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公开(公告)号：US09555042B2
公开(公告)日：2017-01-31
申请号：US15029269
申请日：2014-10-03
Applicant: University Health Network
Inventor： David W. Hedley , Ines Lohse , Jacqueline M. Mason , Mark R. Bray
IPC: A61K31/5377 , A61K31/416 , A61P35/00 , C07D413/14 , A61K45/06 , A61K31/7068 , A61K33/24
Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明涉及通过施用结构式（I）表示的化合物或其药学上可接受的盐来治疗患有胰腺癌的受试者的方法。
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公开(公告)号：US12286476B2
公开(公告)日：2025-04-29
申请号：US17430311
申请日：2020-02-14
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Richard Brokx , Jacqueline M. Mason , Mark R. Bray
Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
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公开(公告)号：US20230144869A1
公开(公告)日：2023-05-11
申请号：US17917995
申请日：2021-04-12
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Mark R. Bray , Jacqueline M. Mason , Xin Wei , Gordon Duncan
IPC: A61K31/496 , A61P37/06
CPC classification number: A61K31/496 , A61P37/06
Abstract: Disclosed herein is a method of treating a subject with aberrant cytokine release from a disease or condition or at risk of developing aberrant cytokine release from a disease or condition. The method comprises administering to the subject an effective amount of a compound represented by structural formula (I): (I) or a pharmaceutically acceptable salt thereof. The variables in structural formula (I) are as described herein.
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Patent Agency Ranking
公开(公告)号：US20220153834A1
公开(公告)日：2022-05-19
申请号：US17434368
申请日：2020-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Richard Brokx , Jacqueline M. Mason , Mark R. Bray
Abstract: The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
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公开(公告)号：US20220089723A1
公开(公告)日：2022-03-24
申请号：US17421705
申请日：2020-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Richard Brokx , Jacqueline M. Mason , Mark R. Bray
IPC: C07K16/28
Abstract: The invention provides novel anti-LILRB3 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation This invention can also be used to modulate osteoclast differentiation.
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公开(公告)号：US20210261554A1
公开(公告)日：2021-08-26
申请号：US17134270
申请日：2020-12-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Radoslaw Laufer , Grace Ng , Richard Brokx , Heinz W. Pauls , Sze-Wan Li , Jacqueline M. Mason , Mark R. Bray
IPC: C07D487/04 , A61K31/519 , A61K45/06 , A61P37/06 , A61P29/00 , A61P35/00
Abstract: The invention is a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).
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公开(公告)号：US20210060026A1
公开(公告)日：2021-03-04
申请号：US16644633
申请日：2018-09-07
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Jacqueline M. Mason , Mark R. Bray , Tak Wah Mak , Graham Fletcher
IPC: A61K31/5377 , A61K39/395 , A61P35/00
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
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公开(公告)号：US20160250220A1
公开(公告)日：2016-09-01
申请号：US15029269
申请日：2014-10-03
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： David W. Hedley , Ines Lohse , Jacqueline M. Mason , Mark R. Bray
IPC: A61K31/5377 , A61K33/24 , A61K31/7068
CPC classification number: A61K31/5377 , A61K31/7068 , A61K33/24 , A61K45/06 , C07D403/08 , C07D413/14 , A61K2300/00
Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明涉及通过施用结构式（I）表示的化合物或其药学上可接受的盐来治疗患有胰腺癌的受试者的方法。
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