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    Multimodal endoscope apparatus
    1.
    发明授权
    Multimodal endoscope apparatus 有权

    公开(公告)号：US10537235B2

    公开(公告)日：2020-01-21

    申请号：US14824535

    申请日：2015-08-12

    Applicant: Bing Yu

    Inventor： Bing Yu

    IPC: A61B1/07 ,  A61B5/00 ,  A61B1/04

    Abstract: A multimodal endoscope apparatus includes optical components (couplers, collimators, mirrors, beam splitters, filters and the like) structured to work together to interact with a multimodal endoscope probe to provide at least two imaging modalities selected from fluorescence imaging, optical coherence tomography, and photoacoustic imaging. The multimodal endoscope probe includes a fiber optic imaging bundle including a multitude of optical fibers. In embodiments employing photoacoustic imaging, the multimodal endoscope probe further includes a polymer-Fabry-Perot interferometer. In some embodiments, a galvo scanner and fiber collimator are included and are together capable of directing light to a single optical fiber of the multitude optical fibers. The system is modular in some embodiments, allowing for switching of some components.

    Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
    4.
    发明授权
    Smart fiber optic sensors systems and methods for quantitative optical spectroscopy 有权
    智能光纤传感器系统和定量光谱法的方法

    公开(公告)号：US09091637B2

    公开(公告)日：2015-07-28

    申请号：US13513458

    申请日：2010-12-06

    Applicant: Bing Yu ,  Nirmala Ramanujam

    Inventor： Bing Yu ,  Nirmala Ramanujam

    IPC: G01N21/00 ,  G01N21/25 ,  G01N21/27 ,  G01J3/28 ,  G01J3/42 ,  G01J3/02 ,  A61B5/00 ,  G01L9/00 ,  G01N21/64

    CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4331 ,  A61B5/4552 ,  A61B5/6885 ,  A61B2560/0228 ,  G01J3/0218 ,  G01J3/28 ,  G01J3/42 ,  G01L9/0079 ,  G01N21/274 ,  G01N21/645 ,  G01N2201/0627 ,  G01N2201/08

    Abstract: Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.

    Abstract translation: 公开了用于执行定量光谱的智能光纤传感器，系统和方法。 在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。 可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。 接触压力可以调整到一定范围内。 可以从共享光源同时生成校准通道的校准光和感测通道的照明光。 压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

    Smart Fiber-Optic Sensor System and Method for Optical Spectroscopy in Robotic Surgical Systems
    5.
    发明申请
    Smart Fiber-Optic Sensor System and Method for Optical Spectroscopy in Robotic Surgical Systems 审中-公开
    智能光纤传感器系统和机器人手术系统中光学光谱的方法

    公开(公告)号：US20150141768A1

    公开(公告)日：2015-05-21

    申请号：US14523520

    申请日：2014-10-24

    Applicant: Bing Yu ,  Erik D. Engeberg

    Inventor： Bing Yu ,  Erik D. Engeberg

    IPC: A61B1/07 ,  A61B5/107 ,  A61B19/00 ,  A61B1/313 ,  A61B5/00 ,  A61B5/01

    CPC classification number: A61B5/1076 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/015 ,  A61B5/4836 ,  A61B5/6843 ,  A61B5/7203 ,  A61B18/12 ,  A61B34/30 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2018/00791 ,  A61B2090/064 ,  A61B2560/0252

    Abstract: A smart fiber-optic sensor system for use with robotic surgical systems performs optical spectroscopy using a diffuse reflectance spectroscopy (DRS) sensing channel, a self-calibration (SC) channel, a pressure-sensing channel, and a temperature sensing channel. During use of the fiber-optic sensor during a laparoscopic procedure, the pressure-sensing channel ensures that the fiber-optic sensor is maintained in suitable contact with the target tissue being treated. In addition, the temperature sensor is used to ensure that the target tissue does not exceed a desired temperature from the use of an electrosurgical cutting device during the laparoscopic procedure, so as to prevent burning or charring damage at the target tissue.

    Abstract translation: 用于机器人手术系统的智能光纤传感器系统使用漫反射光谱（DRS）感测通道，自校准（SC）通道，压力感测通道和温度感测通道执行光学光谱。 在腹腔镜手术期间使用光纤传感器期间，压力感测通道确保光纤传感器保持与被治疗的靶组织适当的接触。 此外，温度传感器用于确保在腹腔镜手术期间使用电外科切割装置时目标组织不超过所需温度，以防止靶组织上的烧伤或烧伤。

    Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
    8.
    发明授权
    Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation 有权
    通过不对称氢化制备eslicarbazepine和相关化合物

    公开(公告)号：US08367821B2

    公开(公告)日：2013-02-05

    申请号：US12294855

    申请日：2007-04-11

    Applicant: Bing Yu ,  Wenge Li ,  David Alexander Learmonth

    Inventor： Bing Yu ,  Wenge Li ,  David Alexander Learmonth

    IPC: C07D223/22

    CPC classification number: C07D223/22

    Abstract: A process for preparing a compound of the formula IA or IB: wherein R is alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic group with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II: wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.

    Abstract translation: 制备式IA或IB化合物的方法：其中R是烷基，氨基烷基，卤代烷基，芳烷基，环烷基，环烷基烷基，烷氧基，苯基或取代的苯基或吡啶基; 术语烷基是指含有1至18个碳原子的直链或支链的碳链; 术语卤素表示氟，氯，溴或碘; 术语环烷基表示具有3至6个碳原子的饱和脂环基; 术语芳基表示未取代的苯基或被烷氧基，卤素或硝基取代的苯基，该方法包括使用手性催化剂和氢源的式II化合物的不对称氢化：其中R具有与上述相同的含义。

    SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM
    9.
    发明申请
    SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM 有权
    使用仪器，光学探头和蒙特卡罗或扩散算法对组织质量进行光谱分析的系统和方法

    公开(公告)号：US20110112435A1

    公开(公告)日：2011-05-12

    申请号：US12680305

    申请日：2008-09-29

    Applicant: Nirmala Ramanujam ,  Bing Yu ,  Jonathon Quincy Brown

    Inventor： Nirmala Ramanujam ,  Bing Yu ,  Jonathon Quincy Brown

    IPC: A61B10/02

    CPC classification number: A61B5/0091 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/413 ,  A61B5/4312

    Abstract: Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.

    Abstract translation: 提供了使用仪器，光学探针和蒙特卡洛算法或扩散算法对组织块进行光谱分析的系统和方法。 根据一种方法，将器械插入组织块中。 通过仪器将光纤探头施加到组织块中。 使用光纤探针测量组织块的浊度光谱数据。 通过蒙特卡罗算法或扩散算法将浊度光谱数据转换为吸收，散射和/或固有荧光光谱数据。 使用吸收，散射和/或固有的荧光光谱数据来量化组织块中的生物标志物浓度。

    Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
    10.
    发明申请
    Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation 有权
    通过不对称氢化制备eslicarbazepine和相关化合物

    公开(公告)号：US20100173893A1

    公开(公告)日：2010-07-08

    申请号：US12294855

    申请日：2007-04-11

    Applicant: Bing Yu ,  Wenge Li ,  David Alexander Learmont

    Inventor： Bing Yu ,  Wenge Li ,  David Alexander Learmont

    IPC: A61K31/55 ,  C07D223/22 ,  A61P25/24

    CPC classification number: C07D223/22

    Abstract: A process for preparing a compound of the formula IA or IB: wherein R is alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic group with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II: wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.

    Abstract translation: 制备式IA或IB化合物的方法：其中R是烷基，氨基烷基，卤代烷基，芳烷基，环烷基，环烷基烷基，烷氧基，苯基或取代的苯基或吡啶基; 术语烷基是指含有1至18个碳原子的直链或支链的碳链; 术语卤素表示氟，氯，溴或碘; 术语环烷基表示具有3至6个碳原子的饱和脂环基; 术语芳基表示未取代的苯基或被烷氧基，卤素或硝基取代的苯基，该方法包括使用手性催化剂和氢源的式II化合物的不对称氢化：其中R具有与上述相同的含义。

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