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公开(公告)号:US20210140640A1
公开(公告)日:2021-05-13
申请号:US16621453
申请日:2018-06-12
Applicant: Indian Institute of Science
Inventor: Saptarshi Basu , Kuppuraj Rajamanickam , Swapneel Roy , Swetaprovo Chaudhuri
IPC: F23R3/28
Abstract: Present disclosure relates to a injector, which comprises a first lance, provisioned with at least one first inlet port, to receive a first fluid. Further, a second lance is coaxially disposed within the first lance, and provisioned with at least one second inlet port, to receive a second fluid. The injector further includes a tube member, disposable within the second lance to receive the first fluid at one end, while sealed at another end. The tube member is provisioned with at least one recess for the first fluid in the tube member to mix with the second fluid and form the effervescent fluid. The effervescent fluid is then dispensed through at least one of a first exit port of the first lance and a second exit port of the second lance. The injector may be employed in applications such as, fuel injection, spray coating and the like.
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公开(公告)号:US20210035470A1
公开(公告)日:2021-02-04
申请号:US16525968
申请日:2019-07-30
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor: Anirudh Katti , Shanthanu Chakravarthy , Ananthasuresh Gondi Kondaiah
Abstract: The present disclosure discloses a compliant mechanism (100) for application of radial resistance on a simulation endoscope (101). The mechanism (100) comprises a support plate (102), a ring member (103) rotatably mounted on the support plate (102) and a plurality of flexible beam assemblies (104) configured in an inner circumference of the ring member (203). The plurality of flexible beam assemblies (104) comprises a first beam (104a) connectable to the ring member (203) and a second beam (104b) connectable to the support plate (102). the circular motion of at least one of the support plate (102) and the ring member (103). relative to each other, moves the plurality of flexible beam assemblies (104) radially inward and radially outward to selectively apply radial resistance on the simulation endoscope (301). The complaint mechanism (100) of present disclosure are joint less mechanisms which are free from backlash and friction in joints.
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13.
公开(公告)号:US20200368348A1
公开(公告)日:2020-11-26
申请号:US16966387
申请日:2019-01-31
Applicant: Emory University , Indian Institute of Science
Inventor: Rama Rao Amara , Andrew Jones , Raghavan Varadarajan
Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.
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14.
公开(公告)号:US20200206313A1
公开(公告)日:2020-07-02
申请号:US16724436
申请日:2019-12-23
Inventor: Steven A. ROSENZWEIG , Hanudatta S. ATREYA , Asampilli GITANJALI , Paturu KONDAIAH
Abstract: Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye.
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公开(公告)号:US20190389799A1
公开(公告)日:2019-12-26
申请号:US16553647
申请日:2019-08-28
Inventor: Bernard LERER , Mugesh GOVINDASAMY , Tzuri LIFSCHYTZ
IPC: C07D207/456 , A61P35/00 , A61P25/24 , C07D517/04 , C07D405/06
Abstract: The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.
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公开(公告)号:US10439643B2
公开(公告)日:2019-10-08
申请号:US15660940
申请日:2017-07-26
Applicant: Indian Institute of Science
Abstract: Embodiments of the present disclosure provide a high speed low latency rate configurable soft decision and hard decision based pipelined Reed-Solomon (RS) decoder architecture suitable for optical communication and storage. The proposed RS decoder is a configurable RS decoder that is configured to monitor the channel and adjust code parameters based on channel capacity. The proposed RS decoder includes interpolation and factorization free Low-Complexity-Chase (LCC) decoding to implement soft-decision decoder (SDD). The proposed RS decoder generates test vectors and feeds these to a pipelined 2-stage hard decision decoder (HDD). The proposed RS decoder architecture computes error locator polynomial in exactly 2t clock cycles without parallelism and supports high throughput, and further computes error evaluator polynomial in exactly t cycles. The present disclosure provides a 2-stage pipelined decoder to operate at least latency possible and reduced size of delay buffer.
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17.
公开(公告)号:US10273564B2
公开(公告)日:2019-04-30
申请号:US15118670
申请日:2014-12-26
Applicant: Indian Institute of Science
Inventor: Surendra Kumar M , Sukla Mondol , Subodh Kumar , Satyam Suwas , K. Chattopadhyay
Abstract: The present disclosure relates to aluminum based alloys and a method for producing the aluminum based alloys. The method comprises acts of, casting of the aluminum based alloy in a chilled casting mold. Then, aging the cast aluminum based alloy at a first predetermined temperature for a first predetermined time. The aging results in the formation of a first precipitate. Followed by this, solutionizing the aluminum based alloy at a second predetermined temperature for a second predetermined time such that the major alloying element is dissolved in aluminum matrix without much affecting the first precipitate. Then, aging the aluminum based alloy at a third predetermined temperature for a third predetermined time. The aging results in the formation of a second precipitate.
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18.
公开(公告)号:US10260154B2
公开(公告)日:2019-04-16
申请号:US15224701
申请日:2016-08-01
Inventor: Shaijumon Mancheri Manikoth , Dijo Damien , Deepesh Gopalakrishnan
IPC: C25B1/00 , C25B9/00 , C01B19/00 , C01G39/06 , C09K11/88 , C01G39/00 , C01G41/00 , B82Y40/00 , B82Y20/00 , B82Y30/00
Abstract: The invention discloses a method for the synthesis of monodispersed luminescent quantum dots of transition metal dichalcogenides (TMDC), single- or few-layered, using a single-step electrochemical exfoliation that involves dilute ionic liquid and water. The method disclosed helps to obtain nanoclusters of TMDC of desired size including small sizes ranging up to 6 nm, by varying the concentration of the electrolyte and the applied DC voltage. The invention further discloses a method by which mono- or few-layered luminescent transition metal dichalcogenides can be directly deposited onto conducting substrates in a uniform manner. The monodispersed single- or few-layered luminescent TMDC and electro-deposited substrates exhibit improved electronic conductivity and new active sites, making them suitable as high-performance electrocatalysts in hydrogen evolution reactions in solar water-splitting applications and also as electrodes for solar cell applications.
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19.
公开(公告)号:US10211200B2
公开(公告)日:2019-02-19
申请号:US15883591
申请日:2018-01-30
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor: Mayank Shrivastava , Milova Paul , Christian Russ , Harald Gossner
Abstract: The present disclosure relates to a Silicon Controlled Rectifier (SCR) in non-planar technology to provide a robust ESD protection in System on Chip employing non-planar technologies. The disclosed SCR incorporates wire or fin shaped nanostructures extending from p-type tap to cathode, from the cathode to anode, and from the anode to n-type tap to provide parallel trigger paths to prevent problem of current crowding at the base emitter junction that limits efficient turn-on in conventional SCRs. The proposed structure helps in offering lower trigger and holding voltage, and therefore very high failure currents. The disclosed SCR has sub-3V trigger and holding voltage to provide an efficient and robust ESD protection in SOCs. The proposed device also offers three times better ESD robustness per unit area. Further the proposed SCR has no added capacitive loading and is compatible with standard process flow and design rules.
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公开(公告)号:US10188136B2
公开(公告)日:2019-01-29
申请号:US15435055
申请日:2017-02-16
Inventor: Sandanaraj Selvaraj Britto , Mullapudi Mohan Reddy , Pavankumar Janardhan Bhandari , Kasuladevu Jagannadha Rao
Abstract: The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.
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