公开(公告)号：US12290689B2

公开(公告)日：2025-05-06

申请号：US17579218

申请日：2022-01-19

Applicant: The George Washington University ,  Northwestern University

Inventor： Igor R. Efimov ,  Jaclyn Ann Brennan ,  John A. Rogers

IPC: A61N1/362 ,  A61B18/14 ,  A61M25/10 ,  A61N1/368 ,  A61B18/00

Abstract: Systems and methods are disclosed for an electrical sensing, pacing, and ablation device comprising a bendable and stretchable balloon catheter and a bendable and stretchable first layer connected to or embedded in said balloon catheter, where the first layer has an electrode array with a plurality of electrodes. The is also a bendable and stretchable second layer connected to or embedded in the balloon catheter, and the second layer has a pressure sensor array with a plurality of pressure sensors.

公开(公告)号：US20240260841A1

公开(公告)日：2024-08-08

申请号：US18397618

申请日：2023-12-27

Applicant: The University of Chicago ,  Northwestern University

Inventor： Esra Tasali ,  Florian Chapotot ,  John A. Rogers

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11 ,  A61B5/1455 ,  A61B5/318 ,  G10L25/66 ,  G16H40/67 ,  H02J50/10 ,  H04R1/08

CPC classification number: A61B5/02055 ,  A61B5/002 ,  A61B5/1118 ,  A61B5/14551 ,  A61B5/318 ,  A61B5/4082 ,  A61B5/4205 ,  A61B5/4803 ,  A61B5/4815 ,  A61B5/6815 ,  A61B5/682 ,  A61B5/6822 ,  A61B5/6823 ,  A61B5/6898 ,  A61B5/7267 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  G10L25/66 ,  G16H40/67 ,  H04R1/08 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/0823 ,  A61B2503/045 ,  A61B2560/0214 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61B2562/0223 ,  A61B2562/0247 ,  A61B2562/164 ,  H02J50/10

Abstract: Conventional multimodal bio-sensing demands multiple rigid sensors mounting on the multiple measuring sites at the designated place and during the reserved time. A soft, and conformal device utilizing MEMS accelerometer is a game changer to this tradition. It is suitable for use in a continuous, wearable mode of operation in recording mechano-acoustic signals originated from human physiological activities. The virtue of device, including the multiplex sensing capability, establishes new opportunity space that continuously records high fidelity signal on epidermis ranges from the subtle vibration of the skin on the order of ˜5×10−3 m·s−2 to the large inertia amplitude of the body ˜20 m·s−2, and from static gravity to audio band of 800 Hz. Minimal spatial and temporal constraints of the device that operates beyond the clinical environment would amplify the benefit of unusual mechanics of the electronics. Therefore, we develop system level, wireless flexible mechano-acoustic device to record multiple physiological information from a single location, suprasternal notch. From this unique location, the 3-axis accelerometer concurrently acquires locomotion, anatomic orientation, swallowing, respiration, cardiac activities, vocal fold vibration, and other mechano-acoustic signal that falls into bandwidth of the sensor capacity that are superposed to a single stream of data. The multiple streamlines of the algorithm parse this high density of information into meaningful physiological information. The recording continues for 48 hours. We also demonstrate the devices' capability in measuring essential vital signals (heart rate, respiration rate, energy intensity) as well as unconventional bio-markers (talking time, swallow counts, etc.) from the healthy normal in numerous field studies. We validate the results against gold standards and demonstrate clinical agreement and application in the clinical sleep studies.

公开(公告)号：US12023489B2

公开(公告)日：2024-07-02

申请号：US17507291

申请日：2021-10-21

Applicant: Washington University ,  Northwestern University

Inventor： Wilson Z. Ray ,  Matthew R. MacEwan ,  Zohny S. Zohny ,  John A. Rogers

IPC: A61N1/20 ,  A61N1/04 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375

CPC classification number: A61N1/205 ,  A61N1/0456 ,  A61N1/0504 ,  A61N1/37217 ,  A61N1/375 ,  A61N1/20

Abstract: A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.

公开(公告)号：US11874965B2

公开(公告)日：2024-01-16

申请号：US17466094

申请日：2021-09-03

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Shuai Xu ,  In Hwa Jung ,  Ha Uk Chung ,  Xinge Yu ,  Yu Yang ,  Jungyup Lee ,  Rujie Sun

IPC: G06F3/01 ,  H04W4/80 ,  G06F1/16 ,  G06T19/00

CPC classification number: G06F3/015 ,  G06F1/163 ,  G06F3/016 ,  G06T19/006 ,  H04W4/80

Abstract: Provided are actuation devices, virtual reality devices formed from the actuation devices, and related virtual reality methods. The devices may comprise a plurality of spatially distributed actuators, each actuator configured for interacting with a biological skin surface; a wireless controller configured to receive operative command signals to control each of the actuators; and a wireless power system to power the actuators. Also provided are unique layouts of multiple interconnected devices to achieve large area coverage.

公开(公告)号：US11786168B2

公开(公告)日：2023-10-17

申请号：US16616898

申请日：2018-06-01

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Johnathan T. Reeder ,  Amay J. Bandodkar ,  Sungbong Kim ,  Yurina Sekine ,  Jungil Choi ,  Tyler R. Ray ,  Aurelie Hourlier-Fargette ,  Philipp Gutruf ,  Kun Hyuck Lee ,  Milan Raj

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/01 ,  A61B5/103

CPC classification number: A61B5/4266 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/1032 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B2562/0242 ,  A61B2562/0276 ,  A61B2562/164

Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

公开(公告)号：US20230277303A1

公开(公告)日：2023-09-07

申请号：US18024327

申请日：2021-09-07

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Anthony R. Banks ,  Di Lu

IPC: A61F2/24 ,  A61B5/0215 ,  A61B5/00

CPC classification number: A61F2/24 ,  A61B5/0215 ,  A61B5/686 ,  A61B5/6869

Abstract: Provided are systems and methods for wireless, LCR-based, passive sensor systems for catheter or other implantable deployment using collapsible electromechanics. Each sensor system includes a deformable coil and a capacitive pressure sensor, collectively forming a LCR circuit having a self-resonant frequency. Multiple sensor systems may be implanted in a collapsible artificial valve to non-invasively detect the status of the collapsible artificial valve. Specifically, when the collapsible artificial valve is implanted in a mammal subject, antennas may be disposed on the skin of the mammal subject to wirelessly measure the self-resonant frequencies of the LCR circuits of the sensor systems. Thus, the blood pressure of the mammal subject may be calculated based on the self-resonant frequencies measured by the antenna, and the status of the collapsible artificial valve may be determined based on the blood pressure.

公开(公告)号：US20220364914A1

公开(公告)日：2022-11-17

申请号：US17623935

申请日：2020-07-02

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Kyeongha Kwon ,  Seung Yun Heo ,  Anthony R. Banks ,  John A. Rogers

IPC: G01J1/42 ,  G01J1/02 ,  G01J1/46

Abstract: A system for measuring a radiant exposure of electromagnetic radiation includes an accumulation detection module having a detector and configured to continuously monitor an electromagnetic radiation received by the detector; and an adaptive circuit configured to periodically interrogate the accumulation detection module; adjust a frequency of interrogation of the accumulation detection module based on an intensity of the electromagnetic radiation received by the detector; and autonomously transmit information related to an amount of the electromagnetic radiation received by the detector to a remote device.

公开(公告)号：US20220125389A1

公开(公告)日：2022-04-28

申请号：US17568771

申请日：2022-01-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US11246522B2

公开(公告)日：2022-02-15

申请号：US16969649

申请日：2019-02-22

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Michel Kliot ,  Roozbeh Ghaffari ,  YuHao Liu

IPC: A61B5/04 ,  A61B5/24 ,  A61B5/296 ,  A61B5/398 ,  A61B5/25 ,  A61B5/00 ,  A61N1/04

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameterps (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

公开(公告)号：US11112869B2

公开(公告)日：2021-09-07

申请号：US16481209

申请日：2018-01-26

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Shuai Xu ,  In Hwa Jung ,  Ha Uk Chung ,  Xinge Yu ,  Yu Yang ,  Jungyup Lee ,  Rujie Sun

IPC: G06F3/01 ,  H04W4/80 ,  G06F1/16 ,  G06T19/00

Abstract: Provided are actuation devices, virtual reality devices formed from the actuation devices, and related virtual reality methods. The devices may comprise a plurality of spatially distributed actuators, each actuator configured for interacting with a biological skin surface; a wireless controller configured to receive operative command signals to control each of the actuators; and a wireless power system to power the actuators. Also provided are unique layouts of multiple interconnected devices to achieve large area coverage.