公开(公告)号：US20250109377A1

公开(公告)日：2025-04-03

申请号：US18728767

申请日：2023-02-13

Applicant: THE UNIVERSITY OF MASSACHUSETTS

Inventor： Seongkyu Yoon ,  Bingyu Kuang ,  Duc Hoang

IPC: C12N5/00 ,  C12N5/071 ,  G01J3/44 ,  G01N30/02 ,  G01N30/72

Abstract: A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite below an inhibitory concentration in the cell culture medium for the at least one metabolite, wherein the at least one metabolite is aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI), N-acetylputrescinium (NAP), or a combination thereof, and wherein the enzyme comprises ADH5, BCAT1, CAT, GOT1, HADHB, HOGA1, SLC35A1, or a combination thereof.

公开(公告)号：US12264966B2

公开(公告)日：2025-04-01

申请号：US18562332

申请日：2023-04-06

Applicant: NANJING NUOYUAN MEDICAL DEVICES CO., LTD.

Inventor： Huiming Cai ,  Ziyang Wang

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/28 ,  G01J3/12

Abstract: Provided are a fluorescence imaging probe and a handheld imaging prober, relating to the technical field of medical devices. The fluorescence imaging probe includes a dichroic filter and an image detector, the dichroic filter is arranged at an included angle of 45° with a direction of a main optical axis of incident excitation light, the incident excitation light is reflected by the dichroic filter to a target detection position, the reflected incident excitation light excites a fluorescent substance at the target detection position to form fluorescence, a main optical axis of the fluorescence is arranged coaxially with the image detector, the fluorescence is incident to the image detectors through the dichroic filter, and the image detector converts the received fluorescence into an image signal.

公开(公告)号：US20250093203A1

公开(公告)日：2025-03-20

申请号：US18969532

申请日：2024-12-05

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N33/52 ,  G01N33/68

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for measuring a sample collected from a subject comprises a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate, wherein a sample collected from a subject is configured to be disposed on the NAAO substrate; wherein the laser beam is configured to be incident on the sample on the NAAO substrate, and a light signal is produced in response to the laser beam; and a light sensor configured to receive the light signal, wherein the laser generator, the NAAO substrate, and the light sensor are disposed on a base having a top surface, wherein the top surface has an area of less than 200 cm2.

公开(公告)号：US12247879B2

公开(公告)日：2025-03-11

申请号：US18434658

申请日：2024-02-06

Applicant: Samsung Electronics Co., Ltd.

Inventor： Radwanul Hasan Siddique ,  Daniel Assumpcao ,  Hyuck Choo ,  Hyochul Kim

IPC: G01J3/18 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44

Abstract: Optical spectrometers may be used to determine the spectral components of electromagnetic waves. Spectrometers may be large, bulky devices and may require waves to enter at a nearly direct angle of incidence in order to record a measurement. What is disclosed is an ultra-compact spectrometer with nanophotonic components as light dispersion technology. Nanophotonic components may contain metasurfaces and Bragg filters. Each metasurface may contain light scattering nanostructures that may be randomized to create a large input angle, and the Bragg filter may result in the light dispersion independent of the input angle. The spectrometer may be capable of handling about 200 nm bandwidth. The ultra-compact spectrometer may be able to read image data in the visible (400-600 nm) and to read spectral data in the near-infrared (700-900 nm) wavelength range. The surface area of the spectrometer may be about 1 mm2, allowing it to fit on mobile devices.

公开(公告)号：US12228520B2

公开(公告)日：2025-02-18

申请号：US18516429

申请日：2023-11-21

Applicant: Jonathan David Waldern

Inventor： Jonathan David Waldern

IPC: G01J3/44 ,  G01N21/65 ,  G02B1/00

Abstract: A general purpose sensor architecture integrating a surface enhanced Raman spectroscopy (SERS) substrate, a diffractive laser beam delivery substrate and a diffractive infrared detection substrate is provided that can be used to implement a low-cost, compact lab-on-a-chip biosensor that can meet the needs of large-scale infectious disease testing. The sensor architecture can also be used in any other application in which molecules present in the liquid, gaseous or solid phases need to be characterized reliably, cost-effectively and with minimal intervention by highly skilled personnel.

公开(公告)号：US12209908B2

公开(公告)日：2025-01-28

申请号：US17802340

申请日：2021-02-25

Applicant: HORIBA FRANCE SAS

Inventor： Sébastien Laden ,  Alexandre Kokota

IPC: G01J3/44 ,  G01J3/28

Abstract: Disclosed is a method of acquiring and forming a spectrometry image of a sample including the following steps: e1) acquisition of an initial image, composed of pixels, of an area of the sample and definition of a maximum set of N, 2≤N, measurement positions of spectrometry, each measurement position including a coordinate and an intensity determined on the basis of the pixels; e2) assignment of a classification value to each of the N measurement positions on the basis of deviations, calculated based on an intensity difference and a coordinate difference, between the measurement positions; e3) determination of a group of P, 1≤P≤N, measurement positions as a function of the classification values; e4) successively, for each measurement position of the group, positioning of an excitation beam in the measurement position on the area of the sample, acquisition of a spectrometry measurement and formation of the spectrometry image.

公开(公告)号：US20240410756A1

公开(公告)日：2024-12-12

申请号：US18485756

申请日：2023-10-12

Applicant: TOP TECHNOLOGY PLATFORM CO., LTD.

Inventor： YU NIEN LU ,  FENG-MIN SHEN

IPC: G01J3/44 ,  G01N21/65

Abstract: A proposed Raman measurement device has a housing, an optical module, and a measuring probe. The measuring probe is connected to the optical module which is installed in the housing. A part of the measuring probe protrudes from the housing. An open end of the measuring probe outputs an emitted light from a laser light source in the optical module and receives the Raman scattered light excited from a surface to be detected. The axial centerline of the measuring probe and any parallel line in the length direction of the housing include an angle of 15° to 50° and the effective focusing distance between the open end of the measuring probe and the surface to be detected is 7 mm to 9 mm.

公开(公告)号：US20240410750A1

公开(公告)日：2024-12-12

申请号：US18406823

申请日：2024-01-08

Applicant: Metrohm Spectro, Inc. (d/b/a Metrohm Raman)

Inventor： Danial Clark BARKHURST ,  Sean Patrick Woodward ,  Keith Thompson Carron ,  Shane Alan Buller

IPC: G01J3/02 ,  G01J3/44 ,  G02B7/182

Abstract: Optical systems have uses, such as in spectrometers, for directing a beam. A spectrometer, for example, utilizes an optical system for directing an incident beam toward a sample and receiving a spectroscopy signal from the sample. In various implementations, for example, an optical system may be further configured to move a beam with respect to a target, such as a sample, and still provide a home position where the beam is directed in a stationary configuration. A self-homing (e.g., self-centering) optical system may provide a “home” position in which the beam is directed in a first stationary mode while still allowing a focused beam to be moved with respect to a target in a second dynamic mode.

公开(公告)号：US12152991B2

公开(公告)日：2024-11-26

申请号：US17870090

申请日：2022-07-21

Applicant: Cedars-Sinai Medical Center

Inventor： Pramod Butte ,  Paul Lapchak ,  David Scott Kittle

IPC: G01N21/64 ,  A61B5/00 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  A61B5/1455 ,  A61B5/1459

Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.

公开(公告)号：US20240385033A1

公开(公告)日：2024-11-21

申请号：US18689525

申请日：2022-08-30

Applicant: Siemens Aktiengesellschaft

Inventor： Konstantin HAAR ,  Camiel HEFFELS

IPC: G01J1/04 ,  G01J3/44 ,  G01N21/65

Abstract: An analysis unit, a computer program product and a Raman photometer that includes a base module having a measuring cell that generates Raman radiation that is emitted through a substance sample and includes at least one expansion module having at least a first semi-permeable interference filter used to simultaneously detect a first and second components of the substance sample, where a corresponding method for measuring the composition of the substance sample is implemented via the Raman photometer, and where an analysis unit is configured to perform the method, and to a spectrometer system which comprises a Raman photometer according to the invention.