-
公开(公告)号：US09820655B2
公开(公告)日：2017-11-21
申请号：US12680305
申请日：2008-09-29
Applicant: Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
Inventor： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC: A61B5/00
CPC classification number: A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
Abstract: Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
-
22.发明申请公开(公告)号：US20170128132A1
公开(公告)日：2017-05-11
申请号：US15330808
申请日：2016-11-07
Applicant: Bing Yu
Inventor： Bing Yu
Abstract: A fiber optic probe includes a first diffuse reflectance spectroscopy fiber, a second diffuse reflectance spectroscopy fiber, and a temperature sensor at a distal end of a temperature sensor fiber. Other embodiments further include a treatment fiber for delivering a high optical power density of light to a tumor and a dosimetry fiber for monitoring the light flux of the treatment fiber. Other embodiments utilize an image-guidance step in a method of using the fiber optic probe.
-
23.发明授权Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders 有权苯并噻吩衍生物及其组合物作为选择性雌激素受体降解物公开(公告)号：US09561211B2
公开(公告)日：2017-02-07
申请号：US15066425
申请日：2016-03-10
Applicant: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
Inventor： Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
IPC: A61K31/00 , A61K31/381 , C07D333/64 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/4436 , A61K31/506 , A61K45/06 , C07D333/66 , C07D409/12 , C07D413/04 , C07D413/12 , C07D409/04 , C07D409/10 , C07D417/12 , A61K31/397 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/5377
CPC classification number: A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4436 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P35/00 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
Abstract translation: 本发明涉及式I化合物：其中n，m，X，Y 1，R 1，R 2，R 3，R 4和R 5在发明概述中定义; 能够成为雌激素受体的有效拮抗剂和降解物。 本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物来管理与异常雌激素受体活性相关的疾病或病症的方法。
-
24.发明申请Systems and Methods for Performing Optical Spectroscopy Using a Self-Calibrating Fiber Optic Probe 有权使用自校准光纤探头进行光谱分析的系统和方法公开(公告)号：US20110295541A1
公开(公告)日：2011-12-01
申请号：US12989591
申请日：2009-04-27
Applicant: Bing Yu , Nirmala Ramanujam
Inventor： Bing Yu , Nirmala Ramanujam
CPC classification number: G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
Abstract: Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
Abstract translation: 公开了使用自校准光纤探针执行光谱的系统和方法。 一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。 光谱数据包括在一个或多个波长处从样本漫反射的照明光。 自校准光纤探针还可以包括用于传送校准光的校准通道。 校准光和照明光从公共光源同时产生。 校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。
-
公开(公告)号：US5582869A
公开(公告)日：1996-12-10
申请号：US470192
申请日：1995-06-06
Applicant: Bing Yu
Inventor： Bing Yu
CPC classification number: A01N43/80 , Y10T428/31989
Abstract: The invention concerns a method of protecting wood comprising the steps of (a) treating said wood with a composition consisting essentially of (i) 4,5-dichloro-2-n-octyl-3-isothiazolone and optionally one or more other preservative compounds; (ii) a surfactant system consisting of at least one surfactant selected from the group consisting of sulfated anionics, sulfonated anionics, sulfosuccinated anionics, quaternary ammonium cationics, and amphoterics; and (iii) at least one non-polar organic solvent and (b) allowing said solvent to evaporate from said wood.
Abstract translation: 本发明涉及一种保护木材的方法，包括以下步骤：（a）用基本上由（i）4,5-二氯-2-正辛基-3-异噻唑酮和任选的一种或多种其它防腐剂组成的组合物处理所述木材 ; （ii）表面活性剂体系，由选自硫酸化阴离子，磺化阴离子，磺基琥珀酸阴离子，季铵阳离子和两性离子的至少一种表面活性剂体系组成; 和（iii）至少一种非极性有机溶剂和（b）使所述溶剂从所述木材蒸发。
-
Patent Agency Ranking
公开(公告)号：US10524647B2
公开(公告)日：2020-01-07
申请号：US15500626
申请日：2015-07-31
Applicant: Bing Yu , Vivek Krishna Nagarajan
Inventor： Bing Yu , Vivek Krishna Nagarajan
Abstract: A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.
-
公开(公告)号：US20170209033A1
公开(公告)日：2017-07-27
申请号：US15500626
申请日：2015-07-31
Applicant: Bing Yu , Vivek Krishna Nagarajan
Inventor： Bing Yu , Vivek Krishna Nagarajan
Abstract: A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.
-
公开(公告)号：US20160045102A1
公开(公告)日：2016-02-18
申请号：US14824535
申请日：2015-08-12
Applicant: Bing Yu
Inventor： Bing Yu
CPC classification number: A61B1/07 , A61B1/00126 , A61B1/00167 , A61B1/00172 , A61B1/043 , A61B5/0035 , A61B5/0062 , A61B5/0066 , A61B5/0071 , A61B5/0086 , A61B5/0095
Abstract: A multimodal endoscope apparatus includes optical components (couplers, collimators, mirrors, beam splitters, filters and the like) structured to work together to interact with a multimodal endoscope probe to provide at least two imaging modalities selected from fluorescence imaging, optical coherence tomography, and photoacoustic imaging. The multimodal endoscope probe includes a fiber optic imaging bundle including a multitude of optical fibers. In embodiments employing photoacoustic imaging, the multimodal endoscope probe further includes a polymer-Fabry-Perot interferometer. In some embodiments, a galvo scanner and fiber collimator are included and are together capable of directing light to a single optical fiber of the multitude optical fibers. The system is modular in some embodiments, allowing for switching of some components.
Abstract translation: 多模式内窥镜装置包括被构造成一起工作以与多模式内窥镜探针相互作用的光学部件（耦合器，准直器，反射镜，分束器，滤波器等），以提供从荧光成像，光学相干断层摄影和 光声成像。 多模式内窥镜探针包括包括多根光纤的光纤成像束。 在使用光声成像的实施例中，多模式内窥镜探针还包括聚合物法布里 - 珀罗干涉仪。 在一些实施例中，包括电流计扫描器和光纤准直器，并且能够将光引导到多根光纤的单个光纤。 在一些实施例中，系统是模块化的，允许切换一些组件。
-
29.发明授权公开(公告)号：US08804115B2
公开(公告)日：2014-08-12
申请号：US12989591
申请日：2009-04-27
Applicant: Bing Yu , Nirmala Ramanujam
Inventor： Bing Yu , Nirmala Ramanujam
CPC classification number: G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
Abstract: Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
Abstract translation: 公开了使用自校准光纤探针执行光谱的系统和方法。 一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。 光谱数据包括在一个或多个波长处从样本漫反射的照明光。 自校准光纤探针还可以包括用于传送校准光的校准通道。 校准光和照明光从公共光源同时产生。 校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。
-
30.发明申请DIFFUSE REFLECTANCE SPECTROSCOPY DEVICE FOR QUANTIFYING TISSUE ABSORPTION AND SCATTERING 审中-公开用于定量组织吸收和散射的折射率反射光谱装置公开(公告)号：US20110105865A1
公开(公告)日：2011-05-05
申请号：US12989595
申请日：2009-04-24
Applicant: Bing Yu , Nimala Ramanujan , Justin Y. Lo
Inventor： Bing Yu , Nimala Ramanujan , Justin Y. Lo
IPC: A61B5/1455
CPC classification number: A61B5/0059
Abstract: A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted with the tissue mass, wherein the collecting entity comprises a detector comprising one or more photodiodes; measuring turbid spectral data of the tissue mass using the optical probe; converting the turbid spectral data to at least one of absorption and scattering spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying tissue compositions and scatterer size in a tissue mass using the at least one of absorption and scattering spectral data.
Abstract translation: 提供了用于量化组织中的电磁吸收和散射的漫反射光谱系统。 还提供了用于成像组织块的光学探针和方法。 在一些实施例中，所述方法包括使组织块与光学探针接触的步骤，其中所述光学探针包括用于发射与组织块相互作用的光的至少一个实体，然后被传送到收集实体，用于收集光 其与所述组织块相互作用，其中所述收集实体包括检测器，所述检测器包括一个或多个光电二极管; 使用光学探针测量组织块的混浊光谱数据; 通过蒙特卡罗算法或扩散算法将混浊光谱数据转换成吸收和散射光谱数据中的至少一个; 以及使用吸收和散射光谱数据中的至少一个来定量组织块中的组织组成和散射体大小。
-
-
-
-
-
-
-
-
-
Search Results
30
records
(took 0.02 seconds)
