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11.发明授权公开(公告)号：US08877489B2
公开(公告)日：2014-11-04
申请号：US13355426
申请日：2012-01-20
Applicant: Yu-Chong Tai , Bo Lu , Mark Humayun
Inventor： Yu-Chong Tai , Bo Lu , Mark Humayun
CPC classification number: A61L27/16 , A61L27/50 , A61L27/56 , A61L2430/16 , B01D71/44 , B01D2325/06 , C12N5/0068 , C12N2533/30 , C12N2535/10 , C12N2539/00
Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
Abstract translation: 公开了具有较厚区域散布的具有光滑前侧和超薄区域（例如，0.01μm至5μm厚）的薄聚对二甲苯C膜。 与光滑的前侧相比，膜的背面可能是粗糙的。 膜可以在体外用于在实验室或体内生长细胞的单层，作为外科手术植入的生长层，例如替代眼睛中的Bruch膜。 聚对二甲苯的薄区域是半渗透性的，以允许血清中的蛋白质通过，并且厚区域给予外科医生处理的机械支持。 光滑的前侧允许单层细胞生长，粗糙的背面有助于防止细胞附着在那里。
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公开(公告)号：US08265606B2
公开(公告)日：2012-09-11
申请号：US12248720
申请日：2008-10-09
Applicant: Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
Inventor： Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
IPC: H04M3/42
CPC classification number: H04L67/306 , G06Q30/02 , H04L12/1859 , H04L51/38 , H04L67/20 , H04L67/22
Abstract: Targeted advertisements to social contacts is described. In embodiment(s), social contacts can be correlated based on messaging interactions between mobile communication devices that are associated with the social contacts. Feedback about an advertisement can be received from mobile communication devices that are associated with the social contacts, and the advertisement can then be targeted to one or more of the social contacts based on the feedback about the advertisement.
Abstract translation: 描述了针对社交联系人的目标广告。 在实施例中，社交联系人可以基于与社交联系人相关联的移动通信设备之间的消息交互相关联。 可以从与社交联系人相关联的移动通信设备接收关于广告的反馈，然后可以基于关于广告的反馈将广告定位到一个或多个社交联系人。
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公开(公告)号：US20120178097A1
公开(公告)日：2012-07-12
申请号：US13118332
申请日：2011-05-27
Applicant: Yu-Chong Tai , Bo Lu
Inventor： Yu-Chong Tai , Bo Lu
CPC classification number: G01N33/5011 , B01D63/087 , B01D65/10 , B01D67/0034 , B01D2325/021 , C12M47/04
Abstract: The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.
Abstract translation: 本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。 这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。 这些重要的设计参数包括过滤器几何设计，流体输送方法，输送机压力和总过滤时间。
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公开(公告)号：US20110087842A1
公开(公告)日：2011-04-14
申请号：US12577464
申请日：2009-10-12
Applicant: Bo Lu , Raghavendra Malpani , Joseph A. Porkka , Bartosz Henryk Paliswiat , Christian Bøgh Jensen , Sushil Kumar
Inventor： Bo Lu , Raghavendra Malpani , Joseph A. Porkka , Bartosz Henryk Paliswiat , Christian Bøgh Jensen , Sushil Kumar
CPC classification number: G06F17/30867 , G06F17/30902
Abstract: Retrieving content items based on a social distance between a user and content providers. The social distance is determined based on, for example, user interaction with the content providers. The content providers are ranked, for the user, based on the determined social distance. Prior to a request from the user, the content items are pre-fetched based on the ranked content providers and constraints such as storage space, bandwidth, and battery power level of a computing device of the user. In some embodiments, additional content items are retrieved, or retrieved content items are deleted, as a variable-size cache on the computing device fills or changes size.
Abstract translation: 基于用户和内容提供商之间的社交距离检索内容项。 基于例如用户与内容提供商的交互来确定社交距离。 内容提供商根据确定的社交距离对用户进行排名。 在来自用户的请求之前，基于排名内容提供商和诸如用户的计算设备的存储空间，带宽和电池功率级别的约束来预取内容项。 在一些实施例中，随着计算设备上的可变大小的高速缓存填充或改变大小，检索附加内容项目或检索到的内容项目。
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公开(公告)号：US20100192698A1
公开(公告)日：2010-08-05
申请号：US12366146
申请日：2009-02-05
Applicant: Mark C. Hansen , Morgan D. Murphy , Thomas Fischer , Bo Lu , Duane D. Fortune , Sandeep D. Punater , Kendall B. Gerhardt , Kevin J. Hawes
Inventor： Mark C. Hansen , Morgan D. Murphy , Thomas Fischer , Bo Lu , Duane D. Fortune , Sandeep D. Punater , Kendall B. Gerhardt , Kevin J. Hawes
IPC: G01L1/12
CPC classification number: B60R21/01516 , B60N2/002 , B60R21/01524 , H01H3/141
Abstract: An occupant presence sensor apparatus disposed in a seat includes first and second substantially non-compliant force translation plates generally parallel to the seating surface of the seat, an elastomeric mat disposed between the first and second force translation plates, and a switch mechanism disposed between the first and second force translation plates within an opening formed in the elastomeric mat. The elastomeric mat includes a distributed array of hollow protuberances that extend toward and contact the force translation plates, and the mat has a stiffness that normally provides a clearance between the switch mechanism and one of the force translation plates. When an occupant of specified or higher weight sits on the seating surface, the protuberances collapse and the force translation plates activate the switch mechanism.
Abstract translation: 设置在座椅中的乘员存在传感器装置包括大致平行于座椅的座面的第一和第二基本上不兼容的力平移板，设置在第一和第二力平移板之间的弹性垫，以及设置在第二和第二力平移板之间的开关机构 在弹性垫中形成的开口内的第一和第二力平移板。 弹性垫包括朝向和接触力平移板延伸的中空突起的分布阵列，并且垫具有通常在开关机构和力平移板之一之间提供间隙的刚度。 当具有特定或更高重量的乘员坐在座位表面上时，突起塌陷并且力平移板激活开关机构。
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Patent Agency Ranking
16.发明授权Systems and methods for manipulating medical data via a decision support system 失效通过决策支持系统操纵医疗数据的系统和方法公开(公告)号：US07213009B2
公开(公告)日：2007-05-01
申请号：US10658998
申请日：2003-09-09
Applicant: Stanley L. Pestotnik , Jonathan B. Olson , Matthew H. Samore , R. Scott Evans , Barry M. Stults , Michael A. Rubin , William H. Tettelbach , William F. Harty, III , Richard J. Boekweg , Bo Lu , David D. Eardley , Michael E. Baza , Mark H. Skolnick , Merle A. Sande
Inventor： Stanley L. Pestotnik , Jonathan B. Olson , Matthew H. Samore , R. Scott Evans , Barry M. Stults , Michael A. Rubin , William H. Tettelbach , William F. Harty, III , Richard J. Boekweg , Bo Lu , David D. Eardley , Michael E. Baza , Mark H. Skolnick , Merle A. Sande
IPC: G06N5/00
CPC classification number: G06Q50/22 , G06F19/00 , G06F19/324 , G06F19/3481 , G16H10/20 , G16H10/60 , G16H50/20 , G16H80/00 , Y02A90/22 , Y02A90/26
Abstract: Disclosed is a method for delivering decision-supported patient data to a clinician to aid the clinician with the diagnosis and treatment of a medical condition. The method including presenting a patient with questions generated by a decision-support module and gathering patient data indicative of the responses to the questions. Each question presented to the patient is based upon the prior questions presented to and the patient data gathered from the patient. Upon receiving the patient data from the client module, evaluating the patient data at the module to generate decision-supported patient data, this supported patient data includes medical condition diagnoses, pertinent medical parameters for the medical condition, and medical care recommendations for the medical condition. At the client module or a clinician's client module, presenting the clinician with this patient data in either a standardized format associated with a progress note or a format selected by the clinician.
Abstract translation: 公开了一种用于将决策支持的患者数据提供给临床医生以帮助临床医师诊断和治疗医疗状况的方法。 该方法包括向患者呈现由决策支持模块产生的问题并收集指示对问题的响应的患者数据。 呈现给患者的每个问题都是基于从患者收集的先前问题和患者数据。 在从客户模块接收到患者数据时，评估模块处的患者数据以产生决策支持的患者数据，该支持的患者数据包括医疗状况诊断，用于医疗状况的相关医疗参数以及用于医疗状况的医疗保健建议 。 在客户端模块或临床医生的客户端模块处，以临床医生选择的进度记录或格式相关联的标准化格式向临床医生呈现该患者数据。
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公开(公告)号：US08815092B2
公开(公告)日：2014-08-26
申请号：US13340516
申请日：2011-12-29
Applicant: Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
Inventor： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
CPC classification number: B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
Abstract: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
Abstract translation: 一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。 多孔膜由聚对二甲苯形成并使用微细加工技术组装。 多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。
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公开(公告)号：US08551425B2
公开(公告)日：2013-10-08
申请号：US12784446
申请日：2010-05-20
Applicant: Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
Inventor： Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
CPC classification number: G01N33/57496 , C12N5/0693 , C12N2503/00 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Y207/07049 , G01N1/30 , G01N1/4077 , G01N33/5094 , G01N2001/4088 , G01N2333/9128 , Y10T436/25375
Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
Abstract translation: 本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器， 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。
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公开(公告)号：US07891260B2
公开(公告)日：2011-02-22
申请号：US12366146
申请日：2009-02-05
Applicant: Mark C. Hansen , Morgan D. Murphy , Thomas Fischer , Bo Lu , Duane D. Fortune , Sandeep D. Punater , Kendall B. Gerhardt , Kevin J. Hawes
Inventor： Mark C. Hansen , Morgan D. Murphy , Thomas Fischer , Bo Lu , Duane D. Fortune , Sandeep D. Punater , Kendall B. Gerhardt , Kevin J. Hawes
IPC: G01L1/26
CPC classification number: B60R21/01516 , B60N2/002 , B60R21/01524 , H01H3/141
Abstract: An occupant presence sensor apparatus disposed in a seat includes first and second substantially non-compliant force translation plates generally parallel to the seating surface of the seat, an elastomeric mat disposed between the first and second force translation plates, and a switch mechanism disposed between the first and second force translation plates within an opening formed in the elastomeric mat. The elastomeric mat includes a distributed array of hollow protuberances that extend toward and contact the force translation plates, and the mat has a stiffness that normally provides a clearance between the switch mechanism and one of the force translation plates. When an occupant of specified or higher weight sits on the seating surface, the protuberances collapse and the force translation plates activate the switch mechanism.
Abstract translation: 设置在座椅中的乘员存在传感器装置包括大致平行于座椅的座面的第一和第二基本上不兼容的力平移板，设置在第一和第二力平移板之间的弹性垫，以及设置在第二和第二力平移板之间的开关机构 在弹性垫中形成的开口内的第一和第二力平移板。 弹性垫包括朝向和接触力平移板延伸的中空突起的分布阵列，并且垫具有通常在开关机构和力平移板之一之间提供间隙的刚度。 当具有特定或更高重量的乘员坐在座位表面上时，突起塌陷并且力平移板激活开关机构。
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公开(公告)号：US20090268414A1
公开(公告)日：2009-10-29
申请号：US12148832
申请日：2008-04-23
Applicant: Bo Lu
Inventor： Bo Lu
CPC classification number: H05K5/0034 , B29C45/14639 , B29C2045/14934 , B29L2031/3481 , H05K3/284 , H05K5/065 , H05K2201/09063 , H05K2201/10015 , H05K2201/10189 , H05K2201/10446 , H05K2201/2018 , H05K2203/1316
Abstract: An over-molded electronic module (2) includes a frame (10), an electronic assembly (20), and a polymeric body (32). The frame (10) includes a sidewall (14) that defines an opening (12) to provide a position for the electronic assembly (20), and includes an upper face (16) and a lower face (18) opposite the upper face (16) to act as sealing surfaces during over-molding. The polymeric body (32) is formed of a polymeric composition encapsulating both sides of the electronic assembly (20) and a portion of the frame (10).
Abstract translation: 包覆模制电子模块（2）包括框架（10），电子组件（20）和聚合体（32）。 框架（10）包括限定开口（12）以提供电子组件（20）的位置的侧壁（14），并且包括与上表面相对的上表面（16）和下表面（18） 16）作为过度成型时的密封面。 聚合物主体（32）由包封电子组件（20）的两侧和框架（10）的一部分的聚合物组合物形成。
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