公开(公告)号：US20210278656A1

公开(公告)日：2021-09-09

申请号：US17322903

申请日：2021-05-18

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  James Ulcickas ,  Fengyuan Deng ,  Changqin Ding

IPC: G02B21/36 ,  G01N21/21 ,  G06T5/00 ,  G02B21/26 ,  G02B21/06

Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.

公开(公告)号：US20200082282A1

公开(公告)日：2020-03-12

申请号：US16566840

申请日：2019-09-10

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  James Ulcicks ,  Casey Smith ,  Alex Sherman

IPC: G06N5/04 ,  G06N3/04

Abstract: A method for inducing a covert misclassification performed on a non-transitory computer readable medium, the method includes identifying a target position. The method further includes creating a spectral perturbation tensor. The spectral perturbation tensor is configured to shift a projection of an initial spectrum towards the target position. Additionally, the method includes combining the spectral perturbation tensor to the initial spectrum. Further, the method includes classifying the combination of the spectral perturbation tensor and the initial spectrum with an established classifier, thereby designing the spectral perturbation tensor such that the combination is misclassified.

公开(公告)号：US10145968B2

公开(公告)日：2018-12-04

申请号：US14708335

申请日：2015-05-11

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Garth Jason Simpson ,  Ryan Douglas Muir ,  Nicholas Roman Pogranichniy

IPC: G01T1/36 ,  G01T1/24 ,  G01T1/17

Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.

公开(公告)号：US20180313764A1

公开(公告)日：2018-11-01

申请号：US15770930

申请日：2016-09-27

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt ,  Scott Robert Griffin ,  Casey Jake Smith

IPC: G01N21/70 ,  G01N21/01

CPC classification number: G01N21/70

Abstract: An impact-driven apparatus and method to achieve triboluminescence of homochiral API crystals as a measurement tool for rapidly assessing the presence of trace crystallinity within nominally amorphous pharmaceutical powders. The apparatus may include a kinetic energy director and two plates which hold a sample for testing. The triboluminescence may also be achieve by an acoustic transducer.

公开(公告)号：US20180052103A1

公开(公告)日：2018-02-22

申请号：US15555588

申请日：2016-03-04

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Garth Jason Simpson ,  Justin Allen Newman ,  Nicholas Roman Pogranichniy ,  Nicole Mulready Scarborough

IPC: G01N21/63 ,  G01N23/207 ,  G01N33/52 ,  G01N33/58 ,  G01N33/68 ,  G02F1/37

CPC classification number: G01N21/636 ,  G01N23/207 ,  G01N33/52 ,  G01N33/58 ,  G01N33/68 ,  G02F1/37

Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.

公开(公告)号：US12039461B2

公开(公告)日：2024-07-16

申请号：US16566840

申请日：2019-09-10

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  James Ulcickas ,  Casey Smith ,  Alex Sherman

IPC: G06N5/04 ,  G05B13/02 ,  G06N3/02 ,  G06N3/045 ,  G06F17/14 ,  G06F17/16

CPC classification number: G06N5/04 ,  G05B13/025 ,  G06N3/02 ,  G06N3/045 ,  G06F17/14 ,  G06F17/16

Abstract: A method for inducing a covert misclassification performed on a non-transitory computer readable medium, the method includes identifying a target position. The method further includes creating a spectral perturbation tensor. The spectral perturbation tensor is configured to shift a projection of an initial spectrum towards the target position. Additionally, the method includes combining the spectral perturbation tensor to the initial spectrum. Further, the method includes classifying the combination of the spectral perturbation tensor and the initial spectrum with an established classifier, thereby designing the spectral perturbation tensor such that the combination is misclassified.

公开(公告)号：US11619581B2

公开(公告)日：2023-04-04

申请号：US17239683

申请日：2021-04-26

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Fengyuan Deng ,  Changqin Ding ,  Chen Li

IPC: G01B9/02 ,  G01N21/45 ,  G02B5/30

Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.

公开(公告)号：US20220057266A1

公开(公告)日：2022-02-24

申请号：US17518761

申请日：2021-11-04

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Chen Li ,  Changqin Li

IPC: G01J3/447 ,  G01J3/02

Abstract: A method for phase contrasting-correlation spectroscopy: converting an incident linearly polarized light into two polarized components (polarized divergent and convergent components, wherein the polarized divergent component is orthogonal to the polarized convergent component), focusing each of the polarized divergent component and the polarized convergent component into a focal plane, thereby producing two focus planes constituting a reference focus (RF) plane and a sample focus (SF) plane; placing a sample at the SF plane and ambient conditions of the sample at the RF plane, resulting in a phase shift between the two polarized components; reconstituting the two phase-shifted polarized components into a phase-shifted linearly polarized light; detecting the phase-shifted linearly polarized light; calculating phase and intensity of the sample from the phase-shifted linearly polarized light; establishing an autocorrelation of phase and intensity of the phase-shifted linearly polarized light; and generating correlograms of intensity and phase of the phase-shifted linearly polarized light.

公开(公告)号：US11009456B2

公开(公告)日：2021-05-18

申请号：US16560949

申请日：2019-09-04

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Fengyuan Deng ,  Changqin Ding ,  Chen Li

IPC: G01B9/02 ,  G01N21/45 ,  G02B5/30

Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.

公开(公告)号：US10162942B2

公开(公告)日：2018-12-25

申请号：US15702383

申请日：2017-09-12

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Garth Jason Simpson ,  Ryan Douglas Muir ,  David Joseph Kissick

IPC: G06F12/08 ,  G06F19/00 ,  G01J1/16 ,  G01J1/42 ,  G01T1/17 ,  G01J1/44

Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.