公开(公告)号：US20240203719A1

公开(公告)日：2024-06-20

申请号：US18285715

申请日：2022-04-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Aaron Timothy BOOY ,  James HAGER

IPC: H01J49/06

CPC classification number: H01J49/066 ,  H01J49/061

Abstract: In one aspect, an ion guide for use in a mass spectrometer is disclosed, which comprises a pair of printed circuit boards (PCBs) having an inlet for receiving a plurality of ions from an upstream ion source and outlet through which the ions exit the ion guide. The ion guide includes at least two ion paths provided in the space between the two PCBs for transmission of ions from the inlet to the outlet. The ion guide can further include at least one ion-routing device that can be coupled to the ions paths for selecting a propagation path of the ions between those ion paths. In some embodiments, the two ion paths can have at least one segment in common.

公开(公告)号：US20240038519A1

公开(公告)日：2024-02-01

申请号：US18345595

申请日：2023-06-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Kenneth R. NEWTON ,  Tong CHEN ,  Stephen ZANON

IPC: H01J49/06

CPC classification number: H01J49/066 ,  H01J49/063

Abstract: In some examples, a multipole section-based ion funnel may include an ion funnel section formed by at least one pair of adjacently disposed members. A first member of the at least one pair of adjacently disposed members may include a pole structure. A second member of the at least one pair of adjacently disposed members may include a pole structure that is engageable with the pole structure of the first member to form a multipole structure.

公开(公告)号：US20180233342A1

公开(公告)日：2018-08-16

申请号：US15747159

申请日：2016-07-28

Applicant: THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： JARED J. BOOCK ,  JOAQUIN JESUS CASANOVA ,  RICHARD A. YOST ,  BRIAN SMITH

IPC: H01J49/06 ,  H01J49/00

CPC classification number: H01J49/066 ,  H01J49/0031

Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.

公开(公告)号：US09741552B2

公开(公告)日：2017-08-22

申请号：US14978508

申请日：2015-12-22

Applicant: Bruker Daltonics, Inc.

Inventor： Melvin Andrew Park ,  Mark Ridgeway ,  Desmond Allen Kaplan ,  Felician Muntean

IPC: H01J49/42 ,  H01J49/10

CPC classification number: H01J49/4225 ,  G01N27/622 ,  H01J49/0045 ,  H01J49/066 ,  H01J49/10

Abstract: The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

公开(公告)号：US09564305B2

公开(公告)日：2017-02-07

申请号：US14445595

申请日：2014-07-29

Applicant: Smiths Detection Inc.

Inventor： Vadym Berkout ,  Jan Hendrikse

IPC: H01J49/06

CPC classification number: H01J49/066

Abstract: A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.

Abstract translation: 描述了样品入口装置和使用样品入口装置的方法，其包括具有多个电极的离子漏斗，所述多个电极具有围绕从离子漏斗的入口延伸到离子漏斗的出口的轴线排列的离子漏斗 包括与所述多个电极同轴设置的多个间隔元件，所述多个间隔元件中的每一个位于一个或两个相邻的电极之间，所述多个间隔元件中的每一个具有直径大于 每个相邻电极。 离子漏斗被配置为使离子样品通过电极和间隔元件的孔通过检测系统的附加部分，例如质量分析器系统和检测器。

公开(公告)号：US09230790B2

公开(公告)日：2016-01-05

申请号：US14369932

申请日：2012-11-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Alexandre V. Loboda

IPC: H01J49/06 ,  H01J49/26

CPC classification number: H01J49/066 ,  H01J49/26

Abstract: Systems and related methods are disclosed herein that generally involve focusing dispersed ions using one or more DC ion funnels. In some embodiments, a DC ion funnel is provided that includes a plurality of ring-shaped electrodes, each having an aperture formed therein such that the funnel defines an interior volume extending between an ion inlet and an ion outlet. A controller applies a DC potential to each of the electrodes without applying an RF potential to any of the electrodes, such that ions entering the funnel are substantially confined within said volume. The interior volume can have any of a variety of shapes, such as cylindrical, frusto-conical, and curved frusto-conical. In addition, any of a variety of DC potentials can be applied to the plurality of electrodes.

Abstract translation: 本文公开的系统和相关方法通常涉及使用一个或多个DC离子漏斗聚焦分散的离子。 在一些实施例中，提供了DC离子漏斗，其包括多个环形电极，每个电极具有形成在其中的孔，使得漏斗限定在离子入口和离子出口之间延伸的内部容积。 控制器将DC电位施加到每个电极，而不对任何电极施加RF电势，使得进入漏斗的离子基本上被限制在所述体积内。 内部容积可以具有各种形状，例如圆柱形，截头圆锥形和弯曲的截头圆锥形。 此外，可以对多个电极施加各种DC电位中的任何一个。

公开(公告)号：US09117645B2

公开(公告)日：2015-08-25

申请号：US13673622

申请日：2012-11-09

Applicant: SRI International

Inventor： Friso H. W. van Amerom ,  Ashish Chaudhary ,  R. Timothy Short

IPC: H01T23/00 ,  H01J49/06

CPC classification number: H01J49/066 ,  H01T23/00

Abstract: A planar ion funnel is disclosed that can be used for ion control. In one application, the planar ion funnel can be used for ion control in a mass spectrometer. The planar ion funnel can be formed on a surface of a substantially planar substrate including an orifice. An electrically conductive structure can be formed on a top surface of the substrate that surrounds the orifice. In operation, a power can be applied to the conductive structure that causes an electric field to be generated that draws ions into and through the orifice. In one embodiment, the orifice can be circular and the conductive structure can be a series of nested rings of increasing diameter surrounding the orifice.

Abstract translation: 公开了可用于离子控制的平面离子漏斗。 在一个应用中，平面离子漏斗可用于质谱仪中的离子控制。 平面离子漏斗可以形成在包括孔口的基本上平面的基板的表面上。 导电结构可以形成在围绕孔口的基板的顶表面上。 在操作中，可以向导电结构施加功率，导致产生电场，其将离子吸入并通过孔。 在一个实施例中，孔可以是圆形的，并且导电结构可以是围绕孔的直径增加的一系列嵌套环。

公开(公告)号：US09053915B2

公开(公告)日：2015-06-09

申请号：US13626698

申请日：2012-09-25

Applicant: Agilent Technologies, Inc.

Inventor： Trygve Ristroph ,  Gershon Perelman

IPC: H01J49/06

CPC classification number: H01J49/065 ,  H01J49/062 ,  H01J49/066 ,  H01J49/067

Abstract: Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system.

Abstract translation: 描述了用于质谱（MS）系统的离子导向器。 离子导向器被配置为提供反射电动力场和直流（DC或静态）电场，以提供在空间上被限制在较大质量范围内的离子束。 在离子源和MS系统的第一级真空室之间提供一些离子导向器。

公开(公告)号：US08859961B2

公开(公告)日：2014-10-14

申请号：US13345392

申请日：2012-01-06

Applicant: Gershon Perelman ,  Trygve Ristroph

Inventor： Gershon Perelman ,  Trygve Ristroph

IPC: H01J49/06

CPC classification number: H01J49/066 ,  H01J3/14 ,  H01J49/062 ,  H01J49/067

Abstract: Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range.

Abstract translation: 描述了用于质谱（MS）系统的离子导向器。 离子导向器被配置为提供反射电动力场和直流（DC或静态）电场，以提供在空间上被限制在较大质量范围内的离子束。

公开(公告)号：US08779353B2

公开(公告)日：2014-07-15

申请号：US13347754

申请日：2012-01-11

Applicant: Stephen Zanon ,  Maurizio A. Splendore

Inventor： Stephen Zanon ,  Maurizio A. Splendore

IPC: H01J3/14 ,  B01D59/44

CPC classification number: H01J49/065 ,  H01J49/066

Abstract: An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.

Abstract translation: 将离子通常以高压水平传输到质量分析器的离子导向器通常在低压水平下具有多个相同的电极，该电极用形成离子通道或离子漏斗的突出元件制成， 电极围绕共同的纵向轴线组装。 突出元件允许产生径向限制离子所需的射频场。 每个电极可以由诸如金属的导电材料的固体块来加工。 所公开的装置大大简化了制造过程，降低了成本，提高了离子导向器本身的鲁棒性和可靠性。