公开(公告)号：US20210393786A1

公开(公告)日：2021-12-23

申请号：US17263451

申请日：2019-07-20

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Xin Liu

IPC: A61K47/55 ,  A61K47/54 ,  A61K51/04 ,  A61K49/00

Abstract: Disclosed herein is a small molecule targeted drug conjugate for anti-influenza chemotherapy and immunotherapy. The disclosed drug conjugate may form an adaptor to recruit additional CAR T cells or other immune cells for precise elimination of influenza virus-infected cells in a subject. Concurrently administered antibodies or pre-existing immunity in influenza-virus infected subject works well with the targeted conjugate to eliminate virus infected cells, saving valuable time for rescuing late stage patients.

公开(公告)号：US11141494B2

公开(公告)日：2021-10-12

申请号：US15501630

申请日：2015-08-07

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Ananda Kumar Kanduluru ,  Philip S. Low

IPC: A61K49/00 ,  C07K14/705 ,  C09B23/01 ,  C09B11/24 ,  A61K31/404 ,  A61K51/04 ,  A61K31/4545 ,  A61K31/475 ,  A61K38/05 ,  A61K51/06 ,  A61K51/08

Abstract: Neurokinin-1 (NK-1) receptor-binding agent delivery conjugates, compositions comprising NK-1 receptor-binding agent delivery conjugates, and methods for making and administering NK-1 receptor-binding agent delivery conjugates are provided. A conjugate may include an NK-1 receptor-binding moiety, a linker group containing at least one linker selected from the group of a releasable linker and a spacer linker, and an active agent linked to the linker group. The active agent may be selected from the group of fluorophore-containing compounds, radionuclide-containing compounds, and therapeutic agents for treatment of tumor cells characterized by over-expression of the NK-1 receptor.

公开(公告)号：US10828282B2

公开(公告)日：2020-11-10

申请号：US15990152

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/54 ,  A61K47/64 ,  A61K51/04 ,  A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20200261592A1

公开(公告)日：2020-08-20

申请号：US16869268

申请日：2020-05-07

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K51/08 ,  A61K51/04 ,  A61K47/54 ,  A61K49/00 ,  C07C323/52 ,  C07K5/08 ,  A61K31/475 ,  A61K31/426 ,  A61K31/4745 ,  C07D207/416

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20190291109A1

公开(公告)日：2019-09-26

申请号：US16275912

申请日：2019-02-14

Applicant: Purdue Research Foundation

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

IPC: B01L3/00 ,  G01N33/574 ,  G01N33/543 ,  G01N27/74

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

公开(公告)号：US10207267B2

公开(公告)日：2019-02-19

申请号：US15355792

申请日：2016-11-18

Applicant: Purdue Research Foundation

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

IPC: G01N33/553 ,  B01L3/00 ,  G01N33/543 ,  G01N27/74 ,  G01N33/574 ,  G01N1/40

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

公开(公告)号：US10080805B2

公开(公告)日：2018-09-25

申请号：US14380273

申请日：2013-02-22

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Charity Wayua

IPC: A61K51/00 ,  A61M36/14 ,  A61K47/48 ,  C07D405/12 ,  C07D243/12 ,  A61K51/04 ,  A61K31/4409 ,  A61K31/475 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K49/00 ,  A61K51/02

CPC classification number: A61K47/545 ,  A61K31/4409 ,  A61K31/475 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K49/0052 ,  A61K51/02 ,  A61K51/0468 ,  A61K51/047 ,  C07D243/12 ,  C07D405/12

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

公开(公告)号：US09731035B2

公开(公告)日：2017-08-15

申请号：US13793654

申请日：2013-03-11

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Andrew R. Hilgenbrink

IPC: A61K51/04 ,  A61K49/00 ,  A61K38/19 ,  A61K47/48 ,  A61K38/47 ,  C09B11/24

CPC classification number: A61K51/044 ,  A61K38/19 ,  A61K38/47 ,  A61K47/545 ,  A61K47/551 ,  A61K47/64 ,  A61K47/6911 ,  A61K49/0021 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K51/0459 ,  C09B11/24

Abstract: The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.

公开(公告)号：US20170131283A1

公开(公告)日：2017-05-11

申请号：US15355792

申请日：2016-11-18

Applicant: Purdue Research Foundation

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

IPC: G01N33/574 ,  G01N33/543 ,  G01N27/74

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

公开(公告)号：US09233175B2

公开(公告)日：2016-01-12

申请号：US14135099

申请日：2013-12-19

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Lindsay E. Kelderhouse ,  Sakkarapalayam M. Mahalingam

IPC: A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods of imaging of inflammatory diseases using the compounds.

Abstract translation: 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了使用该化合物成像炎性疾病的方法。