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    Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption
    13.
    发明授权
    Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption 有权

    公开(公告)号：US11867620B2

    公开(公告)日：2024-01-09

    申请号：US17600438

    申请日：2019-12-10

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Yeran Bai ,  Delong Zhang ,  Ali Shakouri ,  D. Kerry Maize

    IPC: G01N21/3577

    CPC classification number: G01N21/3577 ,  G01N2201/06113

    Abstract: Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.

    Vibrational photoacoustic tomography using Raman laser
    14.
    发明授权
    Vibrational photoacoustic tomography using Raman laser 有权
    使用拉曼激光的振动光声层析成像

    公开(公告)号：US09357928B2

    公开(公告)日：2016-06-07

    申请号：US14156946

    申请日：2014-01-16

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng

    IPC: A61B5/05 ,  A61B5/00

    CPC classification number: A61B5/0095

    Abstract: A method of noninvasively imaging tissue within a body includes irradiating the tissue using an imaging laser including a Raman-based laser tuner, the radiation including a plurality of laser pulses, each having energy greater than 100 mJ; receiving an acoustic signal generated by vibrational energy in the tissue, wherein the vibrational energy is a result of selective overtone excitation of molecules in the tissue by the radiation; and automatically converting the acoustic signal to an image representative of the tissue using a processor. An imaging system includes an imaging laser configured to irradiate tissue with a plurality of laser pulses using a Raman-based laser tuner. An ultrasonic transducer receives an acoustic signal generated by vibrational energy in the tissue due to overtone excitation by the radiation. A processor is configured to automatically produce an image representative of the tissue using the received acoustic signal.

    Abstract translation: 一种在体内非侵入性地成像组织的方法包括使用包括基于拉曼的激光调谐器的成像激光器照射组织，该辐射包括多个激光脉冲，每个激光脉冲具有大于100mJ的能量; 接收由所述组织中的振动能产生的声信号，其中所述振动能是由所述辐射对所述组织中的分子的选择性泛音激励的结果; 并使用处理器自动地将声信号转换成代表组织的图像。 一种成像系统包括：成像激光器，被配置为使用基于拉曼的激光调谐器来照射具有多个激光脉冲的组织。 超声换能器由于辐射的泛音激励而接收由组织中的振动能产生的声信号。 处理器被配置为使用所接收的声信号自动产生代表组织的图像。

    Method and device for optical imaging with a resonant amplifier assembly
    15.
    发明授权
    Method and device for optical imaging with a resonant amplifier assembly 有权
    用于具有谐振放大器组件的光学成像的方法和装置

    公开(公告)号：US09222878B2

    公开(公告)日：2015-12-29

    申请号：US14373197

    申请日：2013-01-20

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Mikhail N. Slipchenko ,  Robert A. Oglesbee

    IPC: G01N21/00 ,  G01N21/17 ,  G01N21/65 ,  G02B21/00 ,  G02B21/16 ,  G01J3/28 ,  G01J3/44 ,  G01B9/04 ,  G01J1/46

    CPC classification number: G01N21/17 ,  G01B9/04 ,  G01J1/46 ,  G01J3/2803 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/655 ,  G01N2201/12 ,  G02B21/002 ,  G02B21/16

    Abstract: An optical imaging apparatus includes an optical signal source, an optical signal detector apparatus, and a resonant amplifier assembly. The optical signal source is configured (i) to generate an optical signal including a carrier signal and an imaging signal, and (ii) to guide the optical signal to a sample. The optical signal detector apparatus is configured (i) to detect a modified optical signal from the sample, and (ii) to generate an electrical image signal based on the modified optical signal. The electrical image signal includes a background component and a modulated image signal corresponding to an image of the sample. The resonant amplifier assembly is electrically coupled to the optical signal detector apparatus and is configured (i) to isolate the modulated image signal from the background component, (ii) to amplify the modulated image signal, and (iii) to rectify the modulated image signal.

    Abstract translation: 光学成像装置包括光信号源，光信号检测装置和谐振放大器组件。 光信号源被配置为（i）产生包括载波信号和成像信号的光信号，以及（ii）将光信号引导到样本。 光信号检测器装置被配置为（i）检测来自样本的修改的光信号，以及（ii）基于修改的光信号产生电图像信号。 电图像信号包括对应于样本图像的背景分量和调制图像信号。 谐振放大器组件电耦合到光信号检测器装置，并且被配置为（i）将调制的图像信号与背景分量隔离，（ii）放大调制的图像信号，以及（iii）校正调制的图像信号 。

    DEPTH-RESOLVED MID-INFRARED PHOTOTHERMAL IMAGING OF LIVING CELLS AND ORGANISMS WITH SUB-MICRON SPATIAL RESOLUTION
    17.
    发明申请
    DEPTH-RESOLVED MID-INFRARED PHOTOTHERMAL IMAGING OF LIVING CELLS AND ORGANISMS WITH SUB-MICRON SPATIAL RESOLUTION 有权

    公开(公告)号：US20220349818A1

    公开(公告)日：2022-11-03

    申请号：US17698215

    申请日：2022-03-18

    Applicant: Purdue Research Foundation

    Inventor： Delong Zhang ,  Ji-Xin Cheng

    IPC: G01N21/3563 ,  G01N21/17 ,  C12Q1/02 ,  G01J5/22

    Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

    Stimulated Raman spectroscopic microscope by resonant delay-line tuning
    18.
    发明授权
    Stimulated Raman spectroscopic microscope by resonant delay-line tuning 有权

    公开(公告)号：US10928324B2

    公开(公告)日：2021-02-23

    申请号：US16470119

    申请日：2017-12-14

    Applicant: Purdue Research Foundation ,  Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

    Inventor： Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

    IPC: G01J3/44 ,  G01N21/65 ,  G01J3/10 ,  G01J3/433

    Abstract: A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.

    System and method for multiplex spectroscopic imaging
    19.
    发明授权
    System and method for multiplex spectroscopic imaging 有权
    多光谱成像系统和方法

    公开(公告)号：US09068949B2

    公开(公告)日：2015-06-30

    申请号：US14171052

    申请日：2014-02-03

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Mikhail N. Slipchenko ,  Robert A. Oglesbee

    IPC: G01J3/28 ,  G01N21/65 ,  G01J3/02

    CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/2803

    Abstract: A system for measuring an sample includes an illumination source providing electromagnetic radiation pulses at a selected temporal frequency. A microscope focuses the radiation to interact with the sample and produce resultant electromagnetic radiation. A disperser disperses wavelengths of the resultant radiation onto optical sensors, and respective resonant amplifiers amplify signals having the selected temporal frequency. Optical detection apparatus includes the optical sensors, resonant amplifiers, and disperser. The resonant amplifiers amplify portion(s) of their inputs having a selected temporal frequency and attenuate other portion(s). A method of analyzing constituents of a sample includes contemporaneously irradiating the sample with narrowband light and broadband light, the optical power of either modulated at a selected temporal frequency; dispersing wavelengths of resultant light across the optical detectors; and filtering respective signals from the optical detectors to provide spectrum data including signals corresponding to the selected temporal frequency.

    Abstract translation: 用于测量样本的系统包括以选定的时间频率提供电磁辐射脉冲的照明源。 显微镜将放射线与样品相互作用并产生电磁辐射。 分散器将所得辐射的波长分散到光学传感器上，并且相应的谐振放大器放大具有所选择的时间频率的信号。 光学检测装置包括光学传感器，谐振放大器和分散器。 谐振放大器放大其输入的具有选定时间频率的部分，并衰减其它部分。 分析样品成分的方法包括同时以窄带光和宽带光照射样品，以选定的时间频率调制的光功率; 将所得光的波长分散在光学检测器上; 并且对来自光学检测器的各个信号进行滤波以提供包括对应于所选择的时间频率的信号的频谱数据。

    METHOD AND DEVICE FOR OPTICAL IMAGING WITH A RESONANT AMPLIFIER ASSEMBLY
    20.
    发明申请
    METHOD AND DEVICE FOR OPTICAL IMAGING WITH A RESONANT AMPLIFIER ASSEMBLY 有权
    用于具有谐振放大器组件的光学成像的方法和装置

    公开(公告)号：US20140361150A1

    公开(公告)日：2014-12-11

    申请号：US14373197

    申请日：2013-01-20

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Mikhail N. Slipchenko ,  Robert A. Oglesbee

    IPC: G01N21/17 ,  G01B9/04

    CPC classification number: G01N21/17 ,  G01B9/04 ,  G01J1/46 ,  G01J3/2803 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/655 ,  G01N2201/12 ,  G02B21/002 ,  G02B21/16

    Abstract: An optical imaging apparatus includes an optical signal source, an optical signal detector apparatus, and a resonant amplifier assembly. The optical signal source is configured (i) to generate an optical signal including a carrier signal and an imaging signal, and (ii) to guide the optical signal to a sample. The optical signal detector apparatus is configured (i) to detect a modified optical signal from the sample, and (ii) to generate an electrical image signal based on the modified optical signal. The electrical image signal includes a background component and a modulated image signal corresponding to an image of the sample. The resonant amplifier assembly is electrically coupled to the optical signal detector apparatus and is configured (i) to isolate the modulated image signal from the background component, (ii) to amplify the modulated image signal, and (iii) to rectify the modulated image signal.

    Abstract translation: 光学成像装置包括光信号源，光信号检测装置和谐振放大器组件。 光信号源被配置为（i）产生包括载波信号和成像信号的光信号，以及（ii）将光信号引导到样本。 光信号检测器装置被配置为（i）检测来自样本的修改的光信号，以及（ii）基于修改的光信号产生电图像信号。 电图像信号包括对应于样本图像的背景分量和调制图像信号。 谐振放大器组件电耦合到光信号检测器装置，并且被配置为（i）将调制的图像信号与背景分量隔离，（ii）放大调制的图像信号，以及（iii）校正调制的图像信号 。

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