公开(公告)号：US20080316466A1

公开(公告)日：2008-12-25

申请号：US11765231

申请日：2007-06-19

Applicant: Richard J. Higgins ,  Betty Lise Anderson

Inventor： Richard J. Higgins ,  Betty Lise Anderson

IPC: G01N33/48 ,  G01J3/00 ,  G01J3/44

CPC classification number: A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/44 ,  G01N21/65

Abstract: Innovative techniques that result in a better signal-to-noise ratio for spectrographic analysis of substances in a target than conventional techniques. In these techniques, light illuminates a target with at least some of the light penetrating the target. At least a portion of the light that penetrates the target is collected from a region on the target's surface that is not directly illuminated. Preferably, at least a majority of the collected light is light that penetrates the target. Also preferably, the light that illuminates the target is in a pattern that partially but not completely surrounds the region from which the portion of the light that penetrates the target is collected. A spectrum of at least a portion of the collected light is analyzed.

Abstract translation: 创新技术可以使传统技术中目标物质的光谱分析具有更好的信噪比。 在这些技术中，光照射具有穿透靶的至少一些光的目标。 从目标表面上不直接照射的区域收集至少一部分穿透靶子的光线。 优选地，所收集的光的至少大部分是穿透靶的光。 还优选地，照射目标物的光是部分地但不完全地包围从其收集穿透靶的光的部分的区域的图案。 分析收集的光的至少一部分的光谱。

公开(公告)号：US07466407B2

公开(公告)日：2008-12-16

申请号：US11413877

申请日：2006-04-27

Applicant: Sean M. Spillane ,  Raymond G. Beausoleil ,  Zhiyong Li ,  Duncan Stewart

Inventor： Sean M. Spillane ,  Raymond G. Beausoleil ,  Zhiyong Li ,  Duncan Stewart

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman-enhancing structures include a photonic crystal having a resonant cavity and at least one waveguide coupled to the resonant cavity. A nanostructure comprising a Raman-enhancing material is disposed proximate the resonant cavity of the photonic crystal. Raman-enhancing structures include a microdisk resonator, at least one waveguide coupled to the microdisk resonator, and a nanostructure comprising a Raman-enhancing material disposed proximate the microdisk resonator. Methods for performing Raman spectroscopy include generating radiation, guiding the radiation through a waveguide to a resonant cavity in a photonic crystal or a microdisk resonator, resonating the radiation in the resonant cavity or microdisk resonator, providing an analyte proximate the resonant cavity or microdisk resonator, subjecting the analyte to the resonating radiation, and detecting Raman scattered radiation.

Abstract translation: 拉曼增强结构包括具有谐振腔和耦合到谐振腔的至少一个波导的光子晶体。 包含拉曼增强材料的纳米结构设置在光子晶体的谐振腔附近。 拉曼增强结构包括微盘谐振器，耦合到微盘谐振器的至少一个波导和包括靠近微盘谐振器设置的拉曼增强材料的纳米结构。 用于执行拉曼光谱的方法包括产生辐射，将辐射通过波导引导到光子晶体或微盘谐振器中的谐振腔，谐振谐振腔或微盘谐振器中的辐射，提供靠近谐振腔或微盘谐振器的分析物， 对分析物进行共振辐射，并检测拉曼散射辐射。

公开(公告)号：US07466406B2

公开(公告)日：2008-12-16

申请号：US11372583

申请日：2006-03-10

Applicant: Chad A. Mirkin ,  Lidong Qin ,  Can Xue ,  Sungho Park ,  Ling Huang

Inventor： Chad A. Mirkin ,  Lidong Qin ,  Can Xue ,  Sungho Park ,  Ling Huang

IPC: G01J3/44

CPC classification number: G01J3/44 ,  B82Y15/00 ,  G01N21/658 ,  Y10S977/762

Abstract: The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL).

Abstract translation: 本发明涉及使用具有纳米盘阵列的纳米线检测分析物的方法。 特别地，本发明公开了通过表面增强拉曼散射（SERS）检测分析物并使用在线光刻（OWL）制备的纳米线的方法。

公开(公告)号：US07463345B2

公开(公告)日：2008-12-09

申请号：US11647195

申请日：2006-12-29

Applicant: Jeffrey K. Cohen ,  John Maier ,  Robert Schweitzer

Inventor： Jeffrey K. Cohen ,  John Maier ,  Robert Schweitzer

IPC: G01J3/26

CPC classification number: G01N21/65 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/12 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

Abstract: A system and method of correlating Raman measurements with digital images of a treated sample to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. Information about the field of view is stored. The sample is removed from the field of view and treated. The treated sample is repositioned in the field of view using the stored information. A digital image of the treated sample is obtained and the spectroscopic data set is linked with the digital image. A database is provided having a plurality of spectroscopic data sets. Each data set is linked to a corresponding digital image, and associated with the known sample. Each corresponding digital image is associated with the known treated samples. The database is searched to identify and match a data set of a known sample and the sample.

Abstract translation: 将拉曼测量与经处理样品的数字图像相关联以将样品的疾病状态分类的系统和方法。 对于位于分光装置的视野中的样品获得光谱数据集。 存储有关视野的信息。 将样品从视野中移除并进行处理。 使用存储的信息，在视野中重新定位被处理的样品。 获得经处理样品的数字图像，并将光谱数据集与数字图像相连。 提供具有多个光谱数据集的数据库。 每个数据集都链接到相应的数字图像，并与已知样本相关联。 每个相应的数字图像与已知的处理样品相关联。 搜索数据库以识别和匹配已知样本和样本的数据集。

公开(公告)号：US20080278719A1

公开(公告)日：2008-11-13

申请号：US11747477

申请日：2007-05-11

Applicant: Ronald C. Fairchild

Inventor： Ronald C. Fairchild

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2021/651

Abstract: A material which is generally transparent in the visible region of the spectrum but reflective at laser wavelengths reduces undesirable, substrate-induced Raman and fluorescence scattering. A substrate provides a surface for supporting the sample, with the material being disposed between the surface of the substrate and the sample. The material is substantially transparent in the visible region of the spectrum but reflective at the laser wavelength, thereby minimizing unwanted Raman or fluorescence scattering that would be produced by the substrate if the material were not present. The substrate will typically be a glass microscope slide or multi-cell well plate. The optical filter material is preferably a multilayer dielectric filter acting as a “hot mirror” that reflects near-infrared energy. An advantage of visible transmission is that it allows back illumination from behind/underneath the slide or well plate, thereby being visible to a microscope's eyepiece or video camera. Methods and article are also disclosed.

Abstract translation: 通常在光谱可见区域是透明的但在激光波长下反射的材料减少了不期望的衬底诱导的拉曼和荧光散射。 衬底提供用于支撑样品的表面，其中材料设置在衬底的表面和样品之间。 该材料在光谱的可见光区域基本上是透明的，但是在激光波长处是反射性的，从而如果该材料不存在，则最小化由衬底产生的不需要的拉曼或荧光散射。 基底通常是玻璃显微镜载玻片或多细胞孔板。 滤光器材料优选是用作反射近红外能量的“热镜”的多层介质滤光器。 可见透射的一个优点是它可以从后面/下面的滑板或孔板进行背光照射，从而对于显微镜的目镜或摄像机是可见的。 还披露了方法和文章。

公开(公告)号：US07436501B2

公开(公告)日：2008-10-14

申请号：US11363082

申请日：2006-02-28

Applicant: Takeshi Hashimoto ,  Shinichi Hayashi ,  Junichi Kitagawa

Inventor： Takeshi Hashimoto ,  Shinichi Hayashi ,  Junichi Kitagawa

IPC: G01N21/64 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/653 ,  G01N2021/656

Abstract: In one or more embodiments, a microscope has a first pulsed laser and a second pulsed laser arranged to irradiate a specimen. Coherent Raman scattering light emanated from the irradiated specimen is extracted, along with multiphoton excitation fluorescence and a second harmonic wave. One or more detectors detect the extracted coherent Raman scattering light, the extracted fluorescence, and the second harmonic wave. A single specimen can simultaneously be observed with respect to either parallel or selective observations of the two-photon excitation fluorescence, the second harmonic wave, and the coherent Raman scattered light.

Abstract translation: 在一个或多个实施例中，显微镜具有第一脉冲激光器和布置成照射样本的第二脉冲激光器。 从被照射的样本中发出的相干拉曼散射光与多光子激发荧光和二次谐波一起被提取。 一个或多个检测器检测提取的相干拉曼散射光，提取的荧光和二次谐波。 相对于双光子激发荧光，二次谐波和相干拉曼散射光的平行或选择性观察，可以同时观察到单个样本。

公开(公告)号：US20080231859A1

公开(公告)日：2008-09-25

申请号：US12050218

申请日：2008-03-18

Applicant: Masaya Ogino

Inventor： Masaya Ogino

IPC: G01J3/45

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  H01L27/146

Abstract: A photodetection device, a photodetection method, an image sensor and an image pickup method can increase the number of pixels, while suppressing degradation of the S/N ratio. The photodetection device includes a spectroscopic element formed by means of an optical microresonator having a plurality of resonant wavelength bands differentiated by positions as a function of a geometric structure and a plurality of photoelectric conversion elements arranged at different positions to detect light of the plurality of resonant wavelength bands.

Abstract translation: 光检测装置，光检测方法，图像传感器和图像拾取方法可以增加像素的数量，同时抑制S / N比的降低。 光检测装置包括通过光学微谐振器形成的分光元件，该分光元件具有由作为几何结构的函数的位置而区分的多个谐振波长带，以及布置在不同位置处的多个光电转换元件，以检测多个谐振的光 波段。

公开(公告)号：US07426025B2

公开(公告)日：2008-09-16

申请号：US11233686

申请日：2005-09-23

Applicant: Shih-Yuan Wang

Inventor： Shih-Yuan Wang

IPC: G01J3/44

CPC classification number: G01J3/44 ,  B82Y15/00 ,  G01N21/658 ,  Y10S977/951

Abstract: Nanostructures configured to enhance the intensity of Raman scattered radiation scattered by an analyte include a substantially planar substrate, a plurality of nanoparticles disposed on a surface of the substrate, and a Raman-enhancing material disposed on at least a portion of at least one nanoparticle. Each nanoparticle is configured to emit lased radiation upon stimulation of the nanoparticle and may comprise a nanowire laser. Raman spectroscopy systems include a radiation source, a radiation detector configured to detect Raman scattered radiation scattered by an analyte, a nanostructure including at least one nanoparticle configured to emit lased radiation upon stimulation, and means for stimulating the nanoparticle. Methods for performing Raman spectroscopy include providing a nanostructure including at least one nanoparticle configured to emit lased radiation upon stimulation of the nanoparticle, providing an analyte proximate to the nanoparticle, stimulating the nanoparticle, and detecting Raman scattered radiation.

Abstract translation: 被配置为增强由分析物散射的拉曼散射辐射的强度的纳米结构体包括基本平坦的基底，设置在基底的表面上的多个纳米颗粒以及设置在至少一个纳米颗粒的至少一部分上的拉曼增强材料。 每个纳米颗粒被配置为在刺激纳米颗粒时发射带激光的辐射，并且可以包括纳米线激光器。 拉曼光谱系统包括辐射源，被配置为检测被分析物散射的拉曼散射辐射的辐射检测器，包括至少一个纳米颗粒的纳米结构，所述纳米结构被配置为在刺激时发射带激光的辐射，以及用于刺激纳米颗粒的装置。 用于进行拉曼光谱的方法包括提供包括至少一种纳米颗粒的纳米结构，所述纳米结构被配置为在刺激纳米颗粒时发射激光辐射，提供靠近纳米颗粒的分析物，刺激纳米颗粒，以及检测拉曼散射辐射。

公开(公告)号：US07420672B2

公开(公告)日：2008-09-02

申请号：US11820706

申请日：2007-06-20

Applicant: Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

Inventor： Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J2003/1213 ,  G01N2021/656

Abstract: Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.

Abstract translation: 本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。 第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

公开(公告)号：US20080204715A1

公开(公告)日：2008-08-28

申请号：US11916997

申请日：2006-06-13

Applicant: Andreas Klehr ,  Bernd Sumpf ,  Martin Maiwald ,  Heinar Schmidt

Inventor： Andreas Klehr ,  Bernd Sumpf ,  Martin Maiwald ,  Heinar Schmidt

IPC: G01N21/00 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/4424 ,  G01N2021/656

Abstract: The invention relates to a method and a device for producing and detecting a Raman spectrum. The problem addressed by the present invention is that of devising a method and a device for producing and detecting a Raman spectrum of a medium under investigation, whereby the Raman spectrum of a medium that is under investigation can be examined with a high degree of sensitivity while requiring relatively little equipment. The method is characterized by the coupling of excitation radiation into a medium (8) under investigation and the coupling of the electromagnetic radiation scattered by the medium (8) under investigation into a spectral optic system (10), a laser diode (1) for generating excitation radiation with at least two different wavelengths (λ1, λ2) being controlled with at least two different excitation conditions and at least one Raman spectrum (16, 17) being detected in each case from the scattered radiation at the different excitation wavelengths (λ1, λ2), and the Raman spectrum (20) of the medium (8) under investigation being determined from the at least two detected Raman spectra (16, 17), the two different excitation conditions for the laser diode (1) being adjusted by means of the electric current supplied to the laser diode (1).

Abstract translation: 本发明涉及一种用于产生和检测拉曼光谱的方法和装置。 本发明提出的问题在于，设计用于制造和检测正在研究的介质的拉曼光谱的方法和装置，由此可以高灵敏度地检查正在研究的介质的拉曼光谱，同时 需要相对较少的设备。 该方法的特征在于将激发辐射耦合到正在研究的介质（8）中，并将被研究的介质（8）散射的电磁辐射耦合到光谱系统（10）中，激光二极管（1）用于 用至少两个不同的激发条件和至少一个拉曼光谱（16,17）来控制具有至少两个不同波长（λ1，λ2 2）的激发辐射， 在不同的激发波长（λ1，λ2 2）处的散射辐射以及介质（8）的拉曼光谱（20）在每种情况下被检测到 通过至少两个检测的拉曼光谱（16,17）确定调查，通过提供给激光二极管（1）的电流来调节激光二极管（1）的两个不同激发条件。