公开(公告)号：US07018371B2

公开(公告)日：2006-03-28

申请号：US09851372

申请日：2001-05-07

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M31/00 ,  A61M37/00 ,  A61N5/00

CPC classification number: A61K51/1282 ,  A61M25/002 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1097 ,  A61N5/1001 ,  A61N2005/1003 ,  A61N2005/1004

Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and radiosensitizer delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, banier, coating, infusion lumen, stent, graft, or reservoir for releasing an radiosensitizer to the body lumen.

Abstract translation: 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供与电离辐射组合的受控放射增敏剂递送至患者脉管系统内的选定位置，以减少和/或抑制再狭窄和增生率与增加的功效。 在一个实施方案中，用于抑制增生的组合辐射和放射增敏剂递送导管包括具有近端和远端的导管主体，可耦合到导管体的用于对体腔施加辐射剂量的电离辐射源，以及多孔材料， 基质，膜，放射线，涂层，输液腔，支架，移植物或储器，用于将放射增敏剂释放到体腔。

公开(公告)号：US06537195B2

公开(公告)日：2003-03-25

申请号：US09850721

申请日：2001-05-07

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61N500

CPC classification number: A61N5/1001 ,  A61K51/1282 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2025/1052 ,  A61N2005/1003 ,  A61N2005/1004

Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled drug delivery in combination with x-ray radiation delivery to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and agent delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an agent to the body lumen.

Abstract translation: 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供了将x射线辐射递送到患者脉管系统内的选定位置的受控药物递送，以减少和/或抑制再狭窄和增生的发生率。 在一个实施方案中，用于抑制增生的组合辐射剂和药剂输送导管包括具有近端和远端的导管主体，可与导管主体耦合的X射线管，用于向体腔施加辐射剂量，以及多孔材料 ，基质，膜，屏障，涂层，输液腔，支架，移植物或储存器，用于将药剂释放到体腔。

公开(公告)号：US06377846B1

公开(公告)日：2002-04-23

申请号：US08806244

申请日：1997-02-21

Applicant: Victor I. Chornenky ,  Michael R. Forman

Inventor： Victor I. Chornenky ,  Michael R. Forman

IPC: A61N130

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J35/32 ,  H01J2235/205

Abstract: Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.

Abstract translation: 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。 该器件包括具有薄的金刚石膜作为阴极的阴极结构。 该装置还包括真空壳体和阳极。 描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

公开(公告)号：US6040058A

公开(公告)日：2000-03-21

申请号：US126374

申请日：1998-08-27

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B32B15/08

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶的涂层，使得涂料组合物坚韧地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US5776100A

公开(公告)日：1998-07-07

申请号：US719999

申请日：1996-09-25

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61M25/09 ,  A61M29/00

CPC classification number: A61M25/09 ,  A61M2025/09008 ,  A61M2025/091 ,  A61M2025/09175

Abstract: An infusion guide wire of superelastic nickel titanium is disclosed comprising a lumen extending longitudinally through the wire and a distal portion with a smaller outer diameter than a proximal portion. One or more intermediate portions of intermediate outer diameters can be provided, as well. An occlusion balloon can be attached to the distal portion, and inflated through the lumen. Alternatively, or in conjunction with the occlusion balloon, drugs or other agents can be delivered through the lumen.

Abstract translation: 公开了一种超弹性镍钛的输液引导线，其包括纵向延伸穿过线的内腔和具有比近侧部分更小的外径的远侧部分。 也可以设置中间外径的一个或多个中间部分。 闭塞气囊可以附着到远端部分，并且通过内腔充气。 或者，或者与闭塞气囊一起，药物或其它药剂可以通过管腔输送。

公开(公告)号：US5662960A

公开(公告)日：1997-09-02

申请号：US384711

申请日：1995-02-01

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08J7/00 ,  C08J7/04 ,  B05D3/10 ,  B05D3/04 ,  C23C14/02

CPC classification number: B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G2210/00 ,  C08G2270/00

Abstract: A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

公开(公告)号：US5569197A

公开(公告)日：1996-10-29

申请号：US360488

申请日：1994-12-21

Applicant: Michael N. Helmus ,  Michael R. Forman

Inventor： Michael N. Helmus ,  Michael R. Forman

IPC: A61M25/01 ,  A61F2/06 ,  A61F2/84 ,  A61M25/00 ,  A61M25/09 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/09 ,  A61F2/95 ,  A61M2025/091 ,  A61M2025/09175 ,  A61M25/007 ,  A61M25/104

Abstract: This invention relates to a drug delivery device having a hollow tube which is configured to serve as a guide wire for intraluminal procedures. The distal portion of the tube has at least one opening which has a diameter suitable for the infusion of a drug formulation therethrough. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this drug delivery device in thrombolytic and other intraluminal procedures.

Abstract translation: 本发明涉及具有中空管的药物输送装置，该中空管构造成用作管腔内手术的导丝。 管的远端部分具有至少一个开口，其具有适合于通过其注入药物制剂的直径。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及在血栓溶解和其它腔内手术中使用该药物递送装置的各种方法。

公开(公告)号：US5514092A

公开(公告)日：1996-05-07

申请号：US287121

申请日：1994-08-08

Applicant: Michael R. Forman ,  Lori L. Stowell

Inventor： Michael R. Forman ,  Lori L. Stowell

IPC: A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/104 ,  A61M25/1011 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1079

Abstract: Catheters for drug delivery or for both dilatation and drug delivery are provided with a guide wire lumen terminating within the catheter shaft and having an opening through the catheter shaft to enable a guide wire to exit the catheter shaft substantially distal to the proximal end of the catheter. In one embodiment, drug delivery ports are provided between occlusion balloons. In another embodiment, a dilatation balloon is also provided between the occlusion balloons. In another embodiment, a double layered balloon is provided to simultaneously dilatate the stenosis and deliver medication to the site. Alternatively, a balloon can be provided which only delivers medication.

Abstract translation: 用于药物递送或用于扩张和药物递送的导管设置有终止于导管轴内的导丝管腔，并且具有穿过导管轴的开口，以使引导线能够基本上远离导管的近端离开导管轴 。 在一个实施例中，药物输送端口设置在闭塞气囊之间。 在另一个实施例中，还在闭塞气囊之间设置扩张气囊。 在另一个实施方案中，提供双层气囊以同时扩张狭窄并将药物递送至部位。 或者，可以提供仅输送药物的气囊。

公开(公告)号：US5267959A

公开(公告)日：1993-12-07

申请号：US800201

申请日：1991-11-29

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61M25/16 ,  B29C35/08 ,  B29C65/00 ,  B29C65/14 ,  B29C65/16 ,  A61M29/00

CPC classification number: A61M25/1034 ,  B29C65/1622 ,  B29C65/1635 ,  B29C65/1654 ,  B29C65/1664 ,  B29C65/1667 ,  B29C65/1683 ,  B29C65/1687 ,  B29C65/68 ,  B29C66/1122 ,  B29C66/3452 ,  B29C66/53241 ,  B29C66/5344 ,  B29C66/63 ,  B29C66/65 ,  B29C66/652 ,  B29C66/73921 ,  B29C66/80 ,  A61M2025/1031 ,  A61M25/0009 ,  B29C2035/0822 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1661 ,  B29C66/71 ,  B29K2995/0049 ,  B29K2995/0069 ,  B29L2022/022 ,  B29L2031/7542 ,  B29L2031/7543

Abstract: A balloon catheter which is assembled by a process of selectively concentrating laser energy along an annular fusion bond site at contiguous surface portions of a length of catheter tubing and a shaft or neck portion of a dilatation balloon. The laser energy wavelength, and the polymeric materials of the balloon and catheter, are matched for high absorption of the laser energy to minimize conductive heat transfer in axial directions away from the bond site. This minimizes crystallization and stiffening in regions near the bond site, permitting fusion bonds to be located close to the proximal and distal cones of the dilatation balloon while preserving the soft, pliant quality of the cones.

Abstract translation: 气囊导管，其通过选择性地将激光能量沿着一定长度的导管管线和扩张球囊的轴或颈部部分的连续表面部分处的环形熔合部位集中的过程组装。 激光能量波长以及球囊和导管的聚合物材料匹配，以激光能量的高吸收，以最小化离开粘结部位的轴向方向的传导热传递。 这使得结合位置附近的区域的结晶化和硬化最小化，允许熔融粘合位置靠近扩张球囊的近端和远端锥体，同时保持锥体的柔软，质地良好的质量。

公开(公告)号：US07815561B2

公开(公告)日：2010-10-19

申请号：US10742445

申请日：2003-12-19

Applicant: Michael R. Forman ,  Darius Francescatti ,  Ni Ding

Inventor： Michael R. Forman ,  Darius Francescatti ,  Ni Ding

IPC: A61N5/00

CPC classification number: A61N5/1015 ,  A61N5/1027

Abstract: A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

Abstract translation: 一种乳房近距离放射治疗仪，其提供稳定的半永久/永久性住宅平台，其被配置为在解剖学上复制切除的癌床，并允许更精确的解剖学上正确的有限的放射治疗递送。 该装置可用于将切除的组织空间重建为其手术前的大小和形状，以便于1）促进乳腺癌手术后辅助乳房近距离放射治疗的准确和精确的传递，以及2）由于以下原因：预防/减少术后畸形 手术切除，无论是良性还是恶性疾病，特别是放射治疗乳房肿瘤切除术后患者的恶性疾病。