公开(公告)号：US08451452B2

公开(公告)日：2013-05-28

申请号：US12764510

申请日：2010-04-21

Applicant: Adrian Podoleanu ,  Simon Tuohy

Inventor： Adrian Podoleanu ,  Simon Tuohy

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02004 ,  A61B3/1015 ,  A61B3/102 ,  A61B3/156 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02038 ,  G01B9/02063 ,  G01B9/02068 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70

Abstract: Methods and devices are disclosed for acquiring depth resolved aberration information using principles of low coherence interferometry and perform coherence gated wavefront sensing (CG-WFS). The wavefront aberrations is collected using spectral domain low coherence interferometry (SD-LCI) or time domain low coherence interferometry (TD-LCI) principles. When using SD-LCI, chromatic aberrations can also be evaluated. Methods and devices are disclosed in using a wavefront corrector to compensate for the aberration information provided by CG-WFS, in a combined imaging system, that can use one or more channels from the class of (i) optical coherence tomography (OCT), (ii) scanning laser ophthalmoscopy, (iii) microscopy, such as confocal or phase microscopy, (iv) multiphoton microscopy, such as harmonic generation and multiphoton absorption. For some implementations, simultaneous and dynamic aberration measurements/correction with the imaging process is achieved. The methods and devices disclosed can provide wavefront sensing in the presence of stray reflections from optical interfaces.

Abstract translation: 公开了使用低相干干涉测量原理获取深度分辨像差信息并执行相干门控波前检测（CG-WFS）的方法和装置。 使用频域低相干干涉测量（SD-LCI）或时域低相干干涉测量（TD-LCI）原理收集波前像差。 当使用SD-LCI时，也可以评估色差。 在使用波前校正器来补偿在组合成像系统中由CG-WFS提供的像差信息的方法和装置被公开，该组合成像系统可以使用来自（i）光学相干断层扫描（OCT）的一个或多个通道， ii）扫描激光眼底镜检查，（iii）显微镜，如共焦或相位显微镜，（iv）多光子显微镜，如谐波产生和多光子吸收。 对于一些实施方案，实现了通过成像过程的同步和动态像差测量/校正。 所公开的方法和装置可以在存在来自光学接口的杂散反射的情况下提供波前感测。

公开(公告)号：US20130100406A1

公开(公告)日：2013-04-25

申请号：US13686214

申请日：2012-11-27

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower

IPC: A61B3/10 ,  G01B9/02

CPC classification number: A61B3/102 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

公开(公告)号：US08405836B2

公开(公告)日：2013-03-26

申请号：US12728147

申请日：2010-03-19

Applicant: Andrew D. Yablon

Inventor： Andrew D. Yablon

IPC: G01N21/41

CPC classification number: G01N21/412 ,  G01B9/02007 ,  G01B9/0201 ,  G01B9/02024 ,  G01B9/02084 ,  G01B9/0209 ,  G01B11/02 ,  G01D5/266 ,  G01M11/331 ,  G01N21/45 ,  G02B6/02

Abstract: Subject matter disclosed herein relates to measuring optical fibers or measuring devices comprising optical fibers and, in particular, to measuring a variation of refractive index of an optical fiber as a function of position and wavelength.

Abstract translation: 本文公开的主题涉及测量包括光纤的光纤或测量装置，特别是测量作为位置和波长的函数的光纤的折射率的变化。

公开(公告)号：US20120182560A1

公开(公告)日：2012-07-19

申请号：US13351444

申请日：2012-01-17

Applicant: Grigory Valentinovich Gelikonov ,  Valentin Mikhailovich Gelikonov ,  Pavel Andreevich Shilyagin

Inventor： Grigory Valentinovich Gelikonov ,  Valentin Mikhailovich Gelikonov ,  Pavel Andreevich Shilyagin

IPC: G01N21/55

CPC classification number: G01B9/02044 ,  G01B9/0201 ,  G01B9/0209

Abstract: The invention relates to optical low-coherence reflectometry with spectral reception and may be used for obtaining images without coherent noise caused by self-interference of the radiation scattered from the studied object and by spurious reflections in the optical path of the system. Two or more consecutive measurements of the interference spectrum are made. During at least one measurement of the interference spectrum by means of the interference control unit the phase between the interfering parts of the radiation is modulated by a certain law during exposure, which results in averaging and, hence, zeroing of the cross-correlation (useful) component of the registered spectrum, and during at least one additional measurement of the interference spectrum, the phase between the interfering parts of the radiation is not modulated during exposure. The phase between the interfering parts of the radiation may be set to be different in additional measurements of the interference spectrum. The invention allows coherent noise to be fully eliminated without loss of the radiation power scattered by the object.

Abstract translation: 本发明涉及具有光谱接收的光学低相干反射测量，并且可以用于获得没有由被研究物体散射的辐射的自干扰和系统光路中的假反射引起的相干噪声的图像。 进行两个或多个连续的干涉光谱测量。 在通过干扰控制单元对干扰谱的至少一次测量期间，辐射的干扰部分之间的相位在曝光期间被一定的规律调制，这导致互相关的平均化和因此的归零（有用的 ）分量，并且在干扰光谱的至少一次附加测量期间，辐射的干扰部分之间的相位在曝光期间不被调制。 辐射的干扰部分之间的相位可以被设置为在附加的干涉光谱测量中是不同的。 本发明允许完全消除相干噪声，而不损失被物体散射的辐射功率。

公开(公告)号：US07978338B2

公开(公告)日：2011-07-12

申请号：US12541325

申请日：2009-08-14

Applicant: Peter De Groot ,  Mark Davidson ,  Jan Liesener ,  Xavier Colonna De Lega ,  Leslie L. Deck

Inventor： Peter De Groot ,  Mark Davidson ,  Jan Liesener ,  Xavier Colonna De Lega ,  Leslie L. Deck

IPC: G01B11/02

CPC classification number: G01B9/0209 ,  G01B9/02007 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02039 ,  G01B9/02057 ,  G01B9/02068 ,  G01B9/02077 ,  G01B11/2441 ,  G01B2290/45 ,  G01B2290/70 ,  Y10T29/49002

Abstract: Interferometry system are disclosed that include a detector sub-system including a monitor detector, interferometer optics for combining test light from a test object with primary reference light from a first reference interface and secondary reference light from a second reference interface to form a monitor interference pattern on a monitor detector, wherein the first and second reference interfaces are mechanically fixed with respect to each other and the test light, a scanning stage configured to scan an optical path difference (OPD) between the test light and the primary and secondary reference light to the monitor detector while the detector sub-system records the monitor interference pattern for each of a series of OPD increments, and an electronic processor electronically coupled to the detector sub-system and the scanning stage, the electronic processor being configured to determine information about the OPD increments based on the detected monitor interference pattern.

Abstract translation: 公开了一种干涉测量系统，其包括检测器子系统，该检测器子系统包括监视器检测器，用于将来自测试对象的测试光与来自第一参考接口的主要参考光组合的来自第二参考接口的第二参考光组合的干涉仪光学元件，以形成监视器干涉图案 在监视器检测器上，其中所述第一参考接口和所述第二参考接口相对于彼此和所述测试光机械地固定;扫描台，被配置为扫描所述测试光和所述主参考光与所述次参考光之间的光程差（OPD） 监视器检测器，同时检测器子系统记录用于一系列OPD增量中的每一个的监视器干涉图案，以及电子处理器，电子耦合到检测器子系统和扫描级，电子处理器被配置为确定关于 OPD根据检测到的监视器干扰模式递增。

公开(公告)号：US07978316B2

公开(公告)日：2011-07-12

申请号：US12463727

申请日：2009-05-11

Applicant: Avraham Aharoni

Inventor： Avraham Aharoni

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  G01B9/0201 ,  G01B9/02076 ,  G01B2290/70 ,  G01H9/00

Abstract: An optical perturbation sensing system includes a probing beam incident on a medium with perturbations and a sensing beam redirected from the medium and incident on a surface area of a photodetector. A reference beam directed onto the photodetector surface forms, with the sensing beam, an interference pattern on the photodetector surface and a phase patterner with at least two phase regions across its section, generates different phases in different regions of the interference pattern. An array of photodetector elements detects each phase region of the interference pattern and a constructive combiner subtract pairs of the detected signals, squares the subtracted signal squares, and sums the squared signals to form a stronger detected signal with reduced intensity noise, reduced background noise, and reduced sensitivity to phase drifts.

Abstract translation: 光学扰动感测系统包括入射在具有扰动的介质上的探测光束和从介质重新定向并入射到光电检测器的表面区域上的感测光束。 指向光电检测器表面的参考光束与感测光束形成在光电检测器表面上的干涉图案，并且在其部分上具有至少两个相位区域的相位图案，在干涉图案的不同区域中产生不同的相位。 光检测器元件的阵列检测干涉图案的每个相位区域，并且建构性组合器减去检测信号的对，对减法信号平方进行平方，并且将平方信号相加以形成具有降低的强度噪声，降低的背景噪声的更强的检测信号， 并降低对相位漂移的敏感性。

公开(公告)号：US07948637B2

公开(公告)日：2011-05-24

申请号：US12408121

申请日：2009-03-20

Applicant: Peter De Groot

Inventor： Peter De Groot

IPC: G01B9/02

CPC classification number: G01B9/02057 ,  G01B9/02004 ,  G01B9/0201 ,  G01B9/02059 ,  G01B9/02069 ,  G01B9/02083 ,  G01B2290/35

Abstract: In certain aspects, disclosed methods include combining reference light reflected from a reference surface with test light reflected from a test surface to form combined light, the test and reference light being derived from a common source, sinusoidally varying a phase between the test light and reference light, where the sinusoidal phase variation has an amplitude u, recording at least one interference signal related to changes in an intensity of the combined light in response to the sinusoidal variation of the phase, determining information related to the phase using a phase shifting algorithm that has a sensitivity that varies as a function of the sinusoidal phase shift amplitude, where the sensitivity of the algorithm at 2 u is 10% or less of the sensitivity of the algorithm at u.

Abstract translation: 在某些方面，所公开的方法包括将从参考表面反射的参考光与从测试表面反射的测试光组合以形成组合光，测试和参考光源自公共源，正弦变化测试光与参考光之间的相位 光，其中正弦相位变化具有振幅u，响应于相位的正弦变化记录与组合光的强度变化相关的至少一个干扰信号，使用相移算法确定与相位相关的信息，该相移算法 具有作为正弦相移幅度的函数的灵敏度，其中算法在2u处的灵敏度为u的算法的灵敏度的10％以下。

公开(公告)号：US20110063616A1

公开(公告)日：2011-03-17

申请号：US12947823

申请日：2010-11-16

Applicant: Feiling Wang

Inventor： Feiling Wang

IPC: G01J4/00

CPC classification number: G01N21/55 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B2562/0242 ,  G01B9/0201 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/40 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/42 ,  G01N21/21 ,  G01N21/27 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/4709 ,  G01N2021/4792 ,  G02B21/06

Abstract: This application describes designs, implementations, and techniques for controlling propagation mode or modes of light in a common optical path, which may include one or more waveguides, to sense a sample.

Abstract translation: 该应用描述了用于控制公共光路中的传播模式或光模式的设计，实现和技术，其可以包括一个或多个波导以感测样本。

公开(公告)号：US20100231917A1

公开(公告)日：2010-09-16

申请号：US12775782

申请日：2010-05-07

Applicant: Joseph A. Izatt ,  Eric L. Buckland ,  David J. Hamo

Inventor： Joseph A. Izatt ,  Eric L. Buckland ,  David J. Hamo

IPC: G01J3/45

CPC classification number: G01B9/0201 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7203 ,  A61B5/7257 ,  G01B9/02011 ,  G01B9/02044 ,  G01B9/02078 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

Abstract: Methods, fourier domain optical coherence tomography (FDOCT) interferometers and computer program products are provided for removing undesired artifacts in FDOCT systems using continuous phase modulation. A variable phase delay is introduced between a reference arm and a sample arm of an FDOCT interferometer using continuous phase modulation. Two or more spectral interferograms having different phase delay integration times are generated. The spectral interferograms are combined using signal processing to remove the undesired artifacts. Systems and methods for switching between stepped and continuous phase shifting Fourier domain optical coherence tomography (FDOCT) and polarization-sensitive optical coherence tomography (PSOCT) are also provided herein.

Abstract translation: 方法提供了傅立叶变换光学相干断层扫描（FDOCT）干涉仪和计算机程序产品，用于消除使用连续相位调制的FDOCT系统中的不期望的伪影。 在使用连续相位调制的FDOCT干涉仪的参考臂和样品臂之间引入可变相位延迟。 产生具有不同相位延迟积分时间的两个或更多个光谱干涉图。 使用信号处理来组合光谱干涉图以去除不想要的伪像。 本文还提供了阶梯式和连续相移傅立叶域光学相干断层扫描（FDOCT）与偏振光敏光学相干断层扫描（PSOCT）之间切换的系统和方法。

公开(公告)号：US20100171960A1

公开(公告)日：2010-07-08

申请号：US12350118

申请日：2009-01-07

Applicant: SHIH-CHU HUANG

Inventor： SHIH-CHU HUANG

IPC: G01B9/02

CPC classification number: G01B9/02083 ,  G01B9/0201

Abstract: Path imbalance measurement of the two arms fiber optic interferometer includes employing a current carrier signal to modulate the semiconductor laser light source of the interferometer to let it output interference signals to generate a carrier phase signal through path imbalance of the interferometer. Then, the interference signals are expanded to be the harmonic components of carrier phase signal frequency by Bessel function. Subsequently, we use the specific relation between the second and the fourth harmonic components of the interference signals to develop the theory of path imbalance measurement. The method mentioned above can measure a few decimeters of path imbalance and its accuracy can reach to a millimeter.

Abstract translation: 双臂光纤干涉仪的路径不平衡测量包括采用当前载波信号来调制干涉仪的半导体激光光源，使其输出干涉信号，以通过干涉仪的路径不平衡产生载波相位信号。 然后，通过贝塞尔函数将干扰信号扩展为载波相位信号频率的谐波分量。 随后，我们使用干扰信号的第二和第四谐波分量之间的具体关系来开发路径不平衡测量的理论。 上述方法可以测量几分之一的路径不平衡，其精度可达到一毫米。