公开(公告)号：US20240207228A1

公开(公告)日：2024-06-27

申请号：US18555103

申请日：2022-04-19

Applicant: ITALFARMACO SPA

Inventor： Gianluca FOSSATI ,  Flavio LEONI ,  Pietro Samuele POZZI ,  Elisabetta GALBIATI ,  Christian STEINKÜHLER

IPC: A61K31/41 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K31/41 ,  A61K39/3955 ,  A61P35/00 ,  A61K2039/545

Abstract: The present invention relates to a combination comprising N-hydroxy-4-((5-(thiophen-2-yl)-1H-tetrazol-1-yl)methyl)benzamide or a pharmaceutically acceptable salt thereof and at least one CTLA4 checkpoint inhibitor, useful in the immunotherapy of tumors and in the treatment of one or more HDAC6-mediated diseases.

公开(公告)号：US10590101B2

公开(公告)日：2020-03-17

申请号：US16315576

申请日：2017-07-14

Applicant: ITALFARMACO SPA

Inventor： Andrea Stevenazzi ,  Giovanni Sandrone ,  Daniela Modena ,  Samuele Pietro Pozzi ,  Barbara Vergani ,  Maria Lattanzio ,  Paolo Mascagni ,  Christian Steinkühler ,  Gianluca Fossati

IPC: C07D317/60 ,  C07D215/14 ,  C07D407/12 ,  C07D213/643 ,  C07D209/18 ,  A61P35/00 ,  C07C259/10 ,  C07D213/56 ,  C07D221/04 ,  C07D233/64 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  A61K31/165 ,  A61K31/357 ,  A61K31/4035 ,  A61K31/443 ,  A61K31/47 ,  C07D317/06

Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.

公开(公告)号：US20190300496A1

公开(公告)日：2019-10-03

申请号：US16315576

申请日：2017-07-14

Applicant: ITALFARMACO SPA

Inventor： Andrea STEVENAZZI ,  Giovanni SANDRONE ,  Daniela MODENA ,  Samuele Pietro POZZI ,  Barbara VERGANI ,  Maria LATTANZIO ,  Paolo MASCAGNI ,  Christian STEINKÜHLER ,  Gianluca FOSSATI

IPC: C07D317/60 ,  C07C259/10 ,  C07D221/04 ,  C07D233/64 ,  C07D213/56 ,  C07D405/12 ,  C07D417/12 ,  C07D409/12 ,  A61P35/00

Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.

公开(公告)号：US20180311160A1

公开(公告)日：2018-11-01

申请号：US15770443

申请日：2016-10-28

Applicant: ITALFARMACO SPA

Inventor： Giuseppe COLOMBO ,  Roberta ARTICO ,  Paolo MASCAGNI ,  Maria Valmen MONZANI ,  Silvia PUCCIANTI

IPC: A61K9/10 ,  A61K9/00 ,  A61K47/26 ,  A61K47/10 ,  A61K47/36 ,  A61K47/12 ,  A61K47/02 ,  A61K31/325 ,  A61P21/00 ,  A61P19/02 ,  A61P35/02 ,  A61P7/02

Abstract: Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.

公开(公告)号：US3781439A

公开(公告)日：1973-12-25

申请号：US3781439D

申请日：1971-02-25

Applicant: ITALFARMACO SPA

Inventor： ZONI G

IPC: A61K31/415 ,  A61K27/00

CPC classification number: A61K31/415

Abstract: 1-(M-TRIFLUOROMETHYLPHENYL)-3-HYDROXY-1H-INDAZOLE OF THE FORMULA:

1-(3-CF3-PHENYL),3-HO-1H-INDAZOLE

AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING IT AS THE ACTIVE INGREDIENT HAVE BEEN FOUND TO HAVE ANALGESIC AND ANTIPHLOGISTIC ACTIVIES.

公开(公告)号：US3511873A

公开(公告)日：1970-05-12

申请号：US3511873D

申请日：1966-10-18

Applicant: ITALFARMACO SPA

Inventor： PICCIOLA GIAMPAOLO

IPC: A61K31/19 ,  C07C101/48

CPC classification number: A61K31/19