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    METHODS OF DIAGNOSING BRAIN INJURY
    11.
    发明公开
    METHODS OF DIAGNOSING BRAIN INJURY 审中-公开

    公开(公告)号：US20230295684A1

    公开(公告)日：2023-09-21

    申请号：US18147360

    申请日：2022-12-28

    Applicant: Abbott Laboratories

    Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

    IPC: C12Q1/44 ,  G01N33/68 ,  A61B5/00

    CPC classification number: C12Q1/44 ,  A61B5/4064 ,  G01N33/68 ,  G01N2800/40

    Abstract: Disclosed herein are methods and systems of determining whether a subject’s levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).

    BOVINE MILK EXOSOME PRODUCTS AND METHODS, NUTRITIONAL COMPOSITIONS, AND THERAPEUTIC METHODS
    14.
    发明公开
    BOVINE MILK EXOSOME PRODUCTS AND METHODS, NUTRITIONAL COMPOSITIONS, AND THERAPEUTIC METHODS 审中-公开

    公开(公告)号：US20230263178A1

    公开(公告)日：2023-08-24

    申请号：US17907750

    申请日：2021-04-01

    Applicant: Abbott Laboratories

    Inventor： José María LÓPEZ PEDROSA ,  Ricardo RUEDA CABRERA ,  Jorge GARCÍA MARTÍNEZ

    IPC: A23C9/142 ,  A23L33/00 ,  A61P3/10 ,  A61K35/20

    CPC classification number: A23C9/1425 ,  A23L33/40 ,  A61P3/10 ,  A61K35/20

    Abstract: A method of obtaining an exosome-enriched product comprises providing a whey-containing bovine milk fraction, conducting a first centrifugation of the whey-containing bovine milk fraction to obtain a whey middle fraction, conducting a second centrifugation of the whey middle fraction at an increased speed to obtain a concentrated whey fraction, filtering the concentrated whey fraction to obtain a filtered whey fraction, and conducting a third centrifugation of the filtered whey fraction at a further increased speed to obtain an exosome-enriched product. The exosome-enriched product comprises intact exosomes and less than 5 wt % casein based on the total weight of protein in the exosome-enriched product. Nutritional compositions comprise protein, carbohydrate, and/or fat, and exosomes provided by addition of the exosome-enriched product. A method of improving insulin sensitivity in a subject comprises administering a nutritional composition comprising the exosome-enriched product.

    Spatially resolved ligand-receptor binding assays
    16.
    发明授权
    Spatially resolved ligand-receptor binding assays 有权

    公开(公告)号：US11719641B2

    公开(公告)日：2023-08-08

    申请号：US17711375

    申请日：2022-04-01

    Applicant: Abbott Laboratories

    Inventor： Qiaoqiao Ruan ,  Sylvia C. Saldana ,  Joseph P. Skinner ,  Sergey Y. Tetin

    IPC: G01N21/64 ,  G01N33/543

    CPC classification number: G01N21/6456 ,  G01N33/543

    Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of:



    (a) providing the results of a ligand-receptor binding assay; and
    (b) qualifying the results of a ligand-receptor binding assay.




    More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.

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