公开(公告)号：US20230399538A1

公开(公告)日：2023-12-14

申请号：US18237883

申请日：2023-08-24

Applicant: Innovative Surface Technologies, Inc.

Inventor： Kristin Taton ,  Daniel Guire ,  Nathaniel Olson ,  Eric Guire ,  Patrick Guire

IPC: C09D175/02 ,  A61B5/00 ,  B05D1/02 ,  B05D1/18 ,  C08G18/32 ,  C08G18/50 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C09D5/16

CPC classification number: C09D175/02 ,  A61B5/6846 ,  B05D1/02 ,  B05D1/18 ,  C08G18/3228 ,  C08G18/325 ,  C08G18/5024 ,  C08G18/6685 ,  C08G18/73 ,  C08G18/755 ,  C09D5/1662

Abstract: Durable polyurea copolymer coatings can be applied to surfaces that come in contact with fluids, such as biological fluids, thereby passivating the surface. Polyurea copolymer coating compositions comprise a reaction product of (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; and (b) a diisocyanate. Solutions containing polyurea copolymers, coated surfaces and methods are also described.

公开(公告)号：US11672884B2

公开(公告)日：2023-06-13

申请号：US16771380

申请日：2018-12-11

Applicant: Innovative Surface Technologies, Inc.

Inventor： Kristin Taton ,  Patrick Guire ,  Charles Leir

IPC: A61L31/10 ,  A61L27/34 ,  C08G18/61 ,  C08G18/64 ,  C08G18/73 ,  C08G18/75 ,  C08G18/77 ,  C09D183/10

CPC classification number: A61L27/34 ,  A61L31/10 ,  C08G18/61 ,  C08G18/6423 ,  C08G18/73 ,  C08G18/757 ,  C08G18/778 ,  C09D183/10 ,  C08G2150/00

Abstract: Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.

公开(公告)号：US09814805B2

公开(公告)日：2017-11-14

申请号：US14786842

申请日：2014-04-25

Applicant: INNOVATIVE SURFACE TECHNOLOGIES, INC.

Inventor： Kristin Taton ,  Lawin Laurie ,  Patrick Guire

IPC: A61L29/08 ,  A61L27/54 ,  A61L31/16 ,  A61L31/10 ,  A61L27/34 ,  A61L29/16 ,  A61L29/10 ,  A61L29/06

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/106 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L83/04

Abstract: The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.

公开(公告)号：US09539371B2

公开(公告)日：2017-01-10

申请号：US14749815

申请日：2015-06-25

Applicant: Innovative Surface Technologies, Inc.

Inventor： Jie Wen ,  Kristin Taton ,  Laurie Lawin ,  William Knopke ,  Eric Guire ,  Patrick Guire

IPC: C09D137/00 ,  A61L31/10 ,  C08F8/30 ,  C08F8/42 ,  C09D131/00 ,  A61L31/02 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  B05D3/06

CPC classification number: C08F8/42 ,  A61L29/06 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/0005 ,  A61L2300/404 ,  A61L2300/42 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05D3/06 ,  C08F8/28 ,  C08F8/30 ,  C08F267/04 ,  C09D131/00 ,  C09D135/00 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31573 ,  Y10T428/31598 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31721 ,  Y10T428/3175 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31884 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31928 ,  C08F222/06

Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied.

Abstract translation: 本发明描述了新颖的涂层剂，其包括聚合物，一个或多个潜在反应性基团和一个或多个非共价连接基团，所选择的非共价连接基团与施加涂覆剂的基底相互作用。

公开(公告)号：US20150359944A1

公开(公告)日：2015-12-17

申请号：US14749815

申请日：2015-06-25

Applicant: Innovative Surface Technologies, Inc.

Inventor： Jie Wen ,  Kristin Taton ,  Laurie Lawin ,  William Knopke ,  Eric Guire ,  Patrick Guire

IPC: A61L31/10 ,  A61L31/14 ,  A61L33/00 ,  A61L31/02 ,  A61L31/06 ,  B05D3/06 ,  A61L31/16

CPC classification number: C08F8/42 ,  A61L29/06 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/0005 ,  A61L2300/404 ,  A61L2300/42 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05D3/06 ,  C08F8/28 ,  C08F8/30 ,  C08F267/04 ,  C09D131/00 ,  C09D135/00 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31573 ,  Y10T428/31598 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31721 ,  Y10T428/3175 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31884 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31928 ,  C08F222/06

Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by

Abstract translation: 本发明描述了新颖的涂层剂，其包括聚合物，一个或多个潜在反应性基团和一个或多个非共价连接基团，所选择的非共价连接基团与施加涂覆剂的基底相互作用。 涂层剂可用于提供可以进一步官能化的涂层（例如，

公开(公告)号：US09116144B2

公开(公告)日：2015-08-25

申请号：US13710390

申请日：2012-12-10

Applicant: Innovative Surface Technologies, Inc.

Inventor： Tahmina Naqvi ,  Jie Wen ,  Patrick Guire

IPC: G01N33/48 ,  A61L27/16 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/04 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C12M1/00 ,  D01D5/00 ,  D01F1/10 ,  D01F6/22 ,  D01F6/26 ,  D01F6/62 ,  D06M15/285

CPC classification number: C12N5/0068 ,  A61L27/16 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/041 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/048 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  C12M23/08 ,  C12M23/20 ,  C12M25/14 ,  C12N2533/30 ,  C12N2537/10 ,  C12N2539/00 ,  D01D5/0007 ,  D01F1/10 ,  D01F6/22 ,  D01F6/26 ,  D01F6/625 ,  D06M15/285 ,  D06M2400/01 ,  G01N33/48 ,  C08L33/26

Abstract: A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.

Abstract translation: 刺激响应性纳米纤维，其包括刺激响应聚合物，例如热响应性聚合物，以及具有至少两个潜在反应性可活化基团的交联剂。 纳米纤维还可以包括生物活性材料或功能性聚合物。 刺激性响应性纳米纤维可用于改性基材的表面。 当纳米纤维包含热响应性聚合物时，可以通过控制体系的温度来控制表面的物理性能，从而控制表面结合生物活性物质的能力。

公开(公告)号：US20140205849A1

公开(公告)日：2014-07-24

申请号：US14225567

申请日：2014-03-26

Applicant: Innovative Surface Technologies, Inc.

Inventor： Jie Wen ,  Laurie R. Lawin ,  Patrick Guire

IPC: A61L29/08 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10

CPC classification number: A61L29/085 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/30673 ,  A61L27/00 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  A61L2430/24 ,  C09D4/00 ,  Y10T428/31855 ,  Y10T428/31935

Abstract: The invention provides compositions that include crosslinking agents having multiple photoactivatable groups, such as diaryl ketones, or a diaryl ketone, such as benzophenone, and at least one polymerizable monomer, such as a zwitterionic monomer. The compositions are useful as surface coating agents that provide brush type polymeric coatings. These polymeric coatings can be used on medical devices, such as artificial joints, to reduce wear and tear between the components of the joint and thus reduce or eliminate debris generated by friction between the joint components.

Abstract translation: 本发明提供了包括具有多个可光活化基团的交联剂的组合物，例如二芳基酮或二芳基酮，例如二苯甲酮，和至少一种可聚合单体，例如两性离子单体。 该组合物可用作提供刷式聚合物涂层的表面涂层剂。 这些聚合物涂层可用于诸如人造关节的医疗装置上，以减少接头部件之间的磨损和撕裂，从而减少或消除由接头部件之间的摩擦产生的碎屑。