公开(公告)号：US20210188904A1

公开(公告)日：2021-06-24

申请号：US17196167

申请日：2021-03-09

Applicant: API CORPORATION

Inventor： Masaki NAGAHAMA

IPC: C07K5/062 ,  C07B57/00 ,  C07C231/12 ,  C07C231/20 ,  A61K31/165 ,  C07C237/06 ,  C07C233/47 ,  C07C231/02

Abstract: The present invention provides a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Adopting a particular isomerization-crystallization condition makes it possible to a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Additionally, an intermediate efficacious for producing lacosamide is provided.

公开(公告)号：US20240360086A1

公开(公告)日：2024-10-31

申请号：US18750537

申请日：2024-06-21

Applicant: API CORPORATION

Inventor： Tomoko MAEDA ,  Yasumasa DEKISHIMA ,  Hiroshi KAWABATA ,  Masaki NAGAHAMA ,  Naoyuki WATANABE ,  Kosuke ITO

IPC: C07D239/42 ,  C12N9/04 ,  C12P17/12

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12 ,  C12Y101/01184

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

公开(公告)号：US20240109840A1

公开(公告)日：2024-04-04

申请号：US18007370

申请日：2021-08-27

Applicant: API CORPORATION

Inventor： Shunsuke TSUJI ,  Masaki NAGAHAMA ,  Hirotsugu TANIIKE

IPC: C07C255/33 ,  C07C22/04

CPC classification number: C07C255/33 ,  C07C22/04

Abstract: A method for producing a 2-(halogenated methyl)naphthalene represented by general formula (1):




where X is a halogen atom. The method includes a halogenation process of reacting 2-methylnaphthalene with a halogenating agent under light irradiation, in an organic solvent selected from a halogenated hydrocarbon, an aliphatic ester and an aliphatic hydrocarbon.

公开(公告)号：US20230227400A1

公开(公告)日：2023-07-20

申请号：US18190244

申请日：2023-03-27

Applicant: API CORPORATION

Inventor： Masaki NAGAHAMA ,  Daiki OKADO ,  Hirotsugu TANIIKE

IPC: C07C253/22

CPC classification number: C07C253/22

Abstract: High purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile.

公开(公告)号：US20200283390A1

公开(公告)日：2020-09-10

申请号：US16851402

申请日：2020-04-17

Applicant: API CORPORATION

Inventor： Naoyuki WATANABE ,  Takanobu IURA ,  Hideki OOMIYA ,  Masaki NAGAHAMA

IPC: C07D215/14 ,  C12P17/12

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

公开(公告)号：US20170305867A1

公开(公告)日：2017-10-26

申请号：US15600196

申请日：2017-05-19

Applicant: API CORPORATION

Inventor： Naoyuki WATANABE ,  Tomoko MAEDA ,  Yasumasa DEKISHIMA ,  Hiroshi KAWABATA ,  Masaki NAGAHAMA ,  Kosuke ITO

IPC: C07D239/42 ,  C12P17/12 ,  C12N9/04

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12 ,  C12Y101/01184

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.