公开(公告)号：US20060126062A1

公开(公告)日：2006-06-15

申请号：US11268590

申请日：2005-11-08

Applicant: David Tuschel

Inventor： David Tuschel

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/2889 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

Abstract: The present disclosure describes methods and apparatus to produce a streaming image of a sample during a time period when an attribute of the sample is changing. The streaming image can be viewed in such a manner so as to be able to follow a visible change in an attribute of the sample. The sample may be undergoing nucleation, aggregation, or chemical interaction. The present disclosure also describes methods and apparatus to determine a change in an attribute of a sample by detecting, analyzing, and comparing spectra of the sample taken at different times during the time period when the attribute of the sample is changing. The sample may be undergoing nucleation, aggregation, or chemical interaction.

Abstract translation: 本公开描述了在样本的属性改变的时间段期间产生样本的流图像的方法和装置。 可以以这样的方式来观看流图像，以便能够跟踪样本的属性的可见变化。 样品可能经历成核，聚集或化学相互作用。 本公开还描述了通过检测，分析和比较在样本的属性正在改变的时间段期间在不同时间拍摄的样本的光谱来确定样本的属性变化的方法和装置。 样品可能经历成核，聚集或化学相互作用。

公开(公告)号：US20060124443A1

公开(公告)日：2006-06-15

申请号：US11252414

申请日：2005-10-18

Applicant: David Tuschel ,  Arjun Bangalore

Inventor： David Tuschel ,  Arjun Bangalore

IPC: C07C41/00 ,  C07C45/00

Abstract: The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.

Abstract translation: 本发明涉及通过评估物质颗粒散射的拉曼位移辐射来评估物质的多晶形式的方法。 该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。 本发明还涉及通过在通过相变温度热驱动的情况下照射具有非共振（即，未吸收的）激光辐射的材料来选择和控制多晶型形成的方法。

公开(公告)号：US07046359B2

公开(公告)日：2006-05-16

申请号：US10882082

申请日：2004-06-30

Applicant: Thomas C. Voigt ,  David Tuschel ,  John Maier

Inventor： Thomas C. Voigt ,  David Tuschel ,  John Maier

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

Abstract: A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

公开(公告)号：US08467052B1

公开(公告)日：2013-06-18

申请号：US12614000

申请日：2009-11-06

Applicant: Kuanglin Chao ,  Moon S. Kim ,  Alan M. Lefcourt ,  David Tuschel ,  Oksana Olkhovyk ,  Yongliang Liu

Inventor： Kuanglin Chao ,  Moon S. Kim ,  Alan M. Lefcourt ,  David Tuschel ,  Oksana Olkhovyk ,  Yongliang Liu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N21/94 ,  G01N33/10

Abstract: System and method for determining the presence of a contaminant in a sample using Raman spectroscopic data. The sample may be food or feed and the contaminant may be melamine. The sample is illuminated with substantially monochromatic light to produce Raman scattered photons. The Raman scattered photons are collected to generate Raman spectroscopic data. The Raman spectroscopic data may comprise at least one of a Raman spectrum and a spatially accurate wavelength resolved Raman image. The Raman spectroscopic data is analyzed to determine the presence or absence of a contaminant in a sample. The concentration of the contaminant in the sample can also be determined by using a ratio algorithm.

Abstract translation: 使用拉曼光谱数据确定样品中污染物的存在的系统和方法。 样品可能是食物或饲料，污染物可能是三聚氰胺。 用基本上单色的光照射样品以产生拉曼散射的光子。 收集拉曼散射的光子以产生拉曼光谱数据。 拉曼光谱数据可以包括拉曼光谱和空间上准确的波长分辨拉曼图像中的至少一个。 分析拉曼光谱数据以确定样品中是否存在污染物。 样品中污染物的浓度也可以通过使用比例算法来确定。

公开(公告)号：US07956991B2

公开(公告)日：2011-06-07

申请号：US12211960

申请日：2008-09-17

Applicant: Arjun S. Bangalore ,  David Tuschel

Inventor： Arjun S. Bangalore ,  David Tuschel

IPC: G01N21/00 ,  G01J3/30

CPC classification number: G01N21/31 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/178

Abstract: A method and apparatus of obtaining a spectral image of a plurality of predetermined chemical species. A sample is illuminated to produce photons. These photons are collected to produce a plurality of images for each predetermined chemical species, wherein each image comprises a frame consisting of a plurality of pixels. A wavelength range is identified wherein a chemical species exhibits a unique absorption of radiation. Pixels are identified that do not comprise the chemical species. The steps may be repeated for a plurality of chemical species. If more than one chemical species is present, the contribution of each in a pixel is separated and separate spectral images of each species is composed.

Abstract translation: 一种获得多个预定化学物种的光谱图像的方法和装置。 样品被照亮以产生光子。 收集这些光子以产生用于每个预定化学物种的多个图像，其中每个图像包括由多个像素组成的帧。 鉴定其中化学物质表现出独特的辐射吸收的波长范围。 识别出不包含化学物质的像素。 对于多种化学物质可以重复这些步骤。 如果存在多于一种化学物质，则每个像素的贡献被分离，并且组成每个物种的分离的光谱图像。

公开(公告)号：US20090161101A1

公开(公告)日：2009-06-25

申请号：US12272300

申请日：2008-11-17

Applicant: David Tuschel

Inventor： David Tuschel

IPC: G01J3/44 ,  G01J3/00

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/3577

Abstract: The present disclosure describes methods and apparatus to produce a streaming image of a sample during a time period when an attribute of the sample is changing. The streaming image can be viewed in such a manner so as to be able to follow a visible change in an attribute of the sample. The sample may be undergoing nucleation, aggregation, or chemical interaction. The present disclosure also describes methods and apparatus to determine a change in an attribute of a sample by detecting, analyzing, and comparing spectra of the sample taken at different times during the time period when the attribute of the sample is changing. The sample may be undergoing nucleation, aggregation, or chemical interaction.

Abstract translation: 本公开描述了在样本的属性改变的时间段期间产生样本的流图像的方法和装置。 可以以这样的方式来观看流图像，以便能够跟踪样本的属性的可见变化。 样品可能经历成核，聚集或化学相互作用。 本公开还描述了通过检测，分析和比较在样本的属性正在改变的时间段期间在不同时间拍摄的样本的光谱来确定样本的属性变化的方法和装置。 样品可能经历成核，聚集或化学相互作用。

公开(公告)号：US20090059220A1

公开(公告)日：2009-03-05

申请号：US11918487

申请日：2005-04-08

Applicant: David Tuschel ,  Thomas C. Voigt

Inventor： David Tuschel ,  Thomas C. Voigt

IPC: G01J3/00

CPC classification number: G01J3/42 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/65

Abstract: The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array for receiving said plurality of samples, the array having an external dimension such that the samples are within a simultaneous field of view of the optical device; an optical device for collecting the interacted photons and directing the photons to an imaging device, the imaging device simultaneously forming a plurality of images corresponding to each of the plurality of samples.

Abstract translation: 本公开涉及用于微阵列的化学成像的系统和方法。 在一个实施例中，本公开涉及一种用于同时对阵列上布置的多个样本进行光谱成像的系统。 该系统包括用于向所述多个样本提供照明光子的照明源，所述照明光子与所述多个样本中的每一个相互作用以发射相互作用的光子; 用于接收所述多个样本的阵列，所述阵列具有使得所述样本在所述光学装置的同时视野内的外部尺寸; 用于收集相互作用的光子并将光子引导到成像装置的光学装置，成像装置同时形成对应于多个样本中的每一个的多个图像。

公开(公告)号：US07465911B2

公开(公告)日：2008-12-16

申请号：US11907613

申请日：2007-10-15

Applicant: David Tuschel ,  John S. Maier

Inventor： David Tuschel ,  John S. Maier

IPC: H01L27/00

CPC classification number: G01N21/6428 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423

Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

Abstract translation: 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

公开(公告)号：US20080094614A1

公开(公告)日：2008-04-24

申请号：US11975403

申请日：2007-10-19

Applicant: David Tuschel ,  Arjun Bangalore

Inventor： David Tuschel ,  Arjun Bangalore

IPC: G01N21/00 ,  G21G5/00 ,  G01J1/00 ,  G01J3/28 ,  G01J3/30 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01N21/274 ,  G01N21/65

Abstract: A pulse photobleaching methodology wherein a monochromatic illumination (e.g., laser illumination) having a higher power intensity (photobleaching power) just below the photodamage threshold of a luminescent sample is initially used to significantly attenuate sample luminescence without photothermally destroying the sample material. Thereafter, the laser power density may be reduced to a significantly lower level (analytical power level) to carry out spectroscopic measurements (e.g., collection of Raman scattered photons) on the sample. In one embodiment, the laser illumination wavelength remains the same despite changes in laser power intensity. Some figures-of-merit may be computed from optical measurements made at the analytical power level to guide the photobleaching process. Sample-dependent combinations of laser power density and short exposure times may be obtained to significantly expedite photobleaching to assist in collection of sample spectral data in the field without a long wait. Portable spectroscopy systems employing pulse photobleaching may be devised for expeditious collection of spectral data from luminescent samples in the field.

Abstract translation: 脉冲光漂白方法，其中最初使用具有刚好低于发光样品的光损伤阈值的较高功率强度（光漂白能力）的单色照明（例如，激光照明）来显着衰减样品发光而不光热地破坏样品材料。 此后，激光功率密度可以降低到显着较低的水平（分析能级），以对样品进行光谱测量（例如，拉曼散射光子的收集）。 在一个实施例中，激光照射波长保持相同，尽管激光功率强度的变化。 可以通过在分析功率级别进行的光学测量来计算一些数字值，以指导光漂白过程。 可以获得激光功率密度和短曝光时间的样品依赖组合，以显着加速光漂白，以帮助在现场收集样品光谱数据而不用长时间等待。 可以设计采用脉冲光漂白的便携式光谱系统，以便从现场的发光样品中快速收集光谱数据。

公开(公告)号：US07342214B2

公开(公告)日：2008-03-11

申请号：US11433650

申请日：2006-05-15

Applicant: David Tuschel ,  John S. Maier

Inventor： David Tuschel ,  John S. Maier

IPC: H01L27/00

CPC classification number: G01N21/6428 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423

Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.