Abstract:
System and method for fluorescent light detection from biological samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
Abstract:
A method for calibrating a production printing cartridge for use in an imaging system includes the steps of obtaining first standard cartridge signature color data associated with a standard printing cartridge and a first substrate, obtaining second standard cartridge signature color data associated with the standard printing cartridge and a second substrate, obtaining first production cartridge signature color data associated with the production printing cartridge and the first substrate, and estimating second production cartridge signature color data associated with the production printing cartridge and the second substrate based on the first standard cartridge signature color data, the second standard cartridge signature color data, and the first production cartridge signature color data.
Abstract:
System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
Abstract:
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
Abstract:
A method for correcting cartridge color shifts for imaging with an imaging apparatus includes determining a spectral signature band for each colorant to yield a plurality of spectral signature bands; determining a minimum number of the spectral signature bands from the plurality of spectral signature bands to form a group of spectral signature bands that are applicable to all colorants of the plurality of colorants; determining a primary colorant profile for each colorant of the plurality of colorants of the cartridge based on the minimum number of the spectral signature bands; determining primary colorant shift data based on the primary colorant profile for each colorant and based on a standard cartridge primary colorant profile; estimating combined colorant shift data using the primary colorant shift data; and generating color correction data based on the combined colorant shift data for use in imaging with an imaging apparatus using the cartridge.
Abstract:
Various embodiments described in the application relate to an apparatus, system, and method for fluidically controlling, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise combinations of detectors, controllers, valves, and fluid supply units to control the spatial size, location and/or fluidic composition of discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
Abstract:
A method for converting a source gamut of an image to a destination gamut includes providing an imaging apparatus having a plurality of destination gamuts, determining a source gamut boundary for the source gamut of the image; selecting an appropriate destination gamut from the plurality of destination gamuts based on a desired output; mapping to the appropriate destination gamut based at least in part on the source gamut boundary; and determining a color conversion lookup table based on the mapping to the appropriate destination gamut for use in replicating the image to provide the desired output using the imaging apparatus.
Abstract:
A method of printing using a plurality of basic colorants and at least one high fidelity colorant includes obtaining system variables that impact high fidelity color printing; and printing with an optimized usage of the plurality of basic colorants and the at least one high fidelity colorant based on a colorant level, wherein a reduced output of the at least one high fidelity colorant will occur if an average colorant level of the at least one high fidelity colorant is lower than an average colorant level of the plurality of basic colorants.
Abstract:
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
Abstract:
An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.