,  G01J3/30

    CPC classification number: G01N21/76 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0634

    Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light illuminates the illumination region. Additionally, the apparatus includes an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal has wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.

    Abstract translation: 一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。 该装置包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。 至少一部分光照射照明区域。 另外，该装置包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。 第一信号具有与照亮照明区域的由LED发射的光的部分的波长有效不同的波长。

    Multispectral imaging system
    132.
    发明申请
    Multispectral imaging system 有权
    多光谱成像系统

    公开(公告)号：US20030223248A1

    公开(公告)日：2003-12-04

    申请号：US10163233

    申请日：2002-06-04

    Inventor： Paul J. Cronin ,  Daniel Orband ,  Stephen D. Fantone ,  Peter J. Miller

    IPC: F21V007/04

    CPC classification number: G01J3/10 ,  G01J3/2823 ,  G01J2003/1282 ,  G01N21/255 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/0635 ,  G01N2201/0638

    Abstract: The invention features a multi-spectral microscopy system for illuminating a sample with light of a selectable spectral content and generating an image of the sample in response to the illumination. The multi-spectral microscopy system includes a multispectral illuminator that provides output radiation having the selectable spectral content. A preferred set of optical arrangements for the multispectral illuminator generates the output radiation so that the spectral content of the output radiation is substantially uniform across its transverse profile. Furthermore, the multispectral illuminator can include monitoring optics and a corresponding detector array that independently monitors the output in each spectral band of the radiation produced by the multispectral illuminator. The monitoring provides calibration, feedback, and/or source aging information to insure robust and reliable performance for the multispectral illuminator. The multi-spectral microscopy system also includes a microscope which illuminates the sample with light derived from the output of the multispectral illuminator, and beam modification optics, which modify the output from the lamp prior to the microscope to increase the light efficiency of the microscope and fully exploit field of view and resolution of the microscope.

    Abstract translation: 本发明的特征在于一种多光谱显微镜系统，用于利用可选光谱含量的光照射样品，并响应于照明产生样品的图像。 多光谱显微镜系统包括多光谱照明器，其提供具有可选光谱含量的输出辐射。 用于多光谱照明器的优选的一组光学装置产生输出辐射，使得输出辐射的光谱含量在其横向轮廓上基本上是均匀的。 此外，多光谱照明器可以包括监视光学器件和相应的检测器阵列，其独立地监视由多光谱照明器产生的辐射的每个光谱带中的输出。 监控提供校准，反馈和/或源老化信息，以确保多光谱照明器的稳健可靠的性能。 多光谱显微镜系统还包括用来自多光谱照明器的输出的光照射样品的显微镜以及在显微镜之前改变来自灯的输出的光束修改光学器件，以提高显微镜的光效率， 充分利用显微镜的视野和分辨率。

    Illuminator optical assembly for an analytical instrument and methods of alignment and manufacture
    133.
    发明授权
    Illuminator optical assembly for an analytical instrument and methods of alignment and manufacture 失效
    用于分析仪器的照明器光学组件和对准和制造方法

    公开(公告)号：US6042249A

    公开(公告)日：2000-03-28

    申请号：US688559

    申请日：1996-07-30

    Applicant: Peter Spangenberg

    Inventor： Peter Spangenberg

    IPC: G01N15/14 ,  F21K7/00

    CPC classification number: G01N15/14 ,  G01N2201/0633

    Abstract: An optical illuminator assembly for an analytical instrument, such as a clinical hematology or a flow cytometer instrument, and method of aligning the components of the illuminator assembly. The illuminator assembly includes a plurality of optical components, such as a laser source, e.g., a laser diode, optionally a spatial filter, a beam shaping aperture, and a focussing lens. The optical components are mounted in mounting plates, frames or mounting cylinders, which are in turn coupled to a mounting surface on the assembly. Each of the mounting plates or frames is movable in the x and y directions, perpendicular to the laser beam, by micrometer adjusters having opposing spring plungers or the like, to decenter components in the desired laser beam path of the illuminator assembly. The micrometers and spring plungers are removably secured in the mounting surface so that after the x-y alignment, the mounting plates or frames can be secured to the mounting surface by, e.g., screws, and the micrometers and spring plungers are removed. The beam focussing lenses are similarly mounted in mounting cylinders and adjusted in the z direction of the beam path (focused) by removably mounted adjusters, such as eccentric focussing tools. After focussing, the focusing tools are removed. Thus, a factory alignment and a low cost prealigned optical illuminator assembly is obtained.

    Abstract translation: 用于分析仪器的光学照明器组件，例如临床血液学或流式细胞仪器，以及对准照明器组件的部件的方法。 照明器组件包括多个光学部件，例如激光源，例如激光二极管，可选地是空间滤光器，光束整形孔和聚焦透镜。 光学部件安装在安装板，框架或安装筒中，安装板又安装在组件上的安装表面上。 每个安装板或框架可以在垂直于激光束的x和y方向上通过具有相对的弹簧柱塞等的微米调节器移动，以便将照射器组件的期望的激光束路径中的部件分解。 微米和弹簧柱塞可移除地固定在安装表面中，使得在x-y对准之后，安装板或框架可以通过例如螺钉固定到安装表面，并且微米和弹簧柱塞被移除。 光束聚焦透镜类似地安装在安装圆筒中并通过可移除地安装的调节器（例如偏心聚焦工具）在光束路径（聚焦）的z方向上调节。 在聚焦之后，去除聚焦工具。 因此，获得了工厂对准和低成本的预对准光学照明器组件。

    Reference laser beam sampling apparatus
    134.
    发明授权
    Reference laser beam sampling apparatus 失效
    参考激光束取样装置

    公开(公告)号：US5844685A

    公开(公告)日：1998-12-01

    申请号：US692933

    申请日：1996-07-30

    Applicant: Richard Gontin

    Inventor： Richard Gontin

    IPC: G01N15/14 ,  G01N21/00

    CPC classification number: G01N15/1436 ,  G01N15/1459 ,  G01N2015/1447 ,  G01N2201/0633

    Abstract: Apparatus for sampling a laser beam used in an analytical instrument, e.g., a clinical hematology or flow cytometer instrument, for measuring absorption by particles suspended in a stream moving through a flow cell. The laser beam is typically passed through a mask, e.g., a beam shaping aperture, to shape the beam. The shaped beam is then passed through a beam splitter, located downstream of the beam shaping aperture, so that one part of the shaped beam strikes the flow cell (e.g., is focused onto the moving stream of particles), and a second part is diverted to obtain a reference measurement of the beam about to strike the flow cell. An absorption measurement is obtained of the light passing through the flow cell, and a difference circuit is used to obtain a difference signal relating the differences between the measured absorption and the unabsorbed reference sample of the initial beam intensity. The laser source may be a laser diode and a spatial filter may be used to produce the laser beam to be passed through the beam shaping aperture.

    Abstract translation: 用于采样分析仪器例如临床血液学或流式细胞仪器的激光束的装置，用于测量悬浮在移动通过流动池的流中的颗粒的吸收。 激光束通常通过掩模，例如光束整形孔，以形成光束。 成形的光束然后通过位于光束成形孔的下游的分束器，使得成形光束的一部分撞击流动池（例如，聚焦在移动的颗粒物流上），并且第二部分被转向 以获得要撞击流动池的梁的参考测量。 获得通过流通池的光的吸收测量，并且使用差分电路来获得与测量的吸收和未吸收的参考样品之间的初始束强度的差异相关的差分信号。 激光源可以是激光二极管，并且可以使用空间滤光器来产生要通过光束整形孔的激光束。

    Sensor device
    137.
    发明授权
    Sensor device 有权

    公开(公告)号：US12055481B2

    公开(公告)日：2024-08-06

    申请号：US17447724

    申请日：2021-09-15

    Applicant: VIAVI Solutions Inc.

    Inventor： Valton Smith ,  William D. Houck ,  Curtis R. Hruska ,  Marc K. Von Gunten

    IPC: G01N21/31 ,  A61B5/026

    CPC classification number: G01N21/31 ,  A61B5/0261 ,  G01N2201/0633 ,  G01N2201/08

    Abstract: A sensor device may determine a first optical sensor value associated with a first displacement and a second optical sensor value associated with a second displacement, wherein the first displacement is between an emitter associated with the first optical sensor value and a sensing location used to determine the first optical sensor value, wherein the second displacement is between an emitter associated with the second optical sensor value and a sensing location used to determine the second optical sensor value, and wherein the first displacement is different from the second displacement. The sensor device may determine one or more measurements using the first optical sensor value and the second optical sensor value, wherein the one or more measurements relate to a first penetration depth associated with the first optical sensor value, and a second penetration depth associated with the second optical sensor value.

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