公开(公告)号：US10772843B2

公开(公告)日：2020-09-15

申请号：US15994079

申请日：2018-05-31

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kathleen Emily-Ann Halasz ,  Yashwant V. Pathak ,  Vijaykumar Bhadabhai Sutariya

IPC: A61K9/51 ,  A61P27/02 ,  A61K9/00 ,  A61K31/573 ,  A61K31/7048 ,  B82Y5/00

Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

公开(公告)号：US20200254082A1

公开(公告)日：2020-08-13

申请号：US16858029

申请日：2020-04-24

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Xingmin Sun ,  Abraham Sonenshein

IPC: A61K39/08 ,  C07K14/33 ,  C12N9/52 ,  C12N9/10

Abstract: Described are non-toxigenic Clostridium difficile strains and spores. Also described are vaccines comprising the Clostridium difficile spores. Further described are methods of preventing or treating a Clostridium difficile infection in a subject in need thereof.

公开(公告)号：US10688080B2

公开(公告)日：2020-06-23

申请号：US16049164

申请日：2018-07-30

Applicant: University of South Florida ,  The Regents of the University of California

Inventor： Yu Chen ,  Nicholas Joseph Torelli ,  Orville Antonio Pemberton ,  Xiujun Zhang ,  Adam Renslo ,  Kyle Defrees ,  Priyadarshini Jaishankar

IPC: A61K31/41 ,  A61K31/55 ,  A61K31/454 ,  A61K31/427 ,  A61K31/4155 ,  A61K45/06 ,  A61P31/04 ,  C07D417/14 ,  C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D257/06

Abstract: The present disclosure provides compositions including a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

公开(公告)号：US10688063B2

公开(公告)日：2020-06-23

申请号：US15730423

申请日：2017-10-11

Applicant: University of South Florida

Inventor： Robert Vito Farese ,  Mini Paliyath Sajan

IPC: A61K31/122 ,  A61P3/04 ,  A61P3/10 ,  A61K31/341

Abstract: Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).

公开(公告)号：US10653750B2

公开(公告)日：2020-05-19

申请号：US15561158

申请日：2016-03-23

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Charles Joseph Lockwood ,  Umit Ali Kayisli ,  Murat Basar ,  Ozlem Guzeloglu-Kayisli ,  Nihan Semerci ,  Frederick Schatz

IPC: A61K38/19 ,  A61K45/06 ,  A61K31/57 ,  A61P15/00 ,  A61K9/00

Abstract: The present invention concerns compositions and methods for inhibition of abnormal uterine bleeding (AUB), such as that associated with use of long-acting progestin-only contraceptives (LAPCs). An aspect of the invention concerns compositions comprising chemokine (C-C motif) ligand 2 (CCL2), or a biologically active fragment thereof, which may administered to subjects for inhibition of AUB. Another aspect of the invention concerns methods for inhibiting AUB, comprising administering an effective amount of CCL2, or a biologically active fragment thereof, to a subject in need thereof. Another aspect of the invention concerns a kit for inhibiting AUB.

公开(公告)号：US10653642B2

公开(公告)日：2020-05-19

申请号：US16293535

申请日：2019-03-05

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Umesh Kumar Jinwal ,  Vetriselvan Manavalan

IPC: A61K9/00 ,  A61P25/28 ,  A61K31/055

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

公开(公告)号：US10646462B2

公开(公告)日：2020-05-12

申请号：US15610668

申请日：2017-06-01

Applicant: University of South Florida

Inventor： Dominic Paul D'Agostino ,  Patrick Arnold ,  Shannon Kesl

IPC: A01N37/02 ,  A01N37/06 ,  A61K31/225 ,  A61K31/23 ,  A61K31/047 ,  A61K31/22 ,  A61K31/19 ,  A61K31/20 ,  A23L2/52

Abstract: Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. Use of these substances does not adversely affect lipid profiles. By initiating rapid ketosis and accelerating the rate of ketoadaptation, this invention is useful for the avoidance of glucose withdrawal symptoms commonly experienced by individuals initiating a ketogenic diet, and minimizes the loss of lean body mass during dietary restriction.

公开(公告)号：US20200071271A1

公开(公告)日：2020-03-05

申请号：US16346039

申请日：2017-10-31

Applicant: University of Kansas ,  University of South Florida

Inventor： Sanket Jaiprakash MISHRA ,  Brian S.J. BLAGG ,  Chad Anthony DICKEY

IPC: C07D207/325 ,  C07D401/06 ,  A61P27/06 ,  A61P35/00

Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

公开(公告)号：US10543221B2

公开(公告)日：2020-01-28

申请号：US16050601

申请日：2018-07-31

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yu Chen ,  Orville Antonio Pemberton ,  Adam Renslo ,  Priyadarshini Jaishankar

IPC: A61K31/675 ,  C07F9/60 ,  C07F9/6561 ,  A61P31/04 ,  A61K31/665 ,  A61K45/06 ,  A61K31/407 ,  C07F9/655

Abstract: Provided herein are heterocyclic compounds and pharmaceutical formulations that can be used to treat bacterial infections. Also provided herein are methods of making and using the heterocyclic compounds and pharmaceutical formulations.

公开(公告)号：US20200022994A1

公开(公告)日：2020-01-23

申请号：US16554187

申请日：2019-08-28

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Mildred Enid ACEVEDO-DUNCAN ,  Wishrawana Sarathi RATNAYAKE ,  David A. OSTROV

IPC: A61K31/675 ,  G01N33/574 ,  C12Q1/6886 ,  A61K31/185 ,  A61K31/122 ,  A61K31/194 ,  A61K31/255 ,  A61K45/06

Abstract: The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ζ and/or PKC-ι. Non-limiting examples of an inhibitor of PKC-ζ and/or PKC-ι include ICA-1 and ACPD. The invention also provides PKC-ζ and/or PKC-ι as biomarkers for identifying a melanoma in a subject as likely to be responsive or non-responsive to a therapy using an inhibitor of PKC-ζ and/or PKC-ι. Accordingly, a method of identifying a subject having a melanoma as being responsive or non-responsive to a melanoma therapy with an inhibitor of PKC-ζ and/or PKC-ι based on the levels and/or activity of PKC-ζ and/or PKC-ι mRNA or protein in the melanoma cells from the subject are also provided.