公开(公告)号：US11327017B2

公开(公告)日：2022-05-10

申请号：US17062191

申请日：2020-10-02

Applicant: Verily Life Sciences LLC

Inventor： Supriyo Sinha ,  Charles Santori ,  Andrew Conrad

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/44

Abstract: High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

公开(公告)号：US11280730B2

公开(公告)日：2022-03-22

申请号：US17285961

申请日：2019-08-05

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Marek Höhse ,  Christian Grimm ,  Thomas Regen

IPC: G01J3/00 ,  G01N21/51 ,  G01N21/55 ,  G01J3/44 ,  G01N21/03 ,  G01J3/14

Abstract: The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).

公开(公告)号：US11231328B2

公开(公告)日：2022-01-25

申请号：US16753357

申请日：2018-10-05

Applicant: FEMTO EASY

Inventor： Antoine Dubrouil

IPC: G01J11/00 ,  G01J3/02 ,  G01J3/14 ,  G01J3/28

Abstract: An optical analysis method and assembly for analysing an ultrashort laser pulse, the assembly includes a single-shot optical autocorrelator, having a polarity separator for angular separation of an incident laser radiation beam with fundamental frequency (ω) into two laser radiation beams with the fundamental frequency and linear polarities which are orthogonal to one another, the two beams forming angle therebetween so that the beams at least partially overlap at the output of the separator, a type-II nonlinear crystal receives the at least partially overlapping beams and generates, at the output of the crystal, a single laser radiation beam with harmonic frequency (2ω). A spectral filtering device selectively allows the passage of the single laser radiation beam while blocking the laser radiation beams with fundamental frequency. The non-linear crystal, spectral filtering device, and detection system detect an intensimetric single-shot autocorrelation trace of the order of two at the harmonic frequency.

公开(公告)号：US11226234B2

公开(公告)日：2022-01-18

申请号：US16749168

申请日：2020-01-22

Applicant: Applied Materials, Inc.

Inventor： Guoheng Zhao ,  Edward W. Budiarto ,  Todd J. Egan

IPC: G01J3/28 ,  G01J3/14 ,  G02B6/293 ,  G01J3/02

Abstract: Implementations disclosed describe a system comprising a first optical device to receive an input beam of light, the input beam having a plurality of spectral components of light, and cause the input beam to disperse into a plurality of spectral beams, wherein each of the plurality of spectral beams corresponds to one of the plurality of spectral components and propagates along a spatial path that is different from spatial paths of other spectral beams, and a second optical device to collect a portion of each of the spectral beams, wherein the collected portion depends on the spatial path of the respective spectral beam, and form an output beam of light from the collected portion of each of the spectral beams, wherein a spectral profile of the output beam is different from a spectral profile of the input beam of light.

公开(公告)号：US20220003659A1

公开(公告)日：2022-01-06

申请号：US17375988

申请日：2021-07-14

Applicant: Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase ,  Wenbin Jiang

Inventor： Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase ,  Wenbin Jiang

IPC: G01N15/14 ,  G01N21/53 ,  G01N21/64 ,  G01J3/44 ,  G01J3/18 ,  G01J3/14 ,  G01J3/02 ,  G01J3/28 ,  G01J3/36

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a compact light detection module including a first image array having a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side.

公开(公告)号：US11209349B2

公开(公告)日：2021-12-28

申请号：US16487869

申请日：2018-02-22

Applicant: Pietro Fiorentini (USA), Inc.

Inventor： David Dalby ,  Gordon Lamb ,  Michael Hazell ,  Paul Ryder ,  Robert Jones ,  Margaret Waid ,  Michael Yuratich

IPC: G01N21/64 ,  G01N21/27 ,  G01N33/28 ,  E21B49/08 ,  E21B49/10 ,  G01J3/10 ,  G01J3/14 ,  G01J3/12 ,  G01N21/17 ,  G01N21/552 ,  G01N21/43 ,  G01J3/02

Abstract: Apparatus and methods for performing optical analyses in a harsh environment are disclosed. Some of the systems and methods of the present disclosure include fluorescence, absorption, and reflectance detection using a drum spectrometer. Other systems and methods of the present disclosure include a measurement channel and a parallel reference channel concurrently filtering optical signals.

公开(公告)号：US11175184B2

公开(公告)日：2021-11-16

申请号：US16615919

申请日：2018-05-23

Applicant: SWIMC LLC

Inventor： Hendrika T. J. Supèr ,  Klaas H. De Haas

IPC: G01J3/50 ,  B05D5/06 ,  G01J3/10 ,  G01J3/14 ,  G01J3/18 ,  G01N21/25

Abstract: The color strength of a colored batch containing effect pigments can be measured and corrected using one or more non-uniformly weighted factors to determine, at a plurality of combinations of illumination angles and measurement angles, and at one or more wavelengths, the color and intensity of light reflected or absorbed by a coating film made from the batch in comparison to a reference color strength. Based on such comparison, let-downs or batches may be passed, rejected, mixed or otherwise dispersed. The composition of such let-downs or batches may also or instead be adjusted by adding non-effect pigments, effect pigments, binder, carrier, binder, or non-effect or effect pigments dispersed in either or both of a carrier and binder, in order to correct the let-down or batch color strength to within a desired tolerance of the reference color strength.

公开(公告)号：US11125939B1

公开(公告)日：2021-09-21

申请号：US17224105

申请日：2021-04-06

Applicant: GeneSense Technology Inc.

Inventor： Bingzhou Hong ,  Xianchao Wang ,  Haochen Cui ,  Tianshu Wang ,  Yinghua Sun ,  Mei Yan

IPC: G01J3/14 ,  G02B6/10 ,  G01J3/12

Abstract: A waveguide filter sensing unit is provided. The waveguide sensing unit includes an input waveguide for receiving an optical signal and an interference waveguide region for filtering the optical signal to remove noise therein. The waveguide sensing unit further includes a cladding layer wrapping around the input waveguide and the interference waveguide region; and an optical signal detector converting the filtered optical signal into an electrical signal. The width of the input waveguide is smaller than that of the interference waveguide region, and the refractive index of the cladding layer is smaller than that of the input waveguide and the interference waveguide region.

公开(公告)号：US20210256931A1

公开(公告)日：2021-08-19

申请号：US17242897

申请日：2021-04-28

Applicant: Dennis Willard Davis ,  Alice McKinstry Davis

Inventor： Dennis Willard Davis ,  Alice McKinstry Davis

IPC: G09G5/02 ,  G09G5/10 ,  G01J3/46 ,  G01J3/42 ,  G01J3/18 ,  G01J3/14 ,  G02B27/10 ,  G02B27/12 ,  G02B27/28

Abstract: Disclosed is a method and system for cost effective, convenient remote color reproduction and matching that can be used to convey color to observers remote to the physical source of color. Such remote observers can include product consumers wishing to view a product color, for example. In a preferred embodiment, the method comprises capture of article or product reflectance spectra and the use of this spectrum to filter ambient light or directed light in the environment of a remote user. Other embodiments of methods include various techniques to capture product spectral information and color matching functions useful for color reproduction using colored light sources. Additional systems embodiments include devices exploiting multiprimary displays to render the product color in avoidance of metamerism.

公开(公告)号：US11035729B1

公开(公告)日：2021-06-15

申请号：US16602088

申请日：2019-08-05

Applicant: J.A. WOOLLAM CO., INC

Inventor： Jeremy A. Van Derslice ,  Martin M. Liphardt

IPC: G01J3/447 ,  G01B9/02 ,  G01N21/21 ,  G01J3/14

Abstract: Reflectometer, spectrophotometer, ellipsometer, and polarimeter systems having a supercontinuum laser source of coherent electromagnetic radiation over a range of about 400-about 2500 nm, a stage for supporting a sample and a detector of electromagnetic radiation, wherein the supercontinuum source provides a coherent beam of electromagnetic radiation which interacts with a sample, and the detector system comprises functional combinations of gratings and/or combination dichroic beam splitter-prisms, which themselves can be optimized as regards wavelength dispersion characteristics, directs wavelengths in various ranges to various detectors that are well suited to detect them.