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公开(公告)号：US11781035B2
公开(公告)日：2023-10-10
申请号：US16771285
申请日：2018-12-11
Applicant: Innovative Surface Technologies, Inc.
Inventor： Kristin Taton , Daniel Guire , Nathaniel Olson , Eric Guire , Patrick Guire
IPC: C08G18/32 , C09D175/02 , A61B5/00 , B05D1/02 , B05D1/18 , C08G18/50 , C08G18/66 , C08G18/73 , C08G18/75 , C09D5/16
CPC classification number: C09D175/02 , A61B5/6846 , B05D1/02 , B05D1/18 , C08G18/325 , C08G18/3228 , C08G18/5024 , C08G18/6685 , C08G18/73 , C08G18/755 , C09D5/1662
Abstract: Durable polyurea copolymer coatings can be applied to surfaces that come in contact with fluids, such as biological fluids, thereby passivating the surface. Polyurea copolymer coating compositions comprise a reaction product of (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; and (b) a diisocyanate. Solutions containing polyurea copolymers, coated surfaces and methods are also described.
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公开(公告)号：US20230241287A1
公开(公告)日：2023-08-03
申请号：US18133259
申请日：2023-04-11
Applicant: Innovative Surface Technologies, Inc.
Inventor： Kristin Taton , Patrick Guire , Charles Leir
CPC classification number: A61L27/34 , A61L31/10 , C08G18/61 , C08G18/6423 , C08G18/73 , C08G18/757 , C08G18/778 , C09D183/10 , C08G2150/00
Abstract: Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.
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公开(公告)号：US20160067385A1
公开(公告)日：2016-03-10
申请号：US14786842
申请日：2014-04-25
Applicant: INNOVATIVE SURFACE TECHNOLOGIES, INC.
Inventor： Kristin Taton , Lawin Laurie , Patrick Guire
CPC classification number: A61L29/085 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/206 , A61L2300/602 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L83/04
Abstract: The present disclosure relates to a multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the coating, methods of using the coating, and articles that include the coating.
Abstract translation: 本公开涉及包括疏水包封层并允许水溶性药物的受控释放的多层涂层。 包裹层用柔性层包裹水溶性或亲水性药物，并与水溶性药物层保持良好的紧密接触。 因此，包裹层符合水溶性药物并且可以控制药物的释放。 有利地，涂层中的主要切口或裂缝不会导致水溶性药物泄漏或爆裂; 相反，包裹层继续提供药物的调节释放。 本公开还包括制备涂层的方法，使用涂层的方法和包括涂层的制品。
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公开(公告)号：US10098989B2
公开(公告)日：2018-10-16
申请号：US15730006
申请日：2017-10-11
Applicant: INNOVATIVE SURFACE TECHNOLOGIES, INC.
Inventor： Kristin Taton , Laurie Lawin , Patrick Guire
Abstract: The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.
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公开(公告)号：US20180043063A1
公开(公告)日：2018-02-15
申请号：US15730006
申请日：2017-10-11
Applicant: INNOVATIVE SURFACE TECHNOLOGIES, INC.
Inventor： Kristin Taton , Laurie Lawin , Patrick Guire
CPC classification number: A61L29/085 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/206 , A61L2300/602 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L83/04
Abstract: The present disclosure relates to a multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the coating, methods of using the coating, and articles that include the coating.
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Patent Agency Ranking
公开(公告)号：US20170081435A1
公开(公告)日：2017-03-23
申请号：US15370410
申请日：2016-12-06
Applicant: Innovative Surface Technologies, Inc.
Inventor： Jie Wen , Kristin Taton , Laurie Lawin , William Knopke , Eric Guire , Patrick Guire
IPC: C08F8/42 , A61L29/08 , A61L29/06 , C08F8/28 , B05D3/06 , A61L31/06 , A61L29/14 , C08F267/04 , A61L29/16 , A61L31/16 , C09D135/00 , A61L31/10
CPC classification number: C08F8/42 , A61L29/06 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/0005 , A61L2300/404 , A61L2300/42 , A61L2400/10 , A61L2420/02 , A61L2420/08 , B05D3/06 , C08F8/28 , C08F8/30 , C08F267/04 , C09D131/00 , C09D135/00 , Y10T428/31507 , Y10T428/31511 , Y10T428/31573 , Y10T428/31598 , Y10T428/31663 , Y10T428/31667 , Y10T428/31721 , Y10T428/3175 , Y10T428/31797 , Y10T428/31855 , Y10T428/31884 , Y10T428/31909 , Y10T428/31913 , Y10T428/31928 , C08F222/06
Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
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公开(公告)号：US12269963B2
公开(公告)日：2025-04-08
申请号：US18237883
申请日：2023-08-24
Applicant: Innovative Surface Technologies, Inc.
Inventor： Kristin Taton , Daniel Guire , Nathaniel Olson , Eric Guire , Patrick Guire
IPC: C09D175/02 , A61B5/00 , B05D1/02 , B05D1/18 , C08G18/32 , C08G18/50 , C08G18/66 , C08G18/73 , C08G18/75 , C09D5/16
Abstract: Durable polyurea copolymer coatings can be applied to surfaces that come in contact with fluids, such as biological fluids, thereby passivating the surface. Polyurea copolymer coating compositions comprise a reaction product of (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; and (b) a diisocyanate. Solutions containing polyurea copolymers, coated surfaces and methods are also described.
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公开(公告)号：US20200377756A1
公开(公告)日：2020-12-03
申请号：US16771285
申请日：2018-12-11
Applicant: Innovative Surface Technologies, Inc.
Inventor： Kristin Taton , Daniel Guire , Nathaniel Olson , Eric Guire , Patrick Guire
IPC: C09D175/02 , C09D5/16 , C08G18/75 , C08G18/73 , C08G18/66 , C08G18/50 , C08G18/32 , A61B5/00 , B05D1/02 , B05D1/18
Abstract: Durable polyurea copolymer coatings can be applied to surfaces that come in contact with fluids, such as biological fluids, thereby passivating the surface. Polyurea copolymer coating compositions comprise a reaction product of (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; and (b) a diisocyanate. Solutions containing polyurea copolymers, coated surfaces and methods are also described.
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公开(公告)号：US10266620B2
公开(公告)日：2019-04-23
申请号：US15370410
申请日：2016-12-06
Applicant: Innovative Surface Technologies, Inc.
Inventor： Jie Wen , Kristin Taton , Laurie Lawin , William Knopke , Eric Guire , Patrick Guire
IPC: C09D137/00 , C08F8/42 , C08F8/30 , C09D131/00 , A61L31/02 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , B05D3/06 , A61L29/06 , A61L29/08 , A61L29/14 , A61L29/16 , C08F8/28 , C08F267/04 , C09D135/00
Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
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公开(公告)号：US20160040121A1
公开(公告)日：2016-02-11
申请号：US14804105
申请日：2015-07-20
Applicant: Innovative Surface Technologies, Inc.
Inventor： Tahmina Naqvi , Jie Wen , Patrick Guire
CPC classification number: C12N5/0068 , A61L27/16 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/048 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , A61L2400/12 , C12M23/08 , C12M23/20 , C12M25/14 , C12N2533/30 , C12N2537/10 , C12N2539/00 , D01D5/0007 , D01F1/10 , D01F6/22 , D01F6/26 , D01F6/625 , D06M15/285 , D06M2400/01 , G01N33/48 , C08L33/26
Abstract: A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.
Abstract translation: 刺激响应性纳米纤维，其包括刺激响应性聚合物，例如热响应性聚合物，以及具有至少两个潜在反应性可活化基团的交联剂。 纳米纤维还可以包括生物活性材料或功能性聚合物。 刺激性响应性纳米纤维可用于改性基材的表面。 当纳米纤维包含热响应性聚合物时，可以通过控制体系的温度来控制表面的物理性能，从而控制表面结合生物活性物质的能力。
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