公开(公告)号：US20160022628A1

公开(公告)日：2016-01-28

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/375 ,  A23L1/302 ,  A61K31/202 ,  A23L1/29 ,  A23L1/30

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

Abstract translation: 本发明涉及通过施用天然生育酚的混合物来改善婴儿的CNS成熟的方法，其中所述组合物含有类似于在人母乳中发现的最适生育酚谱，并且可以包括从早期到过渡到 成熟的人类母乳。 为了易于施用和最大化效力，天然生育酚的优化混合物通常以具有有限水平的非RRRα-生育酚的口服剂型递送，以使RRRα-生育酚对刺激出生后CNS发育的功效最大化。

公开(公告)号：US20150374024A1

公开(公告)日：2015-12-31

申请号：US14770876

申请日：2014-03-12

Applicant: ABBOTT LABORATORIES

Inventor： Douglas Wearly ,  Eik-Lang Lau ,  Terrence Mazer ,  Normanella Dewille ,  Gary Katz ,  Wendy Fox

IPC: A23L3/18 ,  A23L3/015 ,  A23P1/12 ,  A23L3/3571

CPC classification number: A23L3/18 ,  A23L3/015 ,  A23L3/3571 ,  A23P30/20 ,  A23V2002/00 ,  A23V2300/16

Abstract: A method of reducing a pathogenic microorganism population in a powdered nutritional food composition is described herein. The powdered nutritional food composition includes a fat, a protein, and a carbohydrate. The method includes forming an emulsion of the powdered nutritional food composition and extruding the emulsified powdered nutritional food composition at a temperature of less than about 100° C. The method produces at least a 5 log reduction in the pathogenic microorganism population in the extruded powdered nutritional food composition. The extruded powdered nutritional food composition has a water activity level of about 0.3 to about 0.95.

Abstract translation: 本文描述了在粉末状营养食品组合物中降低致病微生物群体的方法。 粉状营养食品组合物包括脂肪，蛋白质和碳水化合物。 该方法包括形成粉状营养食品组合物的乳液并在小于约100℃的温度下挤出乳化的粉状营养食品组合物。该方法在挤出的粉状营养物中产生至少5log的病原微生物群体减少量 食物成分。 挤出的粉状营养食品组合物的水活度水平为约0.3至约0.95。

公开(公告)号：US20230270151A1

公开(公告)日：2023-08-31

申请号：US18056768

申请日：2022-11-18

Applicant: Abbott Laboratories

Inventor： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC: A23L33/115 ,  A23L33/00 ,  A23L33/15 ,  A23C9/152 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19

CPC classification number: A23L33/115 ,  A23L33/40 ,  A23L33/15 ,  A23C9/1528 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19 ,  A23C9/1526 ,  A23V2002/00

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US20160022710A1

公开(公告)日：2016-01-28

申请号：US14774745

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Tama Bloch ,  Christina Sherry ,  Maria Ramirez Gonzalez ,  Matthew Kuchan ,  Gary Katz ,  Elena Oliveros Delgado ,  Angela Santos

IPC: A61K31/685 ,  A61K31/202 ,  A61K31/047 ,  A23L1/29 ,  A61K31/015 ,  A61K31/045 ,  A61K9/48 ,  A61K31/355 ,  A61K31/593

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/48 ,  A61K9/4808 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/065 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K2300/00

Abstract: Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.

Abstract translation: 公开了孕妇和哺乳期妇女的产前和哺乳期补品，其中包括RRR-α-生育酚，二十二碳六烯酸（DHA），反式叶黄素，磷脂以及除RRR-α-生育酚之外的至少一种核受体活化配体的组合， 生育酚，DHA和反式叶黄素。 补充剂可以增强胎儿或母乳喂养新生儿的中枢神经系统发育。

公开(公告)号：US20160219913A1

公开(公告)日：2016-08-04

申请号：US14915552

申请日：2014-08-28

Applicant: Abbott Laboratories

Inventor： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC: A23L1/302 ,  A23D7/005 ,  A23L1/303

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

Abstract translation: 本文公开了具有至少一种蛋白质，至少一种脂肪和至少一种亲脂性化合物的营养组合物，所述组合物包含至少一种包含至少一种疏水性蛋白质，甘油单酯和甘油二酯（“MDG”）的组合物和至少一种 亲脂性化合物，其中营养组合物中总MDG的至少1％在20℃下以100,000×g离心1小时后残留在水相中。

公开(公告)号：US20160213041A1

公开(公告)日：2016-07-28

申请号：US14915548

申请日：2014-08-28

Applicant: ABBOTT LABORATORIES

Inventor： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC: A23D7/005 ,  A23L1/305

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US10328049B2

公开(公告)日：2019-06-25

申请号：US15829412

申请日：2017-12-01

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/375 ,  A23L33/15 ,  A61K31/202 ,  A61K31/05 ,  A23L33/00

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US09844532B2

公开(公告)日：2017-12-19

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/202 ,  A61K31/05 ,  A61K31/375 ,  A23L33/00 ,  A23L33/12 ,  A23L33/15

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US20230114071A1

公开(公告)日：2023-04-13

申请号：US17964609

申请日：2022-10-12

Applicant: Abbott Laboratories

Inventor： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC: A23L33/115 ,  A23L33/00 ,  A23L33/15 ,  A23C9/152 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US20180085343A1

公开(公告)日：2018-03-29

申请号：US15829412

申请日：2017-12-01

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/375 ,  A23L33/15 ,  A61K31/202 ,  A61K31/05 ,  A23L33/00

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.