公开(公告)号：US20090206240A1

公开(公告)日：2009-08-20

申请号：US12369371

申请日：2009-02-11

Applicant: Takashi MUROOKA ,  Hideyasu Ishibashi ,  Ichiro Amimori

Inventor： Takashi MUROOKA ,  Hideyasu Ishibashi ,  Ichiro Amimori

IPC: G01J1/04 ,  G02B5/30

CPC classification number: G02B27/288 ,  G01J3/28

Abstract: Provided is an optical device, comprising a plurality of polarizers that are arranged along a propagation direction of incident light; a first phase element that is disposed between the plurality of polarizers and that has a phase lag axis forming a prescribed angle relative to transmission axes of the polarizers arranged along the propagation direction; and a second phase element that is disposed between the first phase element and one of the polarizers arranged along the propagation direction, and that provides the incident light with a prescribed phase difference. An angle of the phase lag axis of the second phase element is adjusted such that the optical device transmits light in a prescribed wavelength region in the incident light.

Abstract translation: 提供了一种光学装置，包括沿着入射光的传播方向布置的多个偏振器; 第一相位元件，其设置在所述多个偏振器之间并且具有相对于沿着所述传播方向布置的偏振器的透射轴形成规定角度的相位滞后轴; 以及第二相位元件，其设置在沿着传播方向布置的第一相位元件和偏振器中的一个之间，并且提供具有规定相位差的入射光。 调整第二相位元件的相位延迟轴的角度，使得光学装置在入射光中透射规定波长区域中的光。

公开(公告)号：US07557924B2

公开(公告)日：2009-07-07

申请号：US11504120

申请日：2006-08-15

Applicant: Jon K. Nisper ,  Michael J. Mater

Inventor： Jon K. Nisper ,  Michael J. Mater

IPC: G01J3/51

CPC classification number: G01J3/28 ,  G01J3/0275 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/50 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01J2003/1282 ,  G01J2003/2866 ,  G01J2003/467

Abstract: An optical system comprising an optical instrument and a processing unit. The optical instrument may comprise an illumination source and a sensor. The processing unit may comprise a data storage having stored thereon a characterization of the illumination source and a characterization of the sensor. The processing unit may also comprise a computer configured to calculate a system response of the illumination source and the receiving element considering the characterization of the illumination source and the characterization of the receiving element.

Abstract translation: 一种光学系统，包括光学仪器和处理单元。 光学仪器可以包括照明源和传感器。 处理单元可以包括其上存储有照明源的表征和传感器的表征的数据存储器。 处理单元还可以包括计算机，其被配置为考虑照明源的特征和接收元件的表征来计算照明源和接收元件的系统响应。

公开(公告)号：US20090141266A1

公开(公告)日：2009-06-04

申请号：US11998213

申请日：2007-11-29

Applicant: Christopher Lin ,  Deepak Devicharan

Inventor： Christopher Lin ,  Deepak Devicharan

IPC: G01N21/00

CPC classification number: G01J3/26 ,  G01J3/28 ,  G01J2003/2866 ,  G01M11/00 ,  G02F2203/055

Abstract: The specification describes an optical wavelength monitor/analyzer that uses a cost effective wavelength reference source. The wavelength reference source is a nominally fixed wavelength laser with inherent tunability over a very limited wavelength range, i.e. a few nanometers. Tuning is effected by changing the temperature of the laser. The limited range is useful for making multiple wavelength measurements in the context of analyzing wavelength drift in tunable optical filters.

Abstract translation: 该规范描述了使用成本有效的波长参考源的光学波长监视器/分析仪。 波长参考源是名义上固定的波长激光器，其在非常有限的波长范围内具有固有的可调谐性，即几纳米。 通过改变激光的温度来实现调谐。 有限的范围对于在可调谐光学滤波器中分析波长漂移的上下文中进行多个波长测量是有用的。

公开(公告)号：US20090138205A1

公开(公告)日：2009-05-28

申请号：US12266060

申请日：2008-11-06

Applicant: Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

Inventor： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

IPC: G06F19/00 ,  G06F15/00

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

Abstract: An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

Abstract translation: 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

公开(公告)号：US20090114804A1

公开(公告)日：2009-05-07

申请号：US12349001

申请日：2009-01-06

Applicant: Dmitry M. Sagatelyan

Inventor： Dmitry M. Sagatelyan

IPC: G12B13/00

CPC classification number: G01J1/08 ,  G01J1/4228 ,  G01J3/28 ,  G01J3/2803 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  H04N5/35536 ,  H04N5/357 ,  H04N5/361 ,  H04N17/002

Abstract: A method and system for characterizing and quantifying various error and calibration components of signals associated with photo-detectors. By varying the detector operational parameters such as input light intensity and integration times, measured signals can be analyzed to separate out and quantify various components of the measured signals. The various components thus determined may be categorized according to their dependencies on the operational parameters. Such component characterization allows better understanding of the detector system and ways in which such system can be improved so as to yield an improved measurement result for which the detector is being utilized.

Abstract translation: 用于表征和量化与光电检测器相关联的信号的各种误差和校准分量的方法和系统。 通过改变检测器的操作参数，例如输入光强度和积分时间，可以分析测量信号以分离和量化测量信号的各种分量。 这样确定的各种组件可以根据其对操作参数的依赖性进行分类。 这种组件表征允许更好地理解检测器系统以及可以改进这种系统的方式，以便产生检测器被利用的改进的测量结果。

公开(公告)号：US20090101843A1

公开(公告)日：2009-04-23

申请号：US11541935

申请日：2006-10-02

Applicant: Philip D. Henshaw ,  Pierre C. Trepagnier

Inventor： Philip D. Henshaw ,  Pierre C. Trepagnier

IPC: H05B33/00 ,  G01J3/00

CPC classification number: G01J3/28 ,  G01J3/44 ,  G01N21/6408 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2201/129

Abstract: The present invention generally provides systems and methods for detection of agents of interest in a bulk quantity of matter, which also contains clutter and other constituents that typically interfere with the detection of one or more agents of interest. A detection system of the invention generally contains a collection subsystem for obtaining a bulk sample, an interrogation subsystem for generating one or more analytical signals representative of the composition of the bulk sample, and an analytical subsystem according to the teachings of the invention that implements the methods and algorithms of the invention for analyzing the sample analytical signals to determine whether one or more agents of interest are present, e.g., at quantities above a certain threshold, in the bulk sample.

Abstract translation: 本发明通常提供用于检测大量物质中感兴趣的试剂的系统和方法，其还含有通常干扰一种或多种感兴趣的试剂的检测的杂波和其它成分。 本发明的检测系统通常包含用于获得批量样品的收集子系统，用于产生表示大体积样品的组成的一个或多个分析信号的询问子系统，以及根据本发明教导的分析子系统， 本发明的方法和算法用于分析样本分析信号，以确定在批量样本中是否存在一种或多种感兴趣的试剂，例如高于某一阈值的量。

公开(公告)号：US20090086205A1

公开(公告)日：2009-04-02

申请号：US12248272

申请日：2008-10-09

Applicant: Jacob Grun ,  Sergei Nikitin ,  Charles K. Manka

Inventor： Jacob Grun ,  Sergei Nikitin ,  Charles K. Manka

IPC: G01J3/30

CPC classification number: G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/1293

Abstract: A spectroscopic detector includes a tunable light source, such as a continuously tunable, optical parametric oscillator laser; means for measuring the emitted radiation at a plurality of emission wavelengths to obtain a plurality of spectral measurement data; and a processor for processing the spectral measurement data, where the processor includes a multispectral data processing algorithm or is configured for 1) combining the plurality of spectral measurement data into a composite spectrum, and 2) applying the algorithm to the composite spectrum. The spectra such as resonant and near-resonant Raman Spectra that are acquired are more complete and contain more information. A powerful multispectral analysis code such as IHPS, CHOMPS, or ENN analyzes the acquired data points, examining details of the spectra that could not be handled by traditional methods.

Abstract translation: 光谱检测器包括可调谐光源，例如连续可调的光学参量振荡器激光器; 用于测量多个发射波长处的发射辐射以获得多个光谱测量数据的装置; 以及用于处理所述光谱测量数据的处理器，其中所述处理器包括多光谱数据处理算法或者被配置为1）将所述多个光谱测量数据组合成复合光谱，以及2）将所述算法应用于所述复合光谱。 所获得的诸如共振和近共振拉曼光谱的光谱更完整并包含更多信息。 一个强大的多光谱分析代码，如IHPS，CHOMPS或ENN，分析所获得的数据点，检查传统方法无法处理的光谱细节。

公开(公告)号：US07511812B2

公开(公告)日：2009-03-31

申请号：US11570133

申请日：2005-06-13

Applicant: Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

Inventor： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC: G01J3/30

CPC classification number: G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

Abstract: A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.

Abstract translation: 确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。 在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。 由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

公开(公告)号：US20090079979A1

公开(公告)日：2009-03-26

申请号：US12212016

申请日：2008-09-17

Applicant: Hiroyuki Minato

Inventor： Hiroyuki Minato

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/027

Abstract: A spectrophotometer is provided capable of reducing the influence of the vibration as much as possible when a wavelength dispersion element is rotationally driven and capable of increasing the analysis accuracy. When a fluorescence signal is obtained from the fluorescence detector, the central control unit A/D converts the fluorescence signal at sampling intervals of T1 for vibration convergence determination, and provides the result data to the data processor (S1). At the timing of performing the vibration convergence determination (S2), the data processor performs a predetermined signal processing to the digital signals obtained (S3), and determines whether all the data that have been obtained within a given period of time from the latest data are equal to or smaller than a specified value (S4). If all the data are equal to or smaller than the specified value, it is determined that the diffraction grating's vibration is converged, and the vibration convergence determination operation is terminated. After that, the central control unit changes the A/D conversion sampling interval to the interval T2 for obtaining the analysis data, and performs a spectrofluorometric measurement.

Abstract translation: 提供一种分光光度计，其能够在波长分散元件旋转驱动时尽可能地减小振动的影响，并且能够提高分析精度。 当从荧光检测器获得荧光信号时，中央控制单元A / D以用于振动收敛确定的采样间隔T1转换荧光信号，并将结果数据提供给数据处理器（S1）。 在执行振动收敛判定（S2）的定时，数据处理器对获得的数字信号进行预定的信号处理（S3），并且确定在最近的数据中在给定时间段内获得的所有数据 等于或小于规定值（S4）。 如果所有数据均等于或小于指定值，则确定衍射光栅的振动被收敛，并且终止振动收敛确定操作。 之后，中央控制单元将A / D转换采样间隔改变为间隔T2以获得分析数据，并执行分光荧光测量。

公开(公告)号：US07509239B2

公开(公告)日：2009-03-24

申请号：US11716425

申请日：2007-03-09

Applicant: Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

Inventor： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

IPC: G03F1/26

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

Abstract: An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

Abstract translation: 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。