公开(公告)号：US20240359313A1

公开(公告)日：2024-10-31

申请号：US18646639

申请日：2024-04-25

Applicant: University of Utah Research Foundation

Inventor： Sergei V. SARKISIAN ,  Tommaso LENZI ,  Lukas R. GABERT ,  Brendon M. ORTOLANO

IPC: B25J9/00

CPC classification number: B25J9/0006 ,  A61H1/0266 ,  A61H3/00

Abstract: Disclosed is a lightweight powered ankle exoskeleton with integrated series-elastic actuation capable of providing high torque and power densities while maintaining a compact and lightweight profile. The exoskeleton includes: a frame configured to be worn adjacent a lower leg of a user; a power transmission assembly integrated with the frame and configured to deliver torque to a crank member to rotate the crank member about an ankle joint; and a foot/shoe interface coupled to the crank member and configured to interface with a foot or shoe of the user and to transmit torque generated at the ankle joint to the foot or shoe of the user.

公开(公告)号：US12098454B2

公开(公告)日：2024-09-24

申请号：US18184373

申请日：2023-03-15

Applicant: University of Utah Research Foundation

Inventor： James D. Paramore ,  Brady G. Butler ,  Matthew K. Dunstan ,  Jonathan P. Ligda ,  Zhigang Z. Fang

IPC: C22C14/00 ,  C22F1/02 ,  C22F1/18

CPC classification number: C22F1/183 ,  C22F1/02

Abstract: A method of refining a microstructure of a titanium material can include providing a solid titanium material at a temperature below about 400° C. The titanium material can be heated under a hydrogen-containing atmosphere to a hydrogen charging temperature that is above a β transus temperature of the titanium material and below a melting temperature of the titanium material, and held at this temperature for a time sufficient to convert the titanium material to a substantially homogeneous β phase. The titanium material can be cooled under the hydrogen-containing atmosphere to a phase transformation temperature below the β transus temperature and above about 400° C., and held for a time to produce a phase regions. The titanium material can also be held under a substantially hydrogen-free atmosphere or vacuum at a dehydrogenation temperature below the β transus temperature and above the δ phase decomposition temperature to remove hydrogen from the titanium material.

公开(公告)号：US20240285530A1

公开(公告)日：2024-08-29

申请号：US18112720

申请日：2023-02-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Nitish KHURANA ,  Hamidreza GHANDEHARI ,  Kevin WATT ,  Venkata YELLEPEDDI

IPC: A61K9/107 ,  A61K9/127 ,  A61K31/05

CPC classification number: A61K9/1075 ,  A61K9/1271 ,  A61K31/05 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: Described herein are methods for administering a hydrophobic pharmaceutical agent to subjects undergoing extracorporeal membrane oxygenation (ECMO) device therapy while diminishing adsorption of the hydrophobic pharmaceutical agent to the ECMO device. In one embodiment, the method comprises administering the hydrophobic pharmaceutical agent encapsulated in an amphipathic encapsulating agent. In one aspect, the hydrophobic pharmaceutical agent is propofol and the amphipathic encapsulating agent is polyethylene-polypropylene glycol (Poloxamer 407) or a PEGylated liposome. In another aspect, PEGylated propofol is synthesized and used to prevent adsorption to the ECMO device.

公开(公告)号：US20240255315A1

公开(公告)日：2024-08-01

申请号：US18159895

申请日：2023-01-26

Applicant: University of Utah Research Foundation

Inventor： Matthieu Couriol ,  Pierre-Emmanuel Gaillardon

IPC: G01D5/16

CPC classification number: G01D5/16

Abstract: A sensor interface for a resistive sensor has an analog front end comprising. The analog front end has an analog input/output (I/O) sensor port to be coupled to the resistive sensor. An integration stage is coupled to the analog I/O sensor port to oscillate at an oscillation frequency proportional to a sensor resistance of the resistive sensor. The integration stage has a variable integrator capacitance to vary the oscillation frequency. A gain stage is coupled to the integration stage and has a variable gain to vary the oscillation frequency of the integration stage. The sensor interface also has a smart digital controller (SDC) coupled to the analog front end to compute the sensor resistance of the resistive sensor based on the oscillation frequency. In addition, the SDC automatically detects unstable oscillation in the integration stage and causes the variable gain and the variable integrator capacitance to change.

公开(公告)号：US12048668B2

公开(公告)日：2024-07-30

申请号：US17911526

申请日：2021-03-19

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Sergei V. Sarkisian ,  Tommaso Lenzi ,  Dante Amico Bennett Archangeli

IPC: A61H3/00 ,  A61H1/02 ,  B25J9/00

CPC classification number: A61H3/00 ,  A61H1/024 ,  A61H1/0244 ,  B25J9/0006 ,  A61H2003/007 ,  A61H2201/123 ,  A61H2201/1436 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2201/1673

Abstract: An exoskeleton device that includes an artificial joint and a frame member extending from the artificial joint. The frame member is configured for extension over a limb of a user. The exoskeleton device also includes a self-aligning mechanism connected to the frame member. The self-aligning mechanism includes three passive degrees of freedom (pDOF) provided in a prismatic-revolute-revolute (PRR) configuration. The self-aligning mechanism also includes a limb attachment member configured for mechanically coupling to a portion of the limb of the user.

公开(公告)号：USRE50048E1

公开(公告)日：2024-07-23

申请号：US16998339

申请日：2020-08-20

Applicant: University of Utah Research Foundation

Inventor： James Kercher ,  John Helfin

IPC: A61B17/70 ,  A61B17/00

CPC classification number: A61B17/7017 ,  A61B17/7011 ,  A61B17/7014 ,  A61B17/7016

Abstract: Growing rod systems and methods for correcting spinal deformities include at least one growing rod assembly and at least one fluid delivery assembly. Each growing rod assembly includes a fluid actuator that is operable to extend first and second rod segments in opposite directions along the spine. The fluid actuator can be provided by, for example, a piston-cylinder actuator. Each fluid delivery assembly includes a fluid pump operably connectable to a fluid line, which in turn is connected to the fluid actuator. In one embodiment, the fluid actuator is of a linear design. In another embodiment, two linear or curvilinear fluid actuators are provided back-to-back and connected by a connecting rod that mounts to the mid-spine and is contourable. In another embodiment, the fluid actuator is of a curvilinear design to generally conform the normal spine. And in another embodiment, the fluid actuator includes a fluid-over-fluid shock absorber.

公开(公告)号：US12023080B1

公开(公告)日：2024-07-02

申请号：US18375484

申请日：2023-09-30

Applicant: University of Utah Research Foundation

Inventor： Colin S. Gregersen ,  T. Wade Fallin ,  Charles L. Saltzman ,  Chase Hagman

IPC: A61B17/86 ,  A61B17/00 ,  A61B17/56 ,  A61B17/68

CPC classification number: A61B17/866 ,  A61B17/8605 ,  A61B17/863 ,  A61B17/8635 ,  A61B17/864 ,  A61B17/8685 ,  A61B2017/00867 ,  A61B2017/564 ,  A61B2017/681

Abstract: A bone screw may be insertable into a bone. The bone screw may have a distal member with bone-engaging threads, a proximal member configured to slidably engage the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member.

公开(公告)号：US20240210406A1

公开(公告)日：2024-06-27

申请号：US18453745

申请日：2023-08-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen

IPC: G01N33/574 ,  C07K16/24 ,  C12Q1/66 ,  C12Q1/6804 ,  G01N33/542 ,  G01N33/58

CPC classification number: G01N33/57488 ,  C07K16/241 ,  C12Q1/66 ,  G01N33/542 ,  G01N33/581 ,  C07K2317/24 ,  C12Q1/6804 ,  G01N2333/525

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

公开(公告)号：US20240165705A1

公开(公告)日：2024-05-23

申请号：US18518857

申请日：2023-11-24

Applicant: University of Utah Research Foundation

Inventor： Pei Sun ,  Nathan Jump ,  Madapusi Kande Keshavan ,  Zhigang Zak Fang

IPC: B22F10/14 ,  B22F3/10

CPC classification number: B22F10/14 ,  B22F3/1007 ,  B22F3/1021 ,  B22F2201/013 ,  B22F2301/205 ,  B22F2304/10

Abstract: A method of making a densified sintered titanium article includes forming a powder bed of a titanium feedstock. A binder is applied to a portion of the powder bed to bind the titanium feedstock together, thereby forming a green body. The green body is debinded to remove at least a portion of the binder to form a debinded titanium article. The debinded titanium article is sintered at a sintering temperature in an atmosphere comprising hydrogen to produce a sintered titanium article. The sintered titanium article is held at a phase transition temperature to form a microstructure-controlled titanium article. The microstructure-controlled titanium article is dehydrogenated to form a densified sintered titanium article.

公开(公告)号：US11946046B2

公开(公告)日：2024-04-02

申请号：US15734174

申请日：2019-06-14

Applicant: University of Utah Research Foundation

Inventor： Stefan M. Pulst ,  Daniel R. Scoles ,  Sharan Paul

IPC: C12N15/113 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/141 ,  C12N2320/32

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.