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公开(公告)号：US20210164838A1
公开(公告)日：2021-06-03
申请号：US16759169
申请日：2017-11-07
Applicant: Shimadzu Corporation
Inventor： Hiroshi OTA
Abstract: An accessory for an infrared spectrophotometer is provided in which both an infrared spectrum and a Raman spectrum at the same measurement position of a sample can be easily acquired. By incorporating an infrared optical system and an excitation light source into the accessory for an infrared spectrophotometer, infrared light from an infrared light source of the infrared spectrophotometer and excitation light from the excitation light source provided for the accessory are guided to the same measurement position P in the sample S. A total reflection spectrum is acquired by detecting the totally reflected light from the sample S irradiated with the infrared light by an infrared detector of the infrared spectrophotometer. Raman scattered light from the sample S irradiated with the excitation light is detected by a Raman detector provided in the accessory. By incorporating the accessory into the infrared spectrophotometer and measuring the sample S, both the infrared spectrum (total reflection spectrum) and the Raman spectrum at the same measurement position P of the sample S can be easily acquired.
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公开(公告)号：US20210164835A1
公开(公告)日：2021-06-03
申请号：US17105946
申请日：2020-11-27
Applicant: SKINASSAY Inc.
Inventor： Seong Ho CHO , Gajendra Pratap SINGH
Abstract: A hard apertureless spectrometer includes a housing, a collimator configured to collimate light provided from a soft aperture of a target, a diffraction grating configured to spectroscopically analyze the collimated light, a condenser configured to condense the spectroscopically analyzed light, and a photodetector configured to receive the condensed light output from the condenser and detect a target characteristic.
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153.发明申请公开(公告)号：US20210156794A1
公开(公告)日：2021-05-27
申请号：US17103687
申请日：2020-11-24
Inventor： Taek Jeong , Han Seb Moon , Dai Hyuk Yu , Jae Hoon Lee , Hyun Gue Hong
Abstract: A method is disclosed for increasing an intensity of a signal detected in a spectroscopy device using a vapor cell and a spectroscopy device using the same. An operation method of the spectroscopy device may include: causing a first light for exciting an atom trapped in a vapor cell in a first hyperfine ground state to a first excited state to be incident on the vapor cell; causing a second light for exciting an atom trapped in the vapor cell in a second hyperfine ground state to a second excited state to be incident on the vapor cell; causing a third light for exciting the atom in the second excited state to a third excited state to be incident on the vapor cell; and detecting fluorescence which is emitted while the atom in the third excited state returns to the ground state.
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公开(公告)号：US20210140891A1
公开(公告)日：2021-05-13
申请号：US16771987
申请日：2018-12-12
Applicant: HORIBA, LTD.
Inventor： Yoshito OKUNO , Daisuke IRIKURA , Sakiko AKAJI , Shiro MIYAKE
Abstract: In a method of determining the type of each cell contained in a sample, one Raman spectrum is acquired from one undetermined cell, a plurality of degrees of matching of a Raman spectrum of the undetermined cell with respect to spectra of a plurality of principal components obtained by principal component analysis of a plurality of Raman spectra that are obtained one by one from each of a plurality of known types of cells are calculated, and a type of the undetermined cell is determined by classifying the plurality of degrees of matching based on a result obtained by classifying a plurality of principal component scores corresponding to each of the plurality of known types of cells obtained by the principal component analysis depending on the type of cells by a learning model using supervised learning.
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公开(公告)号：US20210131797A1
公开(公告)日：2021-05-06
申请号：US17146192
申请日：2021-01-11
Applicant: The Boeing Company , FemtoMetrix, Inc.
Inventor： Jeffrey H. Hunt , Jianing Shi , John Paul Changala
Abstract: Surface sensing methods for imaging a scanned surface of a sample via sum-frequency vibrational spectroscopy are disclosed herein. The methods include exposing a sampled location of the scanned surface to a visible light beam and exposing the sampled location to a tunable infrared beam such that the tunable infrared beam is at least partially coincident with the visible light beam. The methods also include varying a frequency of the tunable infrared beam an inducing optical resonance within an imaged structure that extends at least partially within the sampled location. The methods further include receiving at least a portion of an emitted light beam from the sampled location and scanning the visible light beam and the runnable infrared beam across the scanned portion of the scanned surface. The methods also include generating an image of the scanned portion of the scanned surface based upon the receiving and the scanning.
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Patent Agency Ranking
公开(公告)号：US10989662B2
公开(公告)日：2021-04-27
申请号：US16368732
申请日：2019-03-28
Applicant: Azure Biosystems, Inc.
Inventor： Diping Che , Zhefu Zhang
Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
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157.发明授权公开(公告)号：US10989591B2
公开(公告)日：2021-04-27
申请号：US16785123
申请日：2020-02-07
Applicant: University of Maryland, College Park
Inventor： Giuliano Scarcelli , Eitan Edrei
Abstract: An optical system has an illumination optical assembly, a detection optical assembly, a wavefront shaping device, and a controller. The illumination optical assembly focuses interrogating optical radiation to a focal point on or in a sample. The interrogating optical radiation propagates to the focal point along a first optical axis. The detection optical assembly direct optical radiation emanating from the focal point to a detector. The emanating optical radiation propagates from the focal point along a second optical axis. The wavefront shaping device is disposed in an optical path of the interrogating optical radiation or in an optical path of the emanating optical radiation. The controller sets a configuration of the wavefront shaping device to correct for aberration. The first optical axis is at a non-zero angle with respect to the second optical axis.
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公开(公告)号：US20210116298A1
公开(公告)日：2021-04-22
申请号：US16853811
申请日：2020-04-21
Applicant: Massachusetts Institute of Technology
Inventor： Amir H. Atabaki , Rajeev J. RAM , William F. Herrington
Abstract: In swept source Raman (SSR) spectroscopy, a swept laser beam illuminates a sample, which inelastically scatters some of the incident light. This inelastically scattered light is shifted in wavelength by an amount called the Raman shift. The Raman-shifted light can be measured with a fixed spectrally selective filter and a detector. The Raman spectrum can be obtained by sweeping the wavelength of the excitation source and, therefore, the Raman shift. The resolution of the Raman spectrum is determined by the filter bandwidth and the frequency resolution of the swept source. An SSR spectrometer can be smaller, more sensitive, and less expensive than a conventional Raman spectrometer because it uses a tunable laser and a fixed filter instead of free-space propagation for spectral separation. Its sensitivity depends on the size of the collection optics. And it can use a nonlinearly swept laser beam thanks to a wavemeter that measures the beam's absolute wavelength during Raman spectrum acquisition.
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公开(公告)号：US10985082B2
公开(公告)日：2021-04-20
申请号：US17007614
申请日：2020-08-31
Applicant: Akash Systems, Inc.
Inventor： Tyrone D. Mitchell, Jr. , Felix Ejeckam , Daniel Francis , Paul Saunier , Kris Kong
IPC: H04B10/50 , H04B7/185 , H01L27/06 , H01L23/373 , H04W52/52 , H04B1/02 , H04B1/06 , H04B10/564 , G01J3/44 , H04B1/04 , B64G1/10
Abstract: Aspects of wireless communication are described, including a radiofrequency (RF) amplifier chip, configured for transmitting or receiving data, comprising a first substrate comprising a first material and a second substrate comprising a second material that is different from the first material. The first substrate and the second substrate may be lattice-matched such that an interface region between the first substrate and the second substrate exhibits an sp3 carbon peak at about 1332 cm·1 having a full width half maximum of no more than 5.0 cm·1 as measured by Raman spectroscopy. In some aspects, the first substrate and said second substrate permit said chip to transmit or receive data at a transfer rate of at least 500 megabits per second and a frequency of at least 8 GHz. In some aspects, the RF amplifier chip is part of a satellite transmitter.
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公开(公告)号：US10983060B2
公开(公告)日：2021-04-20
申请号：US16382791
申请日：2019-04-12
Applicant: Cedars-Sinai Medical Center
Inventor： Pramod Butte , Paul Lapchak , David Scott Kittle
IPC: G01J1/58 , G01N21/64 , A61B5/00 , G01J3/28 , G01J3/44 , G01J3/02 , A61B5/1455 , A61B5/1459
Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
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