公开(公告)号：US10548521B2

公开(公告)日：2020-02-04

申请号：US15884365

申请日：2018-01-30

Applicant: MediBeacon Inc.

Inventor： Kimberly Schultz ,  Jennifer Keating ,  Edward Solomon ,  Kate Bechtel

IPC: G06F11/30 ,  A61B5/1455 ,  G01J1/44 ,  A61B5/00 ,  G01J1/04

Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.

公开(公告)号：US20180214062A1

公开(公告)日：2018-08-02

申请号：US15884371

申请日：2018-01-30

Applicant: MediBeacon Inc.

Inventor： Jennifer Keating ,  Kimberly Shultz ,  Kate Bechtel ,  Edward Solomon

IPC: A61B5/20 ,  G01J1/44 ,  G01J1/04 ,  A61B5/00 ,  A61K49/00

CPC classification number: A61B5/201 ,  A61B5/0071 ,  A61B2560/0228 ,  A61K49/0004 ,  A61K49/0021 ,  G01J1/0488 ,  G01J1/44 ,  G01J3/027 ,  G01J3/10 ,  G01J3/28 ,  G01J3/4406 ,  G01N21/4738 ,  G01N21/6408 ,  G01N21/645 ,  G01N2201/0625

Abstract: A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrmeas signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRexmeas DRem, and DRem,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrmeas signal within the post-equilibration portion of the measurement data set to an IFagent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flrmeas signal.