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公开(公告)号：US20230218807A1
公开(公告)日：2023-07-13
申请号：US18125094
申请日：2023-03-22
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
CPC classification number: A61M1/1603 , A61M1/0272 , A61M1/306 , A61M1/367 , A61M1/3693 , A61M1/3696 , A61M5/16845 , A61M5/16854 , A61M1/3403 , A61M2205/14 , A61M2205/15 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393
Abstract: A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.
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12.发明授权公开(公告)号：US11484891B2
公开(公告)日：2022-11-01
申请号：US16878650
申请日：2020-05-20
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Richard I. Brown , Kyungyoon Min
Abstract: A fluid separation device includes a centrifuge in which a fluid is separated into at least two components, with an interface therebetween. At least a portion of one of the separated fluid components is removed from the centrifuge and flows through a vessel. Light is reflected off of the separated fluid component in the vessel and received and analyzed to determine its main wavelength. If the main wavelength is higher than a maximum value, a target location of the interface is changed. If the main wavelength is less than the maximum value, then the location of the interface is compared to the target location. When the interface is sufficiently close to the target location, the optical density of the separated fluid component in the vessel is compared to a minimum value. If the optical density is less than the minimum value, the target location of the interface is changed.
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公开(公告)号：US20220152630A1
公开(公告)日：2022-05-19
申请号：US17527340
申请日：2021-11-16
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
Abstract: A fluid processing device includes a controller, a centrifuge configured to receive and rotate a continuous-flow centrifuge chamber, a pump system, an optical detection assembly, and a pressure sensor. The controller executes a priming procedure in which a priming fluid is conveyed into the centrifuge chamber while the chamber is being rotated by the centrifuge, which moves air out of the chamber via a low-g outlet conduit. Upon detecting priming fluid exiting the centrifuge chamber via the low-g outlet conduit, the chamber is rotated at a higher rate to attempt to move any remaining air out of the chamber via the low-g outlet conduit. The controller then determines, based on signals from the optical detection assembly and pressure sensor, whether there is any air remaining in the centrifuge chamber. If so, the rotational rate is alternately decreased and increased until all the air has been cleared from the centrifuge chamber.
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14.发明申请公开(公告)号：US20180236405A1
公开(公告)日：2018-08-23
申请号：US15894307
申请日：2018-02-12
Applicant: Fenwal, Inc.
Inventor： Richard I. Brown , Benjamin E. Kusters , Kyungyoon Min
Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
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公开(公告)号：US20250161958A1
公开(公告)日：2025-05-22
申请号：US19023189
申请日：2025-01-15
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Benjamin E. Kusters , Richard I. Brown , Mark J. Brierton
Abstract: An interface monitoring system is provided for detecting the location of an interface between separated fluid components within a channel of a centrifugal separation chamber having a rotational axis. The system includes a light source and a light detector, with the light source being configured to transmit a light along an initial path toward the rotational axis, into the centrifugal separation chamber, and through the channel of the centrifugal separation chamber. The light detector is configured to receive at least a portion of the light as the light exits the centrifugal separation chamber and generate a signal indicative of the location of the interface between separated fluid components within the channel of the centrifugal separation chamber, with the light detector being oriented to receive light traveling in a direction generally perpendicular to the initial path of the light.
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Patent Agency Ranking
公开(公告)号：US20250161542A1
公开(公告)日：2025-05-22
申请号：US18955258
申请日：2024-11-21
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
IPC: A61M1/02
Abstract: Blood processing systems, devices, and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to estimate the concentration of platelets in a donor's circulating blood.
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公开(公告)号：US20250147003A1
公开(公告)日：2025-05-08
申请号：US18938376
申请日：2024-11-06
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , James G. Madsen , Kyle Betancourt
Abstract: An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The controller receives signals from the light detector array that are indicative of the intensity of light received by the light detector array after the light has passed through the fluid. The controller generates a scattering profile based on the signals, with the scattering profile including rising and falling edges each having a slope. The controller calculates one or both slopes and determines the platelet mass index (for a platelet-containing fluid) and/or the concentration of a substance in the fluid based on said slope(s). The optical detection assembly may also be used to analyze a reference fluid having a known concentration of the substance, with signals received by the controller when analyzing the reference fluid being a factor when determining the concentration of the substance in the fluid of interest.
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18.发明申请公开(公告)号：US20250146926A1
公开(公告)日：2025-05-08
申请号：US19018110
申请日：2025-01-13
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Daniel R. Boggs , James Madsen , Jeannette Wu , Matthew Fang
Abstract: An optical detection assembly for monitoring a biological fluid in a vessel includes two fluid-adjustment structures, which are spaced apart and configured to receive at least a portion of a biological fluid-containing vessel therebetween. A light source (which may be associated with one of the fluid-adjustment structures) is configured to emit light through a thickness of the biological fluid in the vessel, while a light detector (which may be associated with the other one of the fluid-adjustment structures) is configured to receive at least a portion of the light from the light source after it has passed through the biological fluid in the vessel. At least a portion of at least one of the fluid-adjustment structures is configured to move with respect to at least a portion of the other one so as to change the thickness of the biological fluid in the monitored portion of the vessel.
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19.发明授权公开(公告)号：US11890399B2
公开(公告)日：2024-02-06
申请号：US16878653
申请日：2020-05-20
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
CPC classification number: A61M1/029 , A61M1/3693 , A61M1/3696 , A61M1/36224 , A61M1/36225 , A61M1/362227 , A61M1/362261 , A61M1/362265 , B04B5/0442 , A61M1/265 , A61M1/38 , A61M2205/50 , A61M2205/7545 , B04B11/02 , B04B2013/006
Abstract: Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.
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公开(公告)号：US11850347B2
公开(公告)日：2023-12-26
申请号：US17128377
申请日：2020-12-21
Applicant: Fenwal, Inc.
Inventor： Christopher J. Wegener , Benjamin E. Kusters
CPC classification number: A61M1/38 , A61M1/0209 , A61M1/3472 , A61M1/3496 , A61M1/3633 , A61M1/3643 , A61M1/3644 , A61M1/0218 , A61M1/3627 , A61M2202/0439 , B01D19/0052 , B01D33/06 , B01D61/24 , B01D61/243
Abstract: The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.
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