公开(公告)号：US10527757B2

公开(公告)日：2020-01-07

申请号：US15792807

申请日：2017-10-25

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Fei Cheng ,  Ying Zheng

IPC: G02B1/04 ,  C08G77/20 ,  C08G77/28 ,  C08J3/075 ,  C08L25/06 ,  C08L33/10 ,  C08L83/08 ,  B29D11/00 ,  C08F283/12 ,  C08F290/06 ,  C08F299/08 ,  C08J3/24

Abstract: The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.

公开(公告)号：US10465047B2

公开(公告)日：2019-11-05

申请号：US15727674

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/38 ,  G02C7/04 ,  C08F20/06 ,  C08F26/10 ,  C08F299/08 ,  C08G77/20 ,  C08G77/46

Abstract: The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segments, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention.

公开(公告)号：US20190023935A1

公开(公告)日：2019-01-24

申请号：US16036988

申请日：2018-07-17

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08F220/56 ,  C08F220/28 ,  C08F220/38 ,  C09D133/14 ,  C09D179/08 ,  C09D5/02 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US20180356562A1

公开(公告)日：2018-12-13

申请号：US16000930

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00134 ,  C08F230/08 ,  C08L83/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20180355112A1

公开(公告)日：2018-12-13

申请号：US16000933

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08G77/12 ,  C08L83/10 ,  G02B1/04

CPC classification number: C08G77/442 ,  B29D11/00134 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G2210/00 ,  C08L83/10 ,  C08L2201/10 ,  G02B1/043 ,  G02B2207/109 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US10081697B2

公开(公告)日：2018-09-25

申请号：US15376700

申请日：2016-12-13

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  C08G77/12

CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/392 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20180362697A1

公开(公告)日：2018-12-20

申请号：US16110194

申请日：2018-08-23

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08F290/06 ,  C08G77/20 ,  C08G77/16

CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/392 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20180100053A1

公开(公告)日：2018-04-12

申请号：US15727666

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Feng Jing ,  Frank Chang

IPC: C08K5/00 ,  C08K5/5419 ,  C08G77/14

CPC classification number: C08K5/0025 ,  C08F2810/20 ,  C08G77/14 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08K5/5419 ,  G02C7/04

Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.