公开(公告)号：US10458846B2

公开(公告)日：2019-10-29

申请号：US15748611

申请日：2015-08-31

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Francesco Aieta ,  Charles M. Santori ,  Anita Rogacs

IPC: G01J3/30 ,  G01N21/64 ,  G01N15/14 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G02B21/00 ,  G02B21/16 ,  G01N15/00 ,  G01N21/65 ,  G01N15/10

Abstract: In one implementation, a spectral microscope may comprise a substrate with a planar lens, the planar lens including a phase profile including an axial focus and an oblique focus, a light source to excite a signal of a particle among a plurality of particles, and a detector to receive light generated from the light source from the axial focus of the planar lens and a spectral color component of the excited signal of the particle from the oblique focus of the planar lens.

公开(公告)号：US10444155B2

公开(公告)日：2019-10-15

申请号：US16074630

申请日：2016-10-10

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor Shkolnikov ,  Steven J Simske ,  Michael A Delos-Reyes ,  Anita Rogacs

IPC: B82B1/00 ,  G01N21/65 ,  G01J3/44 ,  B82Y30/00 ,  G01N33/53

Abstract: An example device includes a substrate having a first surface, an electrowetting force generation layer above the first surface, and a nanostructure layer formed above the electrowetting force generation layer, the nanostructure layer having nano-fingers formed thereon. The electrowetting force generation layer is to generate an electrical field to selectively move at least one reactant on the nano-fingers of the nanostructure layer.

公开(公告)号：US10444153B2

公开(公告)日：2019-10-15

申请号：US15885035

申请日：2018-01-31

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Sang Kyu Kim

IPC: G01N21/65 ,  G01N21/66 ,  G01J3/44 ,  G01J3/10 ,  G01J3/42 ,  G01J3/02 ,  G01N21/359 ,  G01J3/12 ,  G01N21/47

Abstract: A spectrum measurement apparatus includes: a plurality of light sources configured to emit light having different wavelengths to an object; a light detector configured to receive light, which is reflected or scattered from or transmitted through the object, and to measure an intensity of the received light; and a processor configured to determine a strength of an electric signal to be applied to at least one of the plurality of light sources by using one of the plurality of light sources, and by applying the electric signal having the determined strength to the plurality of light sources to obtain a spectrum of the object.

公开(公告)号：US20190313036A1

公开(公告)日：2019-10-10

申请号：US16450374

申请日：2019-06-24

Applicant: Palo Alto Research Center Incorporated

Inventor： ALEX HEGYI ,  JOERG MARTINI

IPC: H04N5/33 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G02F1/13 ,  G01J3/00 ,  G01J3/453

Abstract: A method of calibrating a hyperspectral imaging device includes illuminating a hyperspectral imaging sensor with a light source having known spectral properties, sampling the light from the light source with the hyperspectral imaging sensor to obtain sampled spectral properties, and calibrating a performance characteristic of the hyperspectral imaging sensor based upon comparing the sampled spectral properties of the light source to the known spectral properties.

公开(公告)号：US20190310464A1

公开(公告)日：2019-10-10

申请号：US16348362

申请日：2017-11-09

Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

Inventor： Joachim Janes ,  Thorsten Giese

IPC: G02B26/10 ,  G02B26/08 ,  G01J3/02 ,  G01J3/42 ,  G01N21/64 ,  G01J3/44

Abstract: The invention relates to an image generation device comprising a laser light source (1); a mirror assembly having two parabolic mirrors (3, 6) via which a scanning light beam (1a, 5) generated by the laser light source is directed onto a sample surface (9); a deflection device (2), in particular a micromirror scanner, which is controllable such that the scanning light beam (1a, 5) scans points of the sample surface in a targeted manner; and a detector (10) which detects radiation emanating from a scanned point of the sample surface. The spatial resolution of the image generation device is substantially defined by the narrowest possible focusing of the laser beam, and the accuracy of the adjustable deflection angle is defined by the micromirror scanner.

公开(公告)号：US20190310199A1

公开(公告)日：2019-10-10

申请号：US16448670

申请日：2019-06-21

Applicant: Verily Life Sciences LLC

Inventor： Charles Santori ,  Supriyo Sinha ,  Cheng-Hsun Wu ,  James Higbie ,  Seung Ah Lee

IPC: G01N21/64 ,  G01J3/18 ,  A61B5/00 ,  G01J3/32 ,  G01J3/10 ,  G01J3/28 ,  G02B21/16 ,  G02B21/00 ,  G01J3/44 ,  G01J3/02 ,  G01J3/433

Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths and a diffractive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.

公开(公告)号：US10436716B2

公开(公告)日：2019-10-08

申请号：US14495295

申请日：2014-09-24

Applicant: Smiths Detection, Inc.

Inventor： Vincent Yuan-Hsiang Lee

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/02

Abstract: A substance analysis system and method are provided, the system disposable a variable stand-off distance from a substance in situ, including an emitter disposed to emit radiation onto the substance in situ, and a detector disposed the variable stand-off distance from the substance in situ, the detector comprising a receiver defining a substantially collimated collection path over the variable stand-off distance.

公开(公告)号：US20190277827A1

公开(公告)日：2019-09-12

申请号：US16421831

申请日：2019-05-24

Applicant: University of Vienna

Inventor： Alipasha Vaziri ,  Robert Prevedel

IPC: G01N33/483 ,  G01J3/44 ,  G01N21/63 ,  G01N21/64 ,  G02B21/16 ,  G02B21/02

Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.

公开(公告)号：US20190257760A1

公开(公告)日：2019-08-22

申请号：US16280651

申请日：2019-02-20

Applicant: OndaVia, Inc.

Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Samuel Kleinman

IPC: G01N21/65 ,  G01N33/18 ,  G01N21/47 ,  G01J3/18 ,  G01N27/447 ,  G01J3/44 ,  G01N30/60 ,  B01L3/00

Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

公开(公告)号：US10386283B2

公开(公告)日：2019-08-20

申请号：US15660409

申请日：2017-07-26

Applicant: Michael Trainer

Inventor： Michael Trainer

IPC: G01N21/53 ,  G01N15/02 ,  G01N15/14 ,  G01J3/44 ,  G01J3/453 ,  G02B6/32 ,  G01N15/04 ,  G01N21/47 ,  G01J3/02 ,  G01N15/00

Abstract: An instrument for measuring characteristics of particles. A particle sample is introduced into a sample cell. The sample particles are subjected to gravitational or centrifugal forces wherein particle motion is dependent upon particle characteristics. The particles are illuminated by an illumination device to produce light scattered by the particles. The light is detected by at least one detector. Characteristics of the particles are determined from the detector signals.