公开(公告)号：US20220105048A1

公开(公告)日：2022-04-07

申请号：US17492363

申请日：2021-10-01

Applicant: Applied Materials, Inc.

Inventor： Fei Wang ,  Miaojun Wang ,  Colin C. Neikirk ,  Jonathan Frankel ,  Pravin K. Narwankar

IPC: A61K9/50

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more silicon oxide materials is provided. The method entails alternating exposing the particles to gaseous or vaporous SiCl4 and gaseous or vaporous H2O at a reduced temperature and in the absence of a catalyst.

公开(公告)号：US20220064794A1

公开(公告)日：2022-03-03

申请号：US17522869

申请日：2021-11-09

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Pravin K. Narwankar ,  Kaushal Gangakhedkar ,  Visweswaren Sivaramakrishnan ,  Jonathan Frankel ,  David Masayuki Ishikawa ,  Quoc Truong ,  Joseph Yudovsky

IPC: C23C16/455 ,  C23C16/44 ,  C23C16/442

Abstract: A reactor for coating particles includes one or more motors, a rotary vacuum chamber configured to hold particles to be coated, wherein the rotary vacuum chamber is coupled to the motors, a controller configured to cause the motors to rotate the rotary vacuum chamber about an axial axis of the rotary vacuum chamber such that the particles undergo tumbling agitation, a vacuum port to exhaust gas from the rotary vacuum chamber, a paddle assembly including a rotatable drive shaft extending through the rotary vacuum chamber and coupled to the motors and at least one paddle extending radially from the drive shaft, such that rotation of the drive shaft by the motors orbits the paddle about the drive shaft in a second direction, and a chemical delivery system including a gas outlet on the paddle configured inject process gas into the particles.

公开(公告)号：US20250009671A1

公开(公告)日：2025-01-09

申请号：US18737814

申请日：2024-06-07

Applicant: Applied Materials, Inc.

Inventor： Fei Wang ,  Miaojun Wang ,  Balaji Ganapathy ,  Jonathan Frankel ,  Shivkumar Chiruvolu ,  Pravin K. Narwankar

IPC: A61K9/50 ,  A61K31/397 ,  A61K31/4422 ,  A61K31/517

Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.

公开(公告)号：US20240285542A1

公开(公告)日：2024-08-29

申请号：US18652380

申请日：2024-05-01

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61J3/07 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32 ,  C23C16/40 ,  C23C16/44 ,  C23C16/455 ,  C23C16/458

CPC classification number: A61K9/5089 ,  A61J3/07 ,  A61K9/501 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/2833 ,  C07K16/32 ,  C23C16/40 ,  C23C16/403 ,  C23C16/405 ,  C23C16/4417 ,  C23C16/45525 ,  C23C16/45555 ,  C23C16/458 ,  C07K2317/24 ,  C07K2317/94

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US12071685B2

公开(公告)日：2024-08-27

申请号：US18205273

申请日：2023-06-02

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Quoc Truong ,  Sekar Krishnasamy ,  Govindraj Desai ,  Sandip S. Desai

IPC: C23C16/44 ,  B01F27/051 ,  B01F27/07 ,  B01F27/072 ,  B01F27/112 ,  B01F27/70 ,  B01J19/00 ,  B01J19/18 ,  C23C16/455

CPC classification number: C23C16/4417 ,  B01F27/051 ,  B01F27/0726 ,  B01F27/074 ,  B01F27/112 ,  B01F27/70 ,  B01J19/0066 ,  B01J19/18 ,  C23C16/45555

Abstract: A method of coating particles includes dispensing particles into a vacuum chamber to form a particle bed in at least a lower portion of the chamber that forms a half-cylinder, evacuating the chamber through a vacuum port in an upper portion of the chamber, rotating a paddle assembly such that a plurality of paddles orbit a drive shaft to stir the particles in the particle bed, injecting a reactant or precursor gas through a plurality of channels into the lower portion of the chamber as the paddle assembly rotates to coat the particles, and injecting the reactant or precursor gas or a purge gas through the plurality of channels at a sufficiently high velocity such that the reactant or precursor a purge gas de-agglomerates particles in the particle bed.

公开(公告)号：US20230364023A1

公开(公告)日：2023-11-16

申请号：US18199614

申请日：2023-05-19

Applicant: Applied Materials, Inc.

Inventor： Miaojun Wang ,  Jonathan Frankel ,  Pravin K. Narwankar ,  Suneel Kumar Rastogi ,  Shivkumar Chiruvolu ,  Fei Wang ,  Balaji Ganapathy ,  Shrikant Swaminathan

IPC: A61K9/50

CPC classification number: A61K9/501 ,  A61K9/5089

Abstract: Methods for providing an inorganic oxide coating to high aspect ratio particles containing an active pharmaceutical ingredient are described as are compositions containing such coated particles.

公开(公告)号：US20230313368A1

公开(公告)日：2023-10-05

申请号：US18205273

申请日：2023-06-02

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Quoc Truong ,  Sekar Krishnasamy ,  Govindraj Desai ,  Sandip S. Desai

IPC: C23C16/44 ,  C23C16/455 ,  B01J19/00 ,  B01J19/18 ,  B01F27/051 ,  B01F27/70 ,  B01F27/07 ,  B01F27/112 ,  B01F27/072

CPC classification number: C23C16/4417 ,  C23C16/45555 ,  B01J19/0066 ,  B01J19/18 ,  B01F27/051 ,  B01F27/70 ,  B01F27/074 ,  B01F27/112 ,  B01F27/0726

Abstract: A method of coating particles includes dispensing particles into a vacuum chamber to form a particle bed in at least a lower portion of the chamber that forms a half-cylinder, evacuating the chamber through a vacuum port in an upper portion of the chamber, rotating a paddle assembly such that a plurality of paddles orbit a drive shaft to stir the particles in the particle bed, injecting a reactant or precursor gas through a plurality of channels into the lower portion of the chamber as the paddle assembly rotates to coat the particles, and injecting the reactant or precursor gas or a purge gas through the plurality of channels at a sufficiently high velocity such that the reactant or precursor a purge gas de-agglomerates particles in the particle bed.

公开(公告)号：US20230132290A1

公开(公告)日：2023-04-27

申请号：US17971516

申请日：2022-10-21

Applicant: Applied Materials, Inc.

Inventor： Brian Hayes Burrows ,  Sekar Krishnasamy ,  Ayyanagouda Raravi ,  Monika Mudalkar ,  Govindraj Desai ,  Hemantha Kumar Raju ,  Basavaraj Pattanshetty ,  David Masayuki Ishikawa ,  Visweswaren Sivaramakrishnan ,  Shrikant Swaminathan ,  Mario Cambron ,  Robert Navasca ,  Miaojun Wang ,  Jonathan Frankel

IPC: C23C16/458 ,  C23C16/44 ,  C23C16/455

Abstract: A deposition system includes an isolator or fume hood and a reactor for coating particles, the reactor including a rotatable reactor assembly positioned within the isolator or fume hood and including a reactor drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube. The reactor drum is configured to be detached from the inlet tube and the outlet tube by an operator while the reactor drum remains within the isolator or fume hood.

公开(公告)号：US11384648B2

公开(公告)日：2022-07-12

申请号：US16843358

申请日：2020-04-08

Applicant: Applied Materials, Inc.

Inventor： Yuriy Melnik ,  Sukti Chatterjee ,  Kaushal Gangakhedkar ,  Jonathan Frankel ,  Lance A. Scudder ,  Pravin K. Narwankar ,  David Alexander Britz ,  Thomas Knisley ,  Mark Saly ,  David Thompson

IPC: F01D5/28 ,  F01D9/02 ,  C23C16/455 ,  C23C16/34 ,  C23C16/40 ,  C23C16/30 ,  C23C16/56 ,  F01D25/12 ,  F01D25/28 ,  F23R3/28 ,  C07F11/00 ,  F01D25/14

Abstract: Protective coatings on an aerospace component are provided. An aerospace component includes a surface containing nickel, nickel superalloy, aluminum, chromium, iron, titanium, hafnium, alloys thereof, or any combination thereof, and a coating disposed on the surface, where the coating contains a nanolaminate film stack having two or more pairs of a first deposited layer and a second deposited layer. The first deposited layer contains chromium oxide, chromium nitride, aluminum oxide, aluminum nitride, or any combination thereof, the second deposited layer contains aluminum oxide, aluminum nitride, silicon oxide, silicon nitride, silicon carbide, yttrium oxide, yttrium nitride, yttrium silicon nitride, hafnium oxide, hafnium nitride, hafnium silicide, hafnium silicate, titanium oxide, titanium nitride, titanium silicide, titanium silicate, or any combination thereof, and the first deposited layer and the second deposited layer have different compositions from each other.

公开(公告)号：US20220202732A1

公开(公告)日：2022-06-30

申请号：US17695687

申请日：2022-03-15

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61K47/58 ,  A61K31/506 ,  A61K31/519 ,  A61K31/43 ,  A61K31/405 ,  C07K16/32 ,  C07K16/22 ,  C07K16/28 ,  A61J3/07 ,  C23C16/40 ,  C23C16/455 ,  A61K31/7048 ,  A61K31/424 ,  C23C16/44 ,  C23C16/458

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.