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    APPARATUSES AND METHODS OF OCULAR SURFACE INTERFEROMETRY (OSI) EMPLOYING POLARIZATION AND SUBTRACTION FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM
    11.
    发明申请
    APPARATUSES AND METHODS OF OCULAR SURFACE INTERFEROMETRY (OSI) EMPLOYING POLARIZATION AND SUBTRACTION FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权
    用于成像，处理和/或显示眼睛电影的极化表面干涉（OSI）的装置和方法进行偏振和分离

    公开(公告)号：US20130308095A1

    公开(公告)日：2013-11-21

    申请号：US13870054

    申请日：2013-04-25

    Applicant: TearScience, Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/10

    CPC classification number: A61B3/101 ,  A61B3/0025 ,  G01B11/0675 ,  G06T5/002 ,  G06T5/50 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/20224 ,  G06T2207/30041

    Abstract: Apparatuses and methods employing ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film are disclosed. The apparatuses and methods can be employed for measuring tear film layer thickness (TFLT) of the ocular tear film, which includes lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). An imaging device is focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device is focused on the lipid layer of the tear film to capture a second image containing background signal(s) in the first image. The second image can be subtracted from the first image to reduce and/or eliminate background signal(s) in the first image to produce a resulting image that can be analyzed to measure tear film layer thickness (TFLT).

    Abstract translation: 公开了使用用于成像，处理和/或显示眼泪膜的偏振和减影的眼表面干涉测量（OSI）的装置和方法。 该装置和方法可用于测量眼泪膜的泪膜层厚度（TFLT），其包括脂质层厚度（LLT）和/或水层厚度（ALT）。 成像装置集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。 成像装置聚焦在泪膜的脂质层上，以捕获包含第一图像中的背景信号的第二图像。 可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号，以产生可以被分析以测量泪膜层厚度（TFLT）的所得图像。

    Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film
    12.
    发明授权
    Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film 有权

    公开(公告)号：US11259700B2

    公开(公告)日：2022-03-01

    申请号：US16782384

    申请日：2020-02-05

    Applicant: TearScience, Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

    Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

    Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis
    13.
    发明授权
    Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis 有权

    公开(公告)号：US11141065B2

    公开(公告)日：2021-10-12

    申请号：US16355039

    申请日：2019-03-15

    Applicant: TearScience, Inc.

    Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

    IPC: A61B5/00

    Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

    METHODS AND APPARATUSES FOR TREATMENT OF MEIBOMIAN GLAND DYSFUNCTION
    14.
    发明申请
    METHODS AND APPARATUSES FOR TREATMENT OF MEIBOMIAN GLAND DYSFUNCTION 有权

    公开(公告)号：US20210205131A1

    公开(公告)日：2021-07-08

    申请号：US17208465

    申请日：2021-03-22

    Applicant: TearScience, Inc.

    Inventor： Stephen M. Grenon ,  John Martin Jans ,  Jordan W. Hutchinson ,  Keith Gausmann ,  Donald R. Korb

    IPC: A61F9/007 ,  A61F7/00 ,  A61H7/00 ,  A61F7/12 ,  A61B17/22 ,  A61F7/02

    Abstract: Apparatus and methods for treating dry eye include an energy source configured to apply energy to an obstruction located in a meibomian gland of a patient's eyelid. The apparatus also comprises an insulator configured to be positioned between a rear portion of the patient's eyelid and a surface of the patient's eyeball. An inner surface of the insulator has a curvature greater than that of the patient's eyeball such that an air pocket is formed between the inner surface of the insulator and the patient's eyeball, wherein the air pocket provides additional insulation to reduce or eliminate an amount of heat due to the applied energy from the energy source from being conducted to the surface of the patient's eyeball, such that the applied energy does not cause the temperature to reach a temperature sufficient to cause damage to a corneal or scleral portion of the patient's eyeball.

    Methods and apparatuses for treatment of meibomian glands
    15.
    发明授权
    Methods and apparatuses for treatment of meibomian glands 有权

    公开(公告)号：US10376273B2

    公开(公告)日：2019-08-13

    申请号：US14510863

    申请日：2014-10-09

    Applicant: TearScience, Inc.

    Inventor： Donald R. Korb ,  Timothy R. Willis ,  Stephen M. Grenon

    IPC: A61F7/00 ,  A61F7/02 ,  A61H7/00 ,  A61N7/00 ,  A61B17/22 ,  A61B18/04 ,  A61B18/12 ,  A61F9/007 ,  A61H15/00

    Abstract: Methods and apparatuses of treating meibomian glands are disclosed. The method comprises applying regulated heat to an eyelid to reach a temperature adequate to melt at least one obstruction within at least one meibomian gland. The method also comprises maintaining the regulated heat for a time period adequate to place the at least obstruction in the melted state. The method further comprises positioning a pressure application device into contact with the patient's eyelid and applying a pressure with the pressure application device over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland. An apparatus suitable to treat meibomian glands comprises a heater, a controller, and a pressure applicator configured to be placed into contact with the eyelid and apply a pressure over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland.

    Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
    17.
    发明授权
    Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 有权

    公开(公告)号：US10244939B2

    公开(公告)日：2019-04-02

    申请号：US15995612

    申请日：2018-06-01

    Applicant: TearScience, Inc.

    Inventor： Stephen M. Grenon ,  Donald R. Korb

    IPC: A61B3/00 ,  A61B3/10 ,  A61B3/14 ,  A61B3/107 ,  G02B26/02

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

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