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公开(公告)号：US10978288B2
公开(公告)日：2021-04-13
申请号：US16541425
申请日：2019-08-15
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
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公开(公告)号：US20200350149A1
公开(公告)日：2020-11-05
申请号：US16929840
申请日：2020-07-15
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer includes an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber downstream of the first vacuum chamber, and a third vacuum chamber downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer also includes a tandem quadrupole mass analyser, 3D ion trap mass analyser, 2D or linear ion trap mass analyser, Time of Flight mass analyser, quadrupole-Time of Flight mass analyser, or electrostatic mass analyser arranged in the third vacuum chamber.
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公开(公告)号：US20200013607A1
公开(公告)日：2020-01-09
申请号：US16541425
申请日：2019-08-15
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
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公开(公告)号：US10438786B2
公开(公告)日：2019-10-08
申请号：US15465070
申请日：2017-03-21
Applicant: Micromass UK Limited
Inventor： Ian Trivett , Stephen O'Brien , David Gordon
Abstract: An attachment device for releasably attaching a fluid line to a fluid inlet or outlet is disclosed. The device comprises an attachment member for releasably engaging a fluid inlet or outlet, and an elastic member coupled to the attachment member. The attachment device is attachable to a fluid line such that the attachment member is moveable relative to the fluid line and such that movement of the attachment member relative to the fluid line causes elastic deformation of the elastic member.
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公开(公告)号：US09842727B2
公开(公告)日：2017-12-12
申请号：US15022444
申请日：2014-09-17
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny , Howard Read , Kate Whyatt
CPC classification number: H01J49/0009 , H01J49/0031 , H01J49/10
Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.
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Patent Agency Ranking
公开(公告)号：US09625471B2
公开(公告)日：2017-04-18
申请号：US14563108
申请日：2014-12-08
Applicant: Micromass UK Limited
Inventor： Christopher John Hughes , Therese McKenna , David Gordon , Daniel James Kenny
CPC classification number: G01N33/6848 , H01J49/0031 , H01J49/0045 , Y10T436/24
Abstract: A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.
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公开(公告)号：US20160093480A1
公开(公告)日：2016-03-31
申请号：US14892374
申请日：2014-05-29
Applicant: MICROMASS UK LIMITED
Inventor： David Gordon , Daniel James Kenny
CPC classification number: H01J49/0013 , H01J49/0031 , H01J49/062 , H01J49/16 , H01J49/24
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源，具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 第一真空泵布置并适于泵送第一真空室，其中第一真空泵被布置并适于将第一真空室保持在10mbar的压力。 第一RF离子导向器位于第一真空室内。 离子检测器位于第三真空室中。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 质谱仪还包括分流式涡轮分子真空泵，其包括连接到第二真空室的中间或级间端口和连接到第三真空室的高真空（“HV”）端口。 第一真空泵也被布置并适于作为分流式涡轮分子真空泵的背衬真空泵。 第一台真空泵具有最大的泵送速度，nlE; 10 m3 / hr（2.78 L / s）。
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公开(公告)号：US20240201149A1
公开(公告)日：2024-06-20
申请号：US18556758
申请日：2022-04-22
Applicant: Micromass UK Limited
Inventor： Richard Barrington Moulds , David Gordon
CPC classification number: G01N30/7233 , B01D15/08 , H01J49/4215 , G01N2030/027
Abstract: A method of mass analysing a single analytical sample is disclosed comprising: i) transmitting different species of ions through a mass spectrometer; ii) sequentially mass analysing, or otherwise detecting, said different species of ions in a particular sequential order; and then iii) repeating steps i) and ii), wherein the sequential order in which said different species of ions are mass analysed, or otherwise detected, is different when step ii) is repeated. The sensitivity with which the mass spectrometer is able to detect ions varies for a period of time, and step ii) and iii) are performed during that period of time.
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公开(公告)号：US20240136169A1
公开(公告)日：2024-04-25
申请号：US18546528
申请日：2022-02-15
Applicant: Micromass UK Limited
Inventor： Alastair Booth , Ian Trivett , Anthony Hesse , Mark Walford , David Gordon , Haydn Murray , Stephen Aryton
CPC classification number: H01J49/045 , H01J49/0404 , H01J49/167
Abstract: A nebuliser comprises an outlet aperture and a liquid capillary. A method of operating the nebuliser comprises supplying a gas to the outlet aperture, measuring a flow rate of the gas supplied to the outlet aperture, and determining a position of the liquid capillary relative to the outlet aperture based on the measured flow rate.
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公开(公告)号：US20230326733A1
公开(公告)日：2023-10-12
申请号：US18042956
申请日：2021-08-26
Applicant: Micromass UK Limited
Inventor： David Gordon , Nicola Lumley , Alastair Booth , Richard Moulds
CPC classification number: H01J49/06 , H01J49/0036
Abstract: A mass spectrometer is disclosed comprising: an ion detector; ion optics for guiding ions to the ion detector; one or more voltage supply for supplying voltages to said ion optics; control circuitry for controlling the one or more voltage supply so as to switch the ion optics between operating in a first mode in which the ion optics are unable to transmit ions having a first mass to charge ratio or first polarity to the ion detector and a second mode in which the ion optics are able to transmit ions having said first mass to charge ratio or first polarity to the ion detector for a time period; and to repeatedly switch between the first and second modes a plurality of times; and a processor and circuitry configured to: (i) determine the intensity of an ion signal detected by the detector at a first time in each of the time periods that the ion optics are in the second mode; and (ii) determine the intensity of the ion signal detected by the detector at a second, later time in each of the time periods that the ion optics are in the second mode.
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