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公开(公告)号：US20180275388A1
公开(公告)日：2018-09-27
申请号：US15763061
申请日：2016-09-23
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B7/38 , G02B21/02 , G02B21/18 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/361 , G03B13/36 , H04N5/23212
Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20240161299A1
公开(公告)日：2024-05-16
申请号：US18390196
申请日：2023-12-20
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen OLSON , Chris CAMARATTA
IPC: G06T7/00
CPC classification number: G06T7/0014 , G06T2207/30004 , G06T2207/30168
Abstract: Methods and systems method for determining quality of an image after a system configuration change. A method includes receiving an indication of a configuration update of an imaging system, processing a test image using the image display system to generate updated test image pixel data for display on the imaging system, determining if the updated test image pixel data is different than the ground truth pixel data of the test image by more than a quality threshold, and in response to the updated test image pixel data being different than the ground truth pixel data of the test image by more than the quality threshold, generate in indicator that the configuration change adversely affected the image generation properties of the imaging system.
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公开(公告)号：US20220342479A1
公开(公告)日：2022-10-27
申请号：US17859765
申请日：2022-07-07
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen OLSON , Kiran SALIGRAMA
IPC: G06F3/01 , G16H40/67 , G16H30/20 , G06F3/0485
Abstract: Image viewing in digital pathology using eye-tracking. In an embodiment, a position of a user's gaze on a graphical user interface, comprising at least a portion of a digital slide image within a macro view, is repeatedly detected based on an output from an eye-tracking device. After detecting a change of the user's gaze from a first position to a second position on the graphical user interface, a view of the digital slide image within the macro view is automatically panned based on the second position, so as to move a position on the digital slide image that corresponds to the second position on the graphical user interface toward a center of the macro view.
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公开(公告)号：US20210048344A1
公开(公告)日：2021-02-18
申请号：US17086099
申请日：2020-10-30
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Allen OLSON
IPC: G01J3/46 , G01J3/50 , G01N1/30 , G01J1/08 , G01J3/10 , G01J3/28 , G02B21/32 , G06T7/80 , G06T7/33 , G06T7/90 , G01N21/27 , G02B21/36 , G06T3/00 , G06T3/40 , G06T7/00
Abstract: Color calibration for digital pathology is provided. A standard glass slide is prepared with a specimen having zero or more stains. The specimen is scanned a first time using a hyperspectral imaging system to produce a first digital image having XYZ color values. The specimen is scanned a second time using a digital pathology imaging system to produce a second digital image having RGB color values. The first and second digital images are then registered against each other to align the digital image data. Individual pixels of the first and second images may be combined in the registration process so that the first and second digital images have substantially similar pixel sizes. A lookup table is generated to associate XYZ color values to RGB color values. Once the lookup table has been generated, it can be used to present RGB color on a display using the corresponding XYZ color.
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公开(公告)号：US20190164519A1
公开(公告)日：2019-05-30
申请号：US16206478
申请日：2018-11-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen OLSON , Ruben CAMPOS ZURRIAGA , Reiner JUNG
IPC: G09G5/02
Abstract: Described herein are systems and methods that place a known color monitor (known by unique serial number or SKU) into a desired state for displaying digital pathology image data. Using an application programming interface, any color monitor that implements MCCS can be calibrated and characterized immediately before each display of digital pathology image data and can also be periodically reset (if needed) during display of digital pathology image data.
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Patent Agency Ranking
公开(公告)号：US20190101739A1
公开(公告)日：2019-04-04
申请号：US16147465
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B21/006 , G02B21/0076 , G02B21/008 , G06T7/50 , G06T2207/10061 , G06T2207/10064 , H04N5/37206
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20220019281A1
公开(公告)日：2022-01-20
申请号：US17281907
申请日：2019-12-19
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Allen OLSON , Kiran SALIGRAMA
IPC: G06F3/01 , G06F3/0485 , G16H30/20 , G16H40/67
Abstract: Image viewing in digital pathology using eye-tracking In an embodiment, a position of a user's gaze on a graphical user interface, comprising at least a portion of a digital slide image within a macro view, is repeatedly detected based on an output from an eye-tracking device. After detecting a change of the user's gaze from a first position to a second position on the graphical user interface, a view of the digital slide image within the macro view is automatically panned based on the second position, so as to move a position on the digital slide image that corresponds to the second position on the graphical user interface toward a center of the macro view.
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公开(公告)号：US20210103134A1
公开(公告)日：2021-04-08
申请号：US17105251
申请日：2020-11-25
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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19.发明申请公开(公告)号：US20190206056A1
公开(公告)日：2019-07-04
申请号：US16230820
申请日：2018-12-21
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Walter GEORGESCU , Allen OLSON , Bharat ANNALDAS , Darragh LAWLER , Kevin SHIELDS , Kiran SALIGRAMA , Mark GREGSON
Abstract: A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.
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公开(公告)号：US20190101723A1
公开(公告)日：2019-04-04
申请号：US16147448
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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