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公开(公告)号：US20070148761A1
公开(公告)日：2007-06-28
申请号：US11705856
申请日：2007-02-13
Applicant: Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Judith Atwood , John Atwood , Susan Stone
Inventor： Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Judith Atwood , John Atwood , Susan Stone
IPC: C12M1/34
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having vials of reaction ingredients. A beam splitter passes an excitation beam to the vials. An emission beam from the reaction ingredients can be passed by the beam splitter to a detector from which a processor can compute DNA concentration. A reference strip with a plurality of reference emitters can be provided which emits reference beams of different intensity, from which the processor can select an optimum emitter for compensating for drift. Exposure time can be automatically adjusted for keeping within optimum dynamic ranges of the detector and processor. A module of the beam splitter and associated optical filters can be associated with a selected dye, and can be replaceable for different dyes.
Abstract translation: 光学仪器在具有小瓶反应成分的反应设备中监测DNA的PCR复制。 分束器将激发光束传递到小瓶。 来自反应成分的发射光束可以通过分光器传递到检测器，处理器可以从该分光器计算DNA浓度。 可以提供具有多个参考发射器的参考条，其发射不同强度的参考光束，处理器可以从其中选择用于补偿漂移的最佳发射器。 曝光时间可以自动调整，以保持在检测器和处理器的最佳动态范围内。 分束器和相关联的滤光器的模块可以与所选择的染料相关联，并且可以替代不同的染料。
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公开(公告)号：US20070102654A1
公开(公告)日：2007-05-10
申请号：US10561079
申请日：2004-06-17
Applicant: Harmannus Franciscus Schoo
Inventor： Harmannus Franciscus Schoo
IPC: G01N21/85
CPC classification number: G01N21/7703 , G01N21/274 , G01N21/4133 , G01N21/43 , G01N21/645 , G01N2021/7786 , G01N2201/0628 , H01L27/288 , H01L51/5036
Abstract: The invention relates to an optical sensor comprising at least one detection module which comprises an organic light emitting diode (1) and an organic detection photodiode (2, 2a) for measuring emitted light which during the use of the sensor reaches the photodiode via the sample holder. Optionally, a sensor according to the invention further comprises a plastic waveguide.
Abstract translation: 本发明涉及一种光学传感器，其包括至少一个检测模块，该检测模块包括有机发光二极管（1）和用于测量发射光的有机检测光电二极管（2,2a），所述发射光在传感器的使用期间经由光电二极管经由 样品架 可选地，根据本发明的传感器还包括塑料波导。
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公开(公告)号：US20060128009A1
公开(公告)日：2006-06-15
申请号：US11333483
申请日：2006-01-17
Applicant: Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Susan Stone , Judith Atwood
Inventor： Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Susan Stone , Judith Atwood
IPC: C12M1/34
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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公开(公告)号：US06995348B2
公开(公告)日：2006-02-07
申请号：US10432296
申请日：2001-10-10
Applicant: Donal Bradley , John De Mello , Andrew De Malio
Inventor： Donal Bradley , John De Mello , Andrew De Malio
IPC: H01L31/00
CPC classification number: G01N21/6454 , G01N21/05 , G01N21/253 , G01N21/31 , G01N2021/0346 , G01N2021/6482 , G01N2201/0628
Abstract: A microfabricated detection system, comprising: a substrate chip; a chamber defined by the substrate chip to which a fluid sample is in use delivered; and at least one detector comprising at least one light-emitting diode including an organic semi-conductor element for emitting light into the chamber and at least one photocell including an organic semiconductor element for receiving light from the chamber.
Abstract translation: 一种微加工检测系统，包括：基板芯片; 由流体样品在其中使用的衬底芯片限定的室; 以及至少一个检测器，包括至少一个发光二极管，所述发光二极管包括用于将光发射到所述腔室中的有机半导体元件和至少一个包含用于接收来自所述腔室的光的有机半导体元件的光电池。
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15.发明申请公开(公告)号：US20050036142A1
公开(公告)日：2005-02-17
申请号：US10887528
申请日：2004-07-08
Applicant: Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
Inventor： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
CPC classification number: G01N21/6456 , B82Y10/00 , B82Y20/00 , G01N27/44721 , G01N2021/6417 , G01N2021/6419 , G01N2021/6471 , G01N2201/0628
Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.
Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。
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Patent Agency Ranking
公开(公告)号：US20030148505A1
公开(公告)日：2003-08-07
申请号：US10370846
申请日：2003-02-20
Inventor： Michael R. Gambini , John G. Atwood , Susan Atwood Stone , Judith K. Atwood , Eugene F. Young , Edward J. Lakatos , Anthony L. Cerrone
IPC: C12M001/34
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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17.发明申请公开(公告)号：US20190234877A1
公开(公告)日：2019-08-01
申请号：US16311647
申请日：2017-06-09
Inventor： Jonathan Behrendt
CPC classification number: G01N21/6428 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , C12Q1/26 , C12Y101/0304 , C12Y107/99004 , G01N21/77 , G01N33/182 , G01N2021/1765 , G01N2021/6439 , G01N2021/7786 , G01N2201/0628
Abstract: A method of testing a sample for the presence of nitrate or nitrite, the method comprising the steps of: forming a mixture by contacting the sample with a composition comprising hydrogen peroxide or a hydrogen peroxide precursor and a fluorescent indicator precursor capable of forming a fluorescent indicator in the presence of peroxynitrite; irradiating the mixture; and measuring fluorescence from the fluorescent indicator. The method may be carried out using a device in which the mixture in a channel or chamber 101 of a microfluidic device is irradiated by light from light source 103 and emission from the fluorescent indicator is detected by photodetector 105.
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公开(公告)号：US20180231464A1
公开(公告)日：2018-08-16
申请号：US15751074
申请日：2016-08-19
Applicant: Molecular Vision Limited
Inventor： Chris Hand , Oliver Hofmann , Gihan Ryu , Miguel Ramon , Dene Baldwin
IPC: G01N21/64 , G01N21/84 , G01N33/558 , G01N21/78
CPC classification number: G01N21/645 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N33/558 , G01N2021/6439 , G01N2021/7786 , G01N2201/0628
Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action. The lateral flow membrane (4) comprises at least one test region (8, 12) comprising an immobilised second assay component for retaining the tagging particles in the test region (8, 12) in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region (8, 12) that is indicative of the concentration of the analyte in the liquid sample. The emitter (2) comprises an emission layer (9, 16) of an organic electroluminescent material and the emission layer (9, 16) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the emitter (2) is capable of illuminating the test region (8, 12). The detector (3) comprises an absorption layer (10, 15) of an organic photovoltaic material and the absorption layer (10, 15) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the detector (3) is capable of detecting light from the test region (8, 12).
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19.发明申请公开(公告)号：US20170248463A1
公开(公告)日：2017-08-31
申请号：US15329096
申请日：2015-07-10
Inventor： Norbert DANZ , Christoph WAECHTER
CPC classification number: G01J1/4228 , G01J3/10 , G01J3/42 , G01J3/505 , G01J2001/4252 , G01N21/553 , G01N2201/0628 , H01L33/105 , H01L33/58 , H01L51/5036 , H01L51/5265 , H01L51/5275
Abstract: The invention relates to an arrangement for a spatially resolved and wavelength-resolved detection of light radiation emitted from at least one OLED or LED. A multilayer system is arranged between an electrode, an OLED or an LED, and a substrate and is formed using layers formed alternately above one another from a material having higher and lower optical refractive indices n. In this respect, light radiation from the at least one OLED or LED and having a plurality of different wavelengths λ1, λ2, λ3, . . . λn thus exits the multilayer system. Light radiation that exits at different wavelengths λ1, λ2, λ3, . . . λn at different angles is incident onto at least one detector array after at least a simple refraction at an optical element or after reflection at a layer or at a layer system of a sensor such that light radiation at a wavelength λ1, λ2, λ3, . . . or λn is incident onto a respective detector element of the detector array. The detector elements of the detector array are arranged discretely from one another.
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公开(公告)号：US09651482B2
公开(公告)日：2017-05-16
申请号：US14783170
申请日：2014-04-16
Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
Inventor： Gertrud Blei , Mario Bock
CPC classification number: G01N21/4738 , A61M5/31 , A61M5/3155 , A61M5/31568 , A61M2005/3126 , A61M2205/3306 , A61M2205/3379 , A61M2205/3553 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/6081 , A61M2205/8206 , A61M2209/04 , G01N2201/021 , G01N2201/0628 , G01N2201/0634 , G06F19/00 , G06F19/3468
Abstract: A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device having an OLED having a transparent first electrode, a transparent second electrode and a central layer disposed between the first and second electrodes, the central layer comprising at least one organic layer, the at least one organic layer configured to emit light through the transparent first electrode, and an optical sensor arranged to receive light reflected from a surface of the drug delivery device, wherein the central layer of the OLED has a region without the at least one organic layer and wherein the optical sensor is arranged, when the sensor device is attached to the drug delivery device, to view a predetermined area of the surface of the drug delivery device through the region without the at least one organic layer.
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