公开(公告)号：US10236171B2

公开(公告)日：2019-03-19

申请号：US15022396

申请日：2014-09-17

Applicant: Micromass UK Limited

Inventor： Stevan Bajic ,  David Gordon ,  Daniel James Kenny ,  Richard Barrington Moulds ,  Stephen O'Brien ,  Ian Trivett ,  Kate Whyatt

IPC: H01J49/10 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04

Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

公开(公告)号：US20160233070A1

公开(公告)日：2016-08-11

申请号：US15022677

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： David Gordon ,  Joseph Jarrell ,  Daniel James Kenny ,  Stephen O'Brien ,  Ian Trivett

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0422 ,  H01J49/0013 ,  H01J49/04 ,  H01J49/0495 ,  H01J49/066

Abstract: An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process.

Abstract translation: 公开了一种用于连接到质谱仪壳体的离子入口组件，其包括具有采样孔的取样限制体。 采样限制体包括镍盘，其中盘和采样孔由电铸工艺制成或形成。