公开(公告)号：US20160061808A1

公开(公告)日：2016-03-03

申请号：US14491158

申请日：2014-09-19

Applicant: Synaptive Medical (Barbados) Inc.

Inventor： Aaron Cheung ,  Siu Wai Jacky Mak ,  Michael Wood ,  Cameron Piron

IPC: G01N33/483 ,  A61B10/02 ,  G01N21/27 ,  G01N21/65 ,  G01N21/47

CPC classification number: G01N1/286 ,  A61B5/0075 ,  A61B5/4064 ,  A61B5/4836 ,  A61B10/0266 ,  G01N1/08 ,  G01N1/31 ,  G01N21/65 ,  G01N33/4833 ,  G01N2201/06113 ,  G01N2201/0826

Abstract: The present invention provides a method and system for identification and isolation of cells from tissues using optical spectroscopy. The method includes accessing the cells using an access corridor, measuring the cells using optical spectroscopy, comparing the spectra of the cells to signature spectra, using the comparison to identify the cells and removing the cells into a container. The system includes an access corridor, a probe for measuring the cells, a resection tool, a collection tube and a collection container.

Abstract translation: 本发明提供一种使用光谱鉴定和分离细胞从组织中分离的方法和系统。 该方法包括使用存取走廊访问细胞，使用光谱法测量细胞，将细胞的光谱与特征谱进行比较，使用比较来鉴定细胞并将细胞移入容器中。 该系统包括通道走廊，用于测量细胞的探针，切除工具，收集管和收集容器。

公开(公告)号：US20160033395A1

公开(公告)日：2016-02-04

申请号：US14449511

申请日：2014-08-01

Applicant: INSTITUT NATIONAL D'OPTIQUE

Inventor： Francois Babin

IPC: G01N21/27 ,  G01N21/25

CPC classification number: G01N21/274 ,  G01N21/7703 ,  G01N21/78 ,  G01N21/80 ,  G01N2021/7709 ,  G01N2021/772 ,  G01N2021/7793 ,  G01N2201/0612 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/084 ,  G01N2201/088

Abstract: An optical system for sensing an environmental parameter, comprising: a pulse generator for generating a first pulse having a first wavelength and a second pulse having a second wavelength; a pulse splitter for splitting each one of the first and second pulse into a sensing pulse and a reference pulse; a sensing arm for receiving the sensing pulses therefrom and comprising a spectro-ratiometric sensor; a reference arm for receiving the reference pulses; a time delay line for delaying a relative propagation of the sensing pulses and the reference pulses; a light detector for measuring an optical energy of the sensing pulse and the reference pulse, for the first and second wavelengths; and at least one optical link for optically connecting the pulse generator to the pulse splitter, and the sensing and reference arms to the light detector.

Abstract translation: 一种用于感测环境参数的光学系统，包括：脉冲发生器，用于产生具有第一波长的第一脉冲和具有第二波长的第二脉冲; 用于将第一和第二脉冲中的每一个分成感测脉冲和参考脉冲的脉冲分离器; 用于从其接收感测脉冲并包括光谱比例传感器的感测臂; 用于接收参考脉冲的参考臂; 用于延迟感测脉冲和参考脉冲的相对传播的延时线; 光检测器，用于测量第一和第二波长的感测脉冲和参考脉冲的光能; 以及用于将脉冲发生器光学地连接到脉冲分离器的至少一个光学链路，以及用于光检测器的感测和参考臂。

公开(公告)号：US20160011100A1

公开(公告)日：2016-01-14

申请号：US14796007

申请日：2015-07-10

Applicant: Airbus Operations Limited

Inventor： Alessio Cipullo ,  Franklin Tichborne ,  Joseph K-W Lam ,  David Kilvington

IPC: G01N21/31 ,  G01N21/25 ,  G01N33/22

CPC classification number: G01N21/31 ,  B64D37/005 ,  G01F22/00 ,  G01F23/292 ,  G01N21/255 ,  G01N21/8507 ,  G01N21/94 ,  G01N33/22 ,  G01N33/2835 ,  G01N2021/8528 ,  G01N2201/061 ,  G01N2201/08 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A probe for determining a characteristic of the contents in a fuel tank. The probe includes at least one analysis element. The or each analysis element has an input for inputting light to a sampling region to be analysed and an output for outputting light that has passed through the sampling region from the input. A system including a probe and a spectrometer is also provided.

Abstract translation: 用于确定燃料箱中的内容物的特性的探针。 探针包括至少一个分析元件。 该分析元件或每个分析元件具有用于将光输入到要分析的采样区域的输入和用于输出已经从输入通过采样区域的光的输出。 还提供了包括探针和光谱仪的系统。

公开(公告)号：US20150168295A1

公开(公告)日：2015-06-18

申请号：US14406638

申请日：2013-06-07

Applicant: PURAC BIOCHEM BV

Inventor： Gerrit Gobius Du Sart ,  Vincent De Jong ,  Jan Arie Niessen

IPC: G01N21/3563 ,  G01N21/359

CPC classification number: G01N21/3563 ,  C08G63/08 ,  C08L67/04 ,  G01N21/3577 ,  G01N21/359 ,  G01N2021/8411 ,  G01N2021/8416 ,  G01N2201/061 ,  G01N2201/0826

Abstract: The present invention relates to a method for quantification of the amount of lactide in a lactide-based polymeric matrix by means of Infra Red Spectroscopy measurement. According to the invention the quantification is based on measurements performed on absorptions in the near Infra Red region of the electromagnetic spectrum. The invented method allows a rapid, easy and cheap quantification of lactide in a polymeric matrix, especially in PLA.

Abstract translation: 本发明涉及一种通过红外光谱法测量丙交酯型聚合物基质中丙交酯量的方法。 根据本发明，定量是基于对电磁光谱的近红外区域的吸收进行的测量。 本发明的方法允许在聚合物基质中，特别是在PLA中快速，容易和便宜地定量丙交酯。

公开(公告)号：US20150140645A1

公开(公告)日：2015-05-21

申请号：US14486987

申请日：2014-09-15

Applicant: STOKES BIO LIMITED

Inventor： Mark Davies ,  Tara Dalton

IPC: B01L7/00

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/6428 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A thermal cycling device (3) device a number of fixed thermal zones (11, 12, 13) and a fixed conduit (10) passing through the thermal zones. A controller maintains each thermal zone including its section of conduit (10) at a constant temperature. A series of droplets flows through the conduit (10) so that each droplet is thermally cycled, and a detection system detects fluorescence from droplets at all of the thermal cycles. The conduit is in a single plane, and so a number of thermal cycling devices may be arranged together to achieve parallelism. The flow conduit comprises a channel (17) and a capillary tube (10) inserted into the channel. The detection system may perform scans along a direction to detect radiation from a plurality of cycles in a pass.

Abstract translation: 热循环装置（3）装置设有多个固定热区（11,12,13）和通过热区的固定导管（10）。 控制器将每个热区域保持在其恒定温度下的导管（10）部分。 一系列液滴流过导管（10），使得每个液滴热循环，并且检测系统在所有热循环中检测来自液滴的荧光。 导管处于单个平面中，因此可以将多个热循环装置布置在一起以实现平行。 流动管道包括插入通道中的通道（17）和毛细管（10）。 检测系统可以沿着一个方向执行扫描，以检测通过中多个周期的辐射。

公开(公告)号：US09019502B1

公开(公告)日：2015-04-28

申请号：US14335149

申请日：2014-07-18

Applicant: U.S. Department of Energy

Inventor： Paul R. Ohodnicki, Jr. ,  Andrew M. Schultz

IPC: G01N21/00 ,  G01N21/55 ,  G01N21/78

CPC classification number: G01N21/783 ,  G01N2201/0826

Abstract: The disclosure relates to a method of detecting a change in a chemical composition by contacting a electronically conducting perovskite-based metal oxide material with a monitored stream, illuminating the electronically conducting perovskite-based metal oxide with incident light, collecting exiting light, monitoring an optical signal based on a comparison of the incident light and the exiting light, and detecting a shift in the optical signal. The electronically conducting perovskite-based metal oxide has a perovskite-based crystal structure and an electronic conductivity of at least 10−1 S/cm, where parameters are specified at the gas stream temperature. The electronically conducting perovskite-based metal oxide has an empirical formula AxByO3-δ, where A is at least a first element at the A-site, B is at least a second element at the B-site, and where 0.8

Abstract translation: 本公开涉及一种通过使电子导电的钙钛矿型金属氧化物材料与监测的流体接触来检测化学组成的变化的方法，用入射光照射电子导电的钙钛矿型金属氧化物，收集离开的光，监测光学 基于入射光和出射光的比较的信号，并检测光信号的偏移。 电子导电钙钛矿型金属氧化物具有至少10-1S / cm的钙钛矿型晶体结构和电子导电性，其中在气流温度下规定了参数。 电子导电钙钛矿型金属氧化物具有经验式AxByO3-δ，其中A至少为A位的第一元素，B为B位上的至少第二元素，其中0.8

公开(公告)号：US20150045636A1

公开(公告)日：2015-02-12

申请号：US13963925

申请日：2013-08-09

Applicant: Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

Inventor： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC classification number: G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

Abstract translation: 使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20140357998A1

公开(公告)日：2014-12-04

申请号：US14361428

申请日：2012-11-09

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Toshihiko Suzuki ,  Yutaka Yamashita ,  Yukio Ueda ,  Etsuko Yamaki ,  Daisuke Yamashita ,  Kenji Yoshimoto ,  Harumi Sakahara ,  Hiroyuki Ogura ,  Hatsuko Nasu

IPC: A61B5/00 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61B5/0091 ,  A61B5/0035 ,  A61B5/708 ,  A61B8/0825 ,  A61B8/4416 ,  A61B2562/046 ,  A61B2562/146 ,  A61B2562/168 ,  G01N21/4795 ,  G01N2021/4797 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.

Abstract translation: 公开了一种乳房摄影装置。 乳房摄影装置包括构造成围绕乳房的容器和附接到容器中的内部的多个光纤，并被配置为执行辐射和光的检测。 该容器具有一个具有一个开口的基座构件，多个环形构件连续地设置成与该开口连通，一个底部构件设置在与基座构件间隔最远的环形构件内部。 环形构件和底部构件被构造成在连通方向上相对地移动基部构件或基底构件侧的相邻环形构件。 多个光纤中的一些被附接到多个环形构件。

公开(公告)号：US08817257B2

公开(公告)日：2014-08-26

申请号：US13714807

申请日：2012-12-14

Applicant: Commissariat a l'energie atomique et aux energies alternatives

Inventor： Lionel Herve

IPC: G01N21/59 ,  G01N21/64 ,  G06T11/00 ,  G01N21/47 ,  G01N21/49 ,  G01N21/17 ,  A61B5/00 ,  G09B23/28

CPC classification number: G01N21/59 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/4064 ,  A61B5/4255 ,  A61B5/4312 ,  A61B5/4381 ,  A61B5/7253 ,  G01N21/4795 ,  G01N21/49 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/6413 ,  G01N2021/6484 ,  G01N2201/0697 ,  G01N2201/0826 ,  G01N2201/0833 ,  G06T11/003 ,  G09B23/286

Abstract: A method reconstructing the optical properties of a medium using a reconstruction system has a radiation source lighting the medium and a detector receiving a signal transmitted by the medium. The steps include lighting the medium using a radiation source, receiving by the detector of a signal emitted by the medium, and processing, for a source-detector pair, of a first distribution of the signal received by the corresponding detector. Then computing the Mellin-Laplace transform, for a given order and a given variable, of a magnitude comprising the first distribution, the order being an integer, the variable being a real number, and reconstructing optical properties of the medium using the Mellin-Laplace transform of said magnitude. The computation step includes computing a plurality of Mellin-Laplace transforms of the magnitude for distinct values of the order, and the reconstruction step is carried out from a combination of the plurality of Mellin-Laplace transforms.

Abstract translation: 使用重建系统重建介质的光学特性的方法具有照射介质的辐射源和接收由介质传输的信号的检测器。 这些步骤包括使用辐射源照亮介质，由检测器接收由介质发射的信号，以及对源检测器对处理由相应的检测器接收的信号的第一分布。 然后，对于给定的顺序和给定的变量，计算包含第一分布的幅度的Mellin-Laplace变换，该顺序是整数，该变量是实数，并使用Mellin-Laplace重建介质的光学性质 转换所述幅度。 所述计算步骤包括计算所述次序的不同值的幅度的多个Mellin-Laplace变换，并且所述重建步骤是从所述多个Mellin-Laplace变换的组合中执行的。

公开(公告)号：US08755866B2

公开(公告)日：2014-06-17

申请号：US11381443

申请日：2006-05-03

Applicant: John F. Heanue ,  Joseph A. Heanue ,  Brian P. Wilfley ,  Augustus P. Lowell

Inventor： John F. Heanue ,  Joseph A. Heanue ,  Brian P. Wilfley ,  Augustus P. Lowell

IPC: A61B6/00

CPC classification number: A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and method for optical lymph node mapping. The system is useful for guiding sentinel lymph node biopsy surgeries. A contrast agent that includes a fluorescent dye is injected near the site of a malignancy. The contrast agent drains into the lymphatic system, collecting in a sentinel node or nodes. The system utilizes one or more low-power continuous-wave lasers or light-emitting diodes modulated with a digital code sequence to probe the tissue suspected of containing the sentinel node. When the light is incident near the sentinel node, it will excite fluorescence from the dye. A portion of the scattered fluorescent light is captured with one or more photo-detectors. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. The flight time distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.

Abstract translation: 一种用于光学淋巴结图谱的系统和方法。 该系统可用于引导前哨淋巴结活检。 包含荧光染料的造影剂在恶性肿瘤部位附近注射。 造影剂排入淋巴系统，收集在前哨节点或节点。 该系统利用一个或多个低功率连续波激光器或用数字代码序列调制的发光二极管来探测怀疑含有前哨节点的组织。 当光在哨兵节点附近入射时，它会激发染料的荧光。 一部分散射的荧光被一个或多个光电探测器捕获。 计算光检测器信号和数字码序列的相关性，以产生从给定源到给定检测器的光子的飞行时间分布的估计。 飞行时间分布与测量的振幅一起使用以重建组织内造影剂位置的图。