公开(公告)号：US07405822B2

公开(公告)日：2008-07-29

申请号：US11584020

申请日：2006-10-20

Applicant: Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

Abstract translation: 拉曼光谱系统包括分析物，被配置为发射具有波长的入射辐射的辐射源，以及检测器，其能够仅检测波长在可检测范围内的辐射，所述波长包括对应于由所述波长散射的超拉曼散射辐射的至少一个波长 分析物。 入射辐射的波长在可检测范围之外。 在特定系统中，在检测器的方向上散射的所有辐射波长都照射在检测器上。 拉曼光谱方法包括提供分析物并用具有波长的入射辐射照射分析物，提供检测器，该检测器仅能够检测不包括入射辐射波长的可检测范围内的辐射波长，并且检测散射的拉曼散射辐射 分析物。 可以在分析物和检测器之间提供不含辐射过滤器的连续路径。

公开(公告)号：US07400395B2

公开(公告)日：2008-07-15

申请号：US11264433

申请日：2005-10-31

Applicant: Selena Chan ,  Andrew A. Berlin ,  Sunghoon Kwon ,  Narayanan Sundararajan ,  Mineo Yamakawa

Inventor： Selena Chan ,  Andrew A. Berlin ,  Sunghoon Kwon ,  Narayanan Sundararajan ,  Mineo Yamakawa

IPC: G01J3/44

CPC classification number: C12Q1/6825 ,  B82Y15/00 ,  B82Y30/00 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/6439 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/632 ,  C12Q2563/155

Abstract: The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon by cathodic electromigration or any known technique. In certain alternatives, the metal coated porous silicon substrate comprises a plasma-oxidized, dip and decomposed porous silicon substrate. The metal-coated substrate provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain alternatives, metal nanoparticles may be added to the metal-coated substrate to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus. In some disclosed methods, Raman spectroscopy may be used to detect nucleotides, purines or pyrimidines at the single molecule level.

Abstract translation: 所公开的方法和装置涉及使用金属涂覆的纳米晶体多孔硅衬底的拉曼光谱。 多孔硅衬底可以通过在稀氢氟酸中的阳极蚀刻形成。 拉曼活性金属（例如金或银）的薄涂层可以通过阴极电迁移或任何已知技术涂覆在多孔硅上。 在某些替代方案中，金属涂覆的多孔硅衬底包括等离子体氧化的，浸渍和分解的多孔硅衬底。 金属涂层的基底为SERS，SERRS，超拉曼和/或CARS拉曼光谱提供了广泛的金属丰富的环境。 在某些替代方案中，可以将金属纳米颗粒加入到金属涂覆的基底中以进一步增强拉曼信号。 使用所公开的方法和装置，可以使用拉曼光谱来检测，鉴定和/或定量各种分析物。 在一些公开的方法中，可以使用拉曼光谱法在单一分子水平检测核苷酸，嘌呤或嘧啶。

公开(公告)号：US20080158568A1

公开(公告)日：2008-07-03

申请号：US12044020

申请日：2008-03-07

Applicant: Glenn Scott Claydon ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Renato Guida ,  David Cecil Hays ,  Dirk Lange ,  Boon Kwee Lee ,  Sandip Maity ,  Long Que ,  Anis Zribi

Inventor： Glenn Scott Claydon ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Renato Guida ,  David Cecil Hays ,  Dirk Lange ,  Boon Kwee Lee ,  Sandip Maity ,  Long Que ,  Anis Zribi

IPC: G01B9/02

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/26 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/0221

Abstract: An interferometer includes a resonant cavity having a movable mirror and at least one fiber optic component acting as a fixed mirror. A surface of the fiber optic component is coated with a reflective film. An actuator is coupled to the movable mirror, such that when a scattered optical beam is coupled to the cavity, interference occurs between the surface of the fiber optic component coated with reflective film and a surface of the movable mirror facing the surface of the fiber optic component coated with reflective film. The reflective film on the surface of the fiber optic component causes closely spaced spectral lines within the scattered optical beam to be suitably resolved.

Abstract translation: 干涉仪包括具有可移动反射镜的谐振腔和用作固定镜的至少一个光纤部件。 光纤部件的表面涂覆有反射膜。 致动器耦合到可移动反射镜，使得当散射的光束耦合到空腔时，在涂覆有反射膜的光纤部件的表面与可移动镜的面向光纤表面的表面之间发生干涉 涂有反射膜的部件。 光纤组件表面上的反射膜导致散射光束内的紧密间隔的光谱线被适当地分辨。

公开(公告)号：US07385691B2

公开(公告)日：2008-06-10

申请号：US11044676

申请日：2005-01-27

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44 ,  H01L31/02325 ,  H01L31/105

Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在基板上或者离开基板。 分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

公开(公告)号：US07385681B2

公开(公告)日：2008-06-10

申请号：US10548194

申请日：2004-03-05

Applicant: Hideki Ninomiya ,  Koji Ichikawa ,  Ken Kawahara ,  Hirofumi Miki ,  Tasuku Moriya

Inventor： Hideki Ninomiya ,  Koji Ichikawa ,  Ken Kawahara ,  Hirofumi Miki ,  Tasuku Moriya

IPC: G01C3/08

CPC classification number: G01N21/65 ,  F23N5/24 ,  G01J3/36 ,  G01J3/44 ,  G01J5/0018 ,  G01J5/602 ,  G01J2005/0077 ,  G01M3/38 ,  G01N21/33

Abstract: A gas leakage monitoring method and system capable of ensuring safety of a gas utilization facility by visualizing invisible-to-naked-eye leakage gas and/or flame of leakage gas into the form of an image. The gas leakage monitoring method comprises the steps of collecting a detected light of a particular wavelength, which is caused by leakage gas and/or a flame of the leakage gas, in a space to be monitored, converting the detected light into an electronic image, amplifying and then converting the electronic image into an optical image again, and imaging the spatial intensity distribution of the particular wavelength light. The gas leakage monitoring system comprises first means for collecting a detected light of a particular wavelength, which is caused by leakage gas and/or a flame of the leakage gas, in a space to be monitored, second means for converting the detected light into an electronic image, and amplifying and then converting the electronic image into an optical image again, and third means for imaging the spatial intensity distribution of the particular wavelength light.

Abstract translation: 一种气体泄漏监测方法和系统，其能够通过将不可见的裸眼泄漏气体和/或泄漏气体的火焰视觉为图像的形式来确保气体利用设施的安全性。 气体泄漏监测方法包括以下步骤：在要监视的空间中收集由泄漏气体和/或泄漏气体的火焰引起的特定波长的检测光，将检测到的光转换成电子图像， 放大然后再次将电子图像转换成光学图像，并且对特定波长的光的空间强度分布进行成像。 气体泄漏监测系统包括用于在要监视的空间中收集由泄漏气体和/或泄漏气体的火焰引起的特定波长的检测光的第一装置，用于将检测到的光转换为 电子图像，然后放大然后再次将电子图像转换成光学图像;以及第三装置，用于对特定波长的光的空间强度分布进行成像。

公开(公告)号：US07384792B1

公开(公告)日：2008-06-10

申请号：US10852787

申请日：2004-05-24

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: G01N21/03 ,  G01N33/558 ,  B32B3/02 ,  B32B7/12 ,  H01J9/04

CPC classification number: G01N21/658 ,  G01J3/44 ,  Y10T428/218 ,  Y10T428/28

Abstract: A method to fabricate an optical scattering probe and the method includes the steps of a) depositing an conductive layer on a substrate followed by depositing a noble metal layer on top of the conductive layer and then an aluminum layer on top the noble metal layer; b) anodizing the aluminum layer to form a porous aluminum oxide layer having a plurality of pores; and c) etching the plurality of pores through the aluminum oxide layer and the noble metal layer for forming a nano-hole array. In a preferred embodiment, the step of etching the plurality of pores through the aluminum oxide layer and the noble metal layer further comprising a step of widening the pores followed by removing the aluminum oxide layer for forming a plurality of noble metal column on top of the conductive layer.

Abstract translation: 一种制造光散射探针的方法，包括以下步骤：a）在衬底上沉积导电层，然后在导电层的顶部沉积贵金属层，然后在贵金属层顶上沉积铝层; b）阳极氧化铝层以形成具有多个孔的多孔氧化铝层; 以及c）通过氧化铝层和用于形成纳米孔阵列的贵金属层蚀刻多个孔。 在优选实施例中，通过氧化铝层和贵金属层蚀刻多个孔的步骤还包括扩大孔的步骤，随后除去用于形成多个贵金属柱的氧化铝层 导电层。

公开(公告)号：US20080094624A1

公开(公告)日：2008-04-24

申请号：US11686820

申请日：2007-03-15

Applicant: KEVIN HARSH ,  BRIAN SCHAIBLE ,  WENGE ZHANG ,  WILLIAM GARRETT ,  CHRISTOPHER P. MATTISON

Inventor： KEVIN HARSH ,  BRIAN SCHAIBLE ,  WENGE ZHANG ,  WILLIAM GARRETT ,  CHRISTOPHER P. MATTISON

IPC: G01J3/443

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/443 ,  G01N21/274 ,  G01N21/6428

Abstract: An improved optical sensor and methods for measuring the presence of various materials or constituents in a fluid sample uses one or more reactive materials in a fluid environment. The reactive materials have optical properties that change in the presence of one or more target materials that may be present in the environment. One or more optical emitters generate light that is directed to the reactive material(s), and one or more optical detectors receive light from the reactive material(s), and the presence or absence of the target material is determined based on the light received at the optical detector(s). The reactive material(s), emitter(s), and detector(s) are selected based on the desired target material to be sensed.

Abstract translation: 用于测量流体样品中各种材料或组分的存在的改进的光学传感器和方法使用流体环境中的一种或多种反应性材料。 反应性材料具有在可能存在于环境中的一种或多种目标材料存在下变化的光学性质。 一个或多个光学发射器产生被引导到反应性材料的光，并且一个或多个光学检测器接收来自反应性材料的光，并且基于所接收的光来确定目标材料的存在或不存在 在光学检测器处。 反应性材料，发射器和检测器基于要感测的期望目标材料来选择。

公开(公告)号：US07362430B2

公开(公告)日：2008-04-22

申请号：US10519529

申请日：2003-06-26

Applicant: Quy Dao Nguyen ,  Edouard Da Silva

Inventor： Quy Dao Nguyen ,  Edouard Da Silva

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/04 ,  G01J3/02 ,  G01J3/021 ,  G01J3/44

Abstract: The invention concerns a Raman spectrometry apparatus containing a source of excitation (14), optical means (16) of excitation directing a beam of excitation (15) derived from that source on the sample (17), means (18) for collecting the energy diffused by the sample (17) containing an inlet diffusion slot (19), a spectral dispersion system (20), means for selecting the Raman energy (23), a detector (22), optical detection means (21) directing the Raman energy thus collected and selected to the detector (22). According to the invention, the optical means (16) of excitation cause the beam of excitation (15) to be dispersed by the dispersion system (20), said optical means (16) of excitation containing an inlet slot (24) and an outlet slot of excitation constituted by the inlet diffusion slot (19) and selecting the wavelength of excitation.

Abstract translation: 本发明涉及一种包含激发源（14）的拉曼光谱测量装置，用于引导源自该源的样品（17）的激发光束（15）的激发光学装置（16），用于收集能量的装置（18） 由包含入口扩散槽（19）的样品（17）扩散，光谱色散系统（20），用于选择拉曼能量的装置（23），检测器（22），引导拉曼能量的光学检测装置（21） 从而被收集并选择到检测器（22）。 根据本发明，激发光学装置（16）使得激发光束（15）被分散系统（20）分散，所述激光的光学装置（16）包含入口狭槽（24）和出口 由入口扩散槽（19）构成并选择激发波长的激励槽。

公开(公告)号：US20080062417A1

公开(公告)日：2008-03-13

申请号：US11852825

申请日：2007-09-10

Applicant: James W. Stave ,  Matthew H. Knight

Inventor： James W. Stave ,  Matthew H. Knight

IPC: G01J3/44

CPC classification number: G01N21/65 ,  C02F1/008 ,  C02F1/5209 ,  G01J3/44 ,  G01N21/658 ,  G01N33/1826 ,  G01N2021/653

Abstract: Compositions and methods utilizing Raman Spectroscopy to detect and determine, directly or indirectly, the concentration of water treatment polymers in water or methods for measuring or quantifying the amount of water treatment polymer in a sample, such as an industrial, commercial, or municipal water sample, are provided. The compositions contain water treatment polymers that have been modified to include one or more Raman-active functional groups. The methods utilize Raman spectroscopy to detect the presence or amount of water treatment polymer either directly or indirectly. The method provides the ability to detect or measure the amount of active water treatment polymer remaining in the sample.

Abstract translation: 使用拉曼光谱法的组合物和方法直接或间接地检测和测定水中水处理聚合物的浓度或测量或定量样品中的水处理聚合物的量的方法，例如工业，商业或城市水样品 ，提供。 该组合物含有经过改性以包括一个或多个拉曼活性官能团的水处理聚合物。 该方法利用拉曼光谱法直接或间接地检测水处理聚合物的存在或量。 该方法提供检测或测量残留在样品中的活性水处理聚合物的量的能力。

公开(公告)号：US20080059135A1

公开(公告)日：2008-03-06

申请号：US11781602

申请日：2007-07-23

Applicant: Sangeeta Murugkar ,  Hanan Anis ,  Xiaoliang Xie ,  Conor Evans

Inventor： Sangeeta Murugkar ,  Hanan Anis ,  Xiaoliang Xie ,  Conor Evans

IPC: G06G7/48

CPC classification number: G01J3/44 ,  G01J3/4338 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/653

Abstract: The invention provides a system and method for automatic real-time monitoring for the presence of a pathogen in water using coherent anti-stokes Raman scattering (CARS) microscopy. Water sample trapped in a trapping medium is provided to a CARS imager. CARS images are provided to a processor for automatic analyzing for the presence of image artifacts having pre-determined features characteristic to the pathogen. If a match is found, a CARS spectrum is taken and compared to a stored library of reference pathogen-specific spectra for pathogen identification. The system enables automatic pathogen detection in flowing water in real time.

Abstract translation: 本发明提供一种用于使用相干抗斯托克斯拉曼散射（CARS）显微镜自动实时监测水中病原体存在的系统和方法。 捕获介质中的水样被提供给CARS成像仪。 将CARS图像提供给处理器，用于自动分析具有对病原体特征的预定特征的图像伪影的存在。 如果发现匹配，则采集CARS光谱，并将其与用于病原体鉴定的参考病原体特异性光谱的存储库进行比较。 该系统实时实现流水中的自动病原体检测。