公开(公告)号：US09719917B2

公开(公告)日：2017-08-01

申请号：US13130166

申请日：2009-11-23

Applicant: Hakan Frojdh ,  Mikael Hornqvist ,  Stig Tormod ,  Patrik Akerstrom

Inventor： Hakan Frojdh ,  Mikael Hornqvist ,  Stig Tormod ,  Patrik Akerstrom

IPC: G01N21/61 ,  G01N21/33 ,  G01N21/05 ,  G01N21/51 ,  G01J3/02 ,  G01J3/433 ,  G01N21/03

CPC classification number: G01N21/33 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/433 ,  G01N21/05 ,  G01N21/51 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/0853 ,  G01N2201/086

Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

公开(公告)号：US20110133101A1

公开(公告)日：2011-06-09

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G01J1/58 ,  G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US20090097806A1

公开(公告)日：2009-04-16

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US07289204B2

公开(公告)日：2007-10-30

申请号：US10476425

申请日：2002-05-02

Applicant: Hans Ole Nielsen ,  Jan H. Hansen ,  Kim P. Hansen

Inventor： Hans Ole Nielsen ,  Jan H. Hansen ,  Kim P. Hansen

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2201/086

Abstract: An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (3) and being adapted to receive one or more excitation signals (1a), to produce reference optical signals (6b) in response thereto, and to produce one or more electrical reference output signals (7b) in response to one or more excitation signals (1a); and (d) or more phase detectors (10), said phase detections being adapted to detect one or more delays of said one or more electrical output signals of said one or more fluorescence sensor systems and said one or more reference systems, and to produce one or more phase output signals; and a method of measuring concentration of one or more analytes using such apparatus and/or devices.

Abstract translation: 一种用于测量一种或多种分析物的荧光传感器的荧光寿命的装置和装置，所述装置包括（c）一个或多个参考系统（3,6,7），所述参考系统各自包括一个或多个参考光源（3） 并且适于接收一个或多个激励信号（1a）以响应于此产生参考光信号（6b），并响应于一个或多个激励信号产生一个或多个电参考输出信号（7b） （1 a）; 和（d）或更多相位检测器（10），所述相位检测器适于检测所述一个或多个荧光传感器系统和所述一个或多个参考系统的所述一个或多个电输出信号的一个或多个延迟，并且产生 一个或多个相位输出信号; 以及使用这种装置和/或装置测量一种或多种分析物的浓度的方法。

公开(公告)号：US5994707A

公开(公告)日：1999-11-30

申请号：US819050

申请日：1997-03-18

Applicant: Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

Inventor： Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/086

Abstract: A low cost portable fiber optic fluorometer is packaged as a personal computer peripheral and is based on interchangeable modules. One embodiment of the fluorometer comprises an excitation source, a detector, a signal processor, frequency source, wavelength selector, and an optical interface. The optical interface is exclusively fiber optic-based, thereby simplifying optical alignment and reducing the cost of the fluorometer. In another embodiment, the excitation source is an inexpensive monochromatic excitation source. In this case, the monochromatic excitation source and the first wavelength selector are preferably removable and replaceable, so that the fluorometer is advantageously able to generate different excitation wavelengths and detect different emission wavelengths. A fluorescence measurement method comprises the steps of generating an excitation signal; transmitting the excitation signal to a system under study which, in response, generates an emission signal; and detecting both the excitation signal and the emission signal with the fluorometer, and then using the detected excitation signal as a reference signal to calibrate the fluorometer and to nullify distortion errors in the emission signal. The use of the excitation signal as a reference signal provides an advantageously simple way to calibrate the fluorometer and to nullify distortion errors in the emission signal. An alternative method allows the precise shapes of the emission signal and the excitation signal to be profiled. The fluorometry method and apparatus can both advantageously be used for performing both direct fluorescence lifetime measurements and for performing phase fluorometry.

Abstract translation: 低成本便携式光纤荧光计作为个人计算机外围设备封装，并且基于可互换的模块。 荧光计的一个实施例包括激发源，检测器，信号处理器，频率源，波长选择器和光学接口。 光接口仅仅是基于光纤的，从而简化了光学对准并降低了荧光计的成本。 在另一个实施例中，激发源是便宜的单色激发源。 在这种情况下，单色激发源和第一波长选择器优选是可移除和可更换的，使得荧光计有利地能够产生不同的激发波长并检测不同的发射波长。 荧光测量方法包括产生激励信号的步骤; 将激励信号传输到被研究的系统，其响应地产生发射信号; 并用荧光计检测激发信号和发射信号，然后使用检测到的激发信号作为参考信号来校准荧光计，并消除发射信号中的失真误差。 使用激励信号作为参考信号提供校准荧光计并消除发射信号中的失真误差的有利的简单方式。 替代方法允许对发射信号和激励信号的精确形状进行轮廓分析。 荧光测定方法和装置可以有利地用于进行直接荧光寿命测量和用于进行相位荧光测定。

公开(公告)号：US5287168A

公开(公告)日：1994-02-15

申请号：US72668

申请日：1993-06-07

Applicant: David Poucher ,  Chilengi Madhusudhan ,  Joaquin M. Otero

Inventor： David Poucher ,  Chilengi Madhusudhan ,  Joaquin M. Otero

IPC: G01N21/27 ,  G01N21/59 ,  G01N21/85 ,  G01N21/53 ,  G01N21/09

CPC classification number: G01N21/8507 ,  G01N2201/086 ,  G01N2201/0866

Abstract: The sensor system monitors solutes in a liquid stream by analyzing the amount of light absorbed in a liquid in a particular wavelength band. The sensor system is arranged for selectability of the type of fiber used for transmission and adjustability of the liquid gap length in the liquid so that individual installations can be arranged with optimum characteristics for sensing particular chemical species in solution by absorption spectroscopy.

Abstract translation: 传感器系统通过分析在特定波长带中的液体中吸收的光量来监测液体流中的溶质。 传感器系统被布置用于可选择性的用于传输的纤维类型和液体间隙长度在液体中的可调节性，使得各个装置可以布置成具有用于通过吸收光谱检测溶液中的特定化学物质的最佳特性。

公开(公告)号：US12117389B2

公开(公告)日：2024-10-15

申请号：US17487722

申请日：2021-09-28

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/36 ,  G02B6/38 ,  G02B6/42

CPC classification number: G01N21/05 ,  G02B6/3616 ,  G02B6/3644 ,  G02B6/3825 ,  G02B6/3861 ,  G02B6/4219 ,  G01N2021/052 ,  G01N2201/0664 ,  G01N2201/0668 ,  G01N2201/0813 ,  G01N2201/086 ,  G02B6/36

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.

公开(公告)号：US20240142384A1

公开(公告)日：2024-05-02

申请号：US18493952

申请日：2023-10-25

Applicant: Exner & Tottewitz Besitz GbR

Inventor： Michael Tottewitz ,  Detlef Exner ,  Gabriel Cremers ,  Yasar Güney

IPC: G01N21/85

CPC classification number: G01N21/8507 ,  G01N2201/086 ,  G01N2201/088

Abstract: A sensor positioning device, having a holding module, with a sensor receptacle, fastening element and spring element, the sensor receptacle being mounted movably relative to the fastening element along a compensating axis. The spring is arranged between the fastening element and the sensor receptacle to cooperate therewith, to create a restoring force during movement of the receptacle relative to the fastening element. A measurement connector with an abutment is configured for arrangement onto a process container, and is configured for releasable arrangement on the holding module. The sensor positioning device is configured such that, when the measurement connector is arranged on the holding module, the sensor receptacle is movable relative to the fastening element along the axis, and a pressing force of the sensor receptacle onto the abutment of the measurement connector is created by the spring. A sensor unit, for turbidity measurement, is provided having the sensor positioning device.

公开(公告)号：US20160266043A1

公开(公告)日：2016-09-15

申请号：US14394445

申请日：2014-09-01

Applicant: VYSOKÉ UCENI TECHNICKÉ V BRNE

Inventor： Jan NOVOTNÝ ,  Jozef KAISER ,  Jan PROCEK ,  Michal BRADA ,  Michal PETRILAK ,  Ivan KRUPKA

IPC: G01N21/71 ,  G01N21/17

CPC classification number: G01N21/718 ,  G01N21/17 ,  G01N2021/1793 ,  G01N2201/024 ,  G01N2201/086

Abstract: A modular device for remote chemical material analysis with a basic function unit which is formed with a transport module, which is partly equipped with a mobile frame construction which is set up with at least a power supply of the laser, a detection system, designed for plasma radiation dispersion according to the wavelength and its record, a control and evaluation block in the form of PC and a control electronic block and partly is connected with a laser module which contains a laser head, which serves as a source of laser pulses, where the essence of the invention is that the laser module is equipped with a laser beam router of optional routing of laser pulses either into a stand-off module when analyzed with a “Stand-Off LIBS” method or into a fiber module when analyzed with a “Remote LIBS” method.

Abstract translation: 一种用于远程化学物质分析的模块化装置，具有基本功能单元，该基本功能单元形成有传送模块，其部分地配备有至少设置有激光器的电源的移动框架结构，设计用于 根据波长及其记录的等离子体辐射色散，以PC和控制电子块的形式的控制和评估块，并且部分地与包含用作激光脉冲源的激光头的激光模块连接，其中激光头 本发明的实质是激光模块配备有激光束路由器，其可选地将激光脉冲路由到分立模块中，当用“Stand-off LIBS”方法分析时，或者当用 “远程LIBS”方法。

公开(公告)号：US20160266039A1

公开(公告)日：2016-09-15

申请号：US15042354

申请日：2016-02-12

Applicant: Yokogawa Electric Corporation

Inventor： Yasuyuki SUZUKI ,  Yukihiro NAKAMURA ,  Tetsushi NAMATAME

IPC: G01N21/59 ,  G02B17/00 ,  G01N21/01

CPC classification number: G01N21/59 ,  G01N21/8507 ,  G01N2021/0307 ,  G01N2201/0637 ,  G01N2201/08 ,  G01N2201/086 ,  G02B17/006

Abstract: An optical element includes a main body formed of a light transmissive material and including an arc-shaped optical path, and a gap formed on the arc-shaped optical path in the main body. The gap may have a notch shape. The main body may have a semicircular plate shape. The main body may have a hemispherical shape.

Abstract translation: 光学元件包括由透光材料形成并包括弧形光路的主体以及形成在主体中的弧形光路上的间隙。 间隙可以具有凹口形状。 主体可以具有半圆形板形状。 主体可以具有半球形。